دورية أكاديمية
أعرض في EDS

Does bilateral Wilms' tumor involving the collecting system in children have a worse prognosis?

التفاصيل البيبلوغرافية
العنوان: Does bilateral Wilms' tumor involving the collecting system in children have a worse prognosis?
المؤلفون: Fang Y; Department of Urology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No. 56 Nanlishi St, Xicheng District, Beijing, 100045, China., Li Z; Department of Urology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No. 56 Nanlishi St, Xicheng District, Beijing, 100045, China. 13810120220@126.com., Song H; Department of Urology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No. 56 Nanlishi St, Xicheng District, Beijing, 100045, China. songhch1975@126.com., Zhang W; Department of Urology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No. 56 Nanlishi St, Xicheng District, Beijing, 100045, China., Li N; Department of Urology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No. 56 Nanlishi St, Xicheng District, Beijing, 100045, China., Yang Y; Department of Urology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No. 56 Nanlishi St, Xicheng District, Beijing, 100045, China.
المصدر: BMC urology [BMC Urol] 2024 Jul 08; Vol. 24 (1), pp. 141. Date of Electronic Publication: 2024 Jul 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968571 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2490 (Electronic) Linking ISSN: 14712490 NLM ISO Abbreviation: BMC Urol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Wilms Tumor*/pathology , Wilms Tumor*/surgery , Kidney Neoplasms*/pathology , Kidney Neoplasms*/surgery, Humans ; Male ; Female ; Prognosis ; Child, Preschool ; Retrospective Studies ; Infant ; Child ; Kidney Tubules, Collecting/pathology ; Neoplasm Invasiveness ; Organ Sparing Treatments/methods
مستخلص: Background: The literature on nephron-sparing surgery (NSS) in children with bilateral Wilms' tumors (BWT) involving the collection system is mostly comprised of case reports. The present study aimed to summarize the clinical characteristics, treatments, and prognosis of children with BWT involving the collecting system admitted to our pediatric surgery center compared with those whose tumors did not involve the collecting system. A secondary aim was to discuss how to preserve more kidney parenchyma and prevent long-term renal failure under the premise of preventing tumor recurrence.
Methods: Patients with BWT admitted to our pediatric surgery center between January 2008 and June 2022 were reviewed. All included patients were grouped according to the relationship between the tumor and collecting system according to the intraoperative findings. Group I included children with tumor infiltrating the collecting system, group II included children with tumor growing into the collecting system, and group III included children whose tumor did not involve the collecting system. The clinical features, treatments and prognosis of the patients were analyzed.
Results: Seventy patients were enrolled, including 20 patients with 25 sides of tumors infiltrating the collecting system in group I,10 patients with 13 sides of tumors growing into the collecting system in group II, and 40 patients in group III. There was no significant difference in patients age and gender between group I and group II. In total, 20 patients in group I and 9 patients in group II had partial response (PR) after neoadjuvant chemotherapy. In group I, 22 of 25 sides of tumors underwent NSS; in group II, 11 of 13 sides of tumors underwent NSS. During an average follow-up of 47 months, in group I, 6/20 patients relapsed and 2/20 patients died; in group II, 3/10 patients relapsed and 1/10 patient died. There was no significant difference in 4-year overall survival (OS) rate among groups I, II and III (86.36% vs. 85.71%vs. 91.40%, P = 0.902).
Conclusions: To preserve renal parenchyma, NSS is feasible for children with BWT involving the collecting system. There was no significant difference in postoperative long-term OS between patients with BWT involving the collecting system and not involving the collecting system.
(© 2024. The Author(s).)
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معلومات مُعتمدة: Z231100004823034 The Science and Technology Planning Program of Beijing Municipal Science & Technology Commission and Administrative Commission of Zhongguancun Science Park
فهرسة مساهمة: Keywords: Bilateral wilms’ tumor; Collecting system; Nephron-sparing surgery
تواريخ الأحداث: Date Created: 20240708 Date Completed: 20240709 Latest Revision: 20240711
رمز التحديث: 20240711
مُعرف محوري في PubMed: PMC11229180
DOI: 10.1186/s12894-024-01525-5
PMID: 38977987
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2490
DOI:10.1186/s12894-024-01525-5