دورية أكاديمية
Composite Hydrogel Sealants for Annulus Fibrosus Repair.
| العنوان: | Composite Hydrogel Sealants for Annulus Fibrosus Repair. |
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| المؤلفون: | Li X; Department of Mechanical Engineering, McGill University, 817 Sherbrooke St W, Montreal, Quebec H3A 0C3, Canada., Huo R; Department of Mechanical Engineering, McGill University, 817 Sherbrooke St W, Montreal, Quebec H3A 0C3, Canada., Li L; Department of Surgery, McGill University, 1650 Cedar Avenue, Montreal, Quebec H3G 1A3, Canada., Cherif H; Department of Surgery, McGill University, 1650 Cedar Avenue, Montreal, Quebec H3G 1A3, Canada., Lan X; Department of Mechanical Engineering, McGill University, 817 Sherbrooke St W, Montreal, Quebec H3A 0C3, Canada.; Department of Surgery, McGill University, 1650 Cedar Avenue, Montreal, Quebec H3G 1A3, Canada., Weber MH; Department of Surgery, McGill University, 1650 Cedar Avenue, Montreal, Quebec H3G 1A3, Canada., Haglund L; Department of Surgery, McGill University, 1650 Cedar Avenue, Montreal, Quebec H3G 1A3, Canada.; Shriners Hospital for Children, 1003 Decarie Blvd, Montreal, Montreal, Quebec H4A 0A9, Canada., Li J; Department of Mechanical Engineering, McGill University, 817 Sherbrooke St W, Montreal, Quebec H3A 0C3, Canada.; Department of Surgery, McGill University, 1650 Cedar Avenue, Montreal, Quebec H3G 1A3, Canada.; Department of Biomedical Engineering, McGill University, 3775 Rue University, Montreal, Quebec H3A 2B4, Canada. |
| المصدر: | ACS biomaterials science & engineering [ACS Biomater Sci Eng] 2024 Aug 12; Vol. 10 (8), pp. 5094-5107. Date of Electronic Publication: 2024 Jul 09. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101654670 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-9878 (Electronic) Linking ISSN: 23739878 NLM ISO Abbreviation: ACS Biomater Sci Eng Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : American Chemical Society, [2015]- |
| مواضيع طبية MeSH: | Annulus Fibrosus*/drug effects , Hydrogels*/chemistry , Hydrogels*/pharmacology, Animals ; Cattle ; Humans ; Printing, Three-Dimensional ; Polyurethanes/chemistry ; Polyurethanes/pharmacology ; Tissue Adhesives/pharmacology ; Tissue Adhesives/chemistry |
| مستخلص: | Intervertebral disc (IVD) herniation is a leading cause of disability and lower back pain, causing enormous socioeconomic burdens. The standard of care for disc herniation is nucleotomy, which alleviates pain but does not repair the annulus fibrosus (AF) defect nor recover the biomechanical function of the disc. Existing bioadhesives for AF repair are limited by insufficient adhesion and significant mechanical and geometrical mismatch with the AF tissue, resulting in the recurrence of protrusion or detachment of bioadhesives. Here, we report a composite hydrogel sealant constructed from a composite of a three-dimensional (3D)-printed thermoplastic polyurethane (TPU) mesh and tough hydrogel. We tailored the fiber angle and volume fraction of the TPU mesh design to match the angle-ply structure and mechanical properties of native AF. Also, we proposed and tested three types of geometrical design of the composite hydrogel sealant to match the defect shape and size. Our results show that the sealant could mimic native AF in terms of the elastic modulus, flexural modulus, and fracture toughness and form strong adhesion with the human AF tissue. The bovine IVD tests show the effectiveness of the composite hydrogel sealant for AF repair and biomechanics recovery and for preventing herniation with its heightened stiffness and superior adhesion. By harnessing the combined capabilities of 3D printing and bioadhesives, these composite hydrogel sealants demonstrate promising potential for diverse applications in tissue repair and regeneration. |
| فهرسة مساهمة: | Keywords: annulus fibrosus; bioadhesive; biomechanical testing; hydrogel; tissue repair |
| المشرفين على المادة: | 0 (Hydrogels) 0 (Polyurethanes) 0 (Tissue Adhesives) |
| تواريخ الأحداث: | Date Created: 20240709 Date Completed: 20240812 Latest Revision: 20240812 |
| رمز التحديث: | 20240813 |
| DOI: | 10.1021/acsbiomaterials.4c00548 |
| PMID: | 38979636 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 2373-9878 |
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| DOI: | 10.1021/acsbiomaterials.4c00548 |