دورية أكاديمية
In vitro and in silico evaluation of bioactivities and chemical composition of the aerial parts of Anchusa officinalis L. methanol extract.
| العنوان: | In vitro and in silico evaluation of bioactivities and chemical composition of the aerial parts of Anchusa officinalis L. methanol extract. |
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| المؤلفون: | Aljowaie RM; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia., Alsayed MF; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia., Alkubaisi NA; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia., Almarfadi OM; Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia., Farrag MA; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia., Abdulmanea AA; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia., Alfuraydi AA; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia., Abalkhail T; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia., Aboul-Soud MAM; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia., Aziz IM; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia. |
| المصدر: | Cell biochemistry and function [Cell Biochem Funct] 2024 Jul; Vol. 42 (5), pp. e4093. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 8305874 Publication Model: Print Cited Medium: Internet ISSN: 1099-0844 (Electronic) Linking ISSN: 02636484 NLM ISO Abbreviation: Cell Biochem Funct Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford, England : Wiley-Blackwell Original Publication: Guildford, Surrey : Butterworth Scientific Ltd., c1983- |
| مواضيع طبية MeSH: | Plant Extracts*/pharmacology , Plant Extracts*/chemistry , Plant Components, Aerial*/chemistry , Antioxidants*/pharmacology , Antioxidants*/chemistry , Antioxidants*/isolation & purification , Methanol*/chemistry, Humans ; Microbial Sensitivity Tests ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/isolation & purification ; Gram-Negative Bacteria/drug effects ; Gram-Positive Bacteria/drug effects ; Antineoplastic Agents, Phytogenic/pharmacology ; Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/isolation & purification ; Anti-Infective Agents/pharmacology ; Anti-Infective Agents/chemistry ; MCF-7 Cells ; Computer Simulation ; Flavonoids/pharmacology ; Flavonoids/chemistry ; Phenols/pharmacology ; Phenols/chemistry ; Apoptosis/drug effects |
| مستخلص: | The main objective of the study is to evaluate the antioxidant, anticancer, and antimicrobial activities of Anchusa officinalis L. in vitro and in silico. The dried aerial parts of A. officinalis L. were extracted with methanol. Total phenolic and flavonoid content was analyzed. Antioxidant and antimicrobial effects were tested against both gram-positive and gram-negative bacteria. Gas chromatography-mass spectrometry analysis revealed the presence of 10 phytochemical compounds, and cyclobutane (26.07%) was identified as the major photochemical compound. The methanol extract exhibited the maximum amount of total phenolic content (118.24 ± 4.42 mg QE/g dry weight of the dry extract) (R 2 = 0.994) and the total flavonoid content was 94 ± 2.34 mg QE/g dry weight of the dry extract (R 2 = 0.999). The IC (© 2024 John Wiley & Sons Ltd.) |
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| معلومات مُعتمدة: | RSPD2024R801 King Saud University, Riyadh, Saudi Arabia |
| فهرسة مساهمة: | Keywords: antimicrobial activity; antioxidant; apoptosis; cytotoxicity; medicinal plants |
| المشرفين على المادة: | 0 (Plant Extracts) 0 (Antioxidants) Y4S76JWI15 (Methanol) 0 (Anti-Bacterial Agents) 0 (Antineoplastic Agents, Phytogenic) 0 (Anti-Infective Agents) 0 (Flavonoids) 0 (Phenols) |
| تواريخ الأحداث: | Date Created: 20240709 Date Completed: 20240709 Latest Revision: 20240709 |
| رمز التحديث: | 20240709 |
| DOI: | 10.1002/cbf.4093 |
| PMID: | 38978319 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1099-0844 |
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| DOI: | 10.1002/cbf.4093 |