دورية أكاديمية
أعرض في EDS

Two decades of molecular surveillance in Senegal reveal rapid changes in known drug resistance mutations over time.

التفاصيل البيبلوغرافية
العنوان: Two decades of molecular surveillance in Senegal reveal rapid changes in known drug resistance mutations over time.
المؤلفون: Ndiaye YD; International Research Training Center On Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, 16477, Dakar, Senegal., Wong W; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, 665 Huntington Ave, Boston, MA, 02115, USA., Thwing J; Malaria Branch, Division of Parasitic Diseases and Malaria, Global Health Center, Centers for Disease Control and Prevention, Atlanta, GA, USA., Schaffner SF; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA., Brenneman KV; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, 665 Huntington Ave, Boston, MA, 02115, USA., Tine A; International Research Training Center On Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, 16477, Dakar, Senegal., Diallo MA; International Research Training Center On Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, 16477, Dakar, Senegal., Deme AB; International Research Training Center On Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, 16477, Dakar, Senegal., Sy M; International Research Training Center On Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, 16477, Dakar, Senegal., Bei AK; Yale School of Public Health, 60 College St, New Haven, CT, 06510, USA., Thiaw AB; Department of Biochemistry and Functional Genomics, Sherbrooke University, 2500 Bd de L'Universite, Sherbrooke, QC, J1K 2R1, Canada., Daniels R; RNA Therapeutics Institute, UMass Chan Medical School, 368 Plantation Street, Worcester, MA, 01605, USA., Ndiaye T; International Research Training Center On Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, 16477, Dakar, Senegal., Gaye A; International Research Training Center On Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, 16477, Dakar, Senegal., Ndiaye IM; International Research Training Center On Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, 16477, Dakar, Senegal., Toure M; International Research Training Center On Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, 16477, Dakar, Senegal., Gadiaga N; International Research Training Center On Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, 16477, Dakar, Senegal., Sene A; International Research Training Center On Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, 16477, Dakar, Senegal., Sow D; International Research Training Center On Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, 16477, Dakar, Senegal., Garba MN; International Research Training Center On Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, 16477, Dakar, Senegal., Yade MS; International Research Training Center On Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, 16477, Dakar, Senegal., Dieye B; International Research Training Center On Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, 16477, Dakar, Senegal., Diongue K; International Research Training Center On Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, 16477, Dakar, Senegal., Zoumarou D; International Research Training Center On Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, 16477, Dakar, Senegal., Ndiaye A; International Research Training Center On Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, 16477, Dakar, Senegal., Gomis JF; International Research Training Center On Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, 16477, Dakar, Senegal., Fall FB; National Malaria Control Programme (NMCP), 25270, Dakar, Senegal., Ndiop M; National Malaria Control Programme (NMCP), 25270, Dakar, Senegal., Diallo I; National Malaria Control Programme (NMCP), 25270, Dakar, Senegal., Sene D; National Malaria Control Programme (NMCP), 25270, Dakar, Senegal., Macinnis B; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA., Seck MC; International Research Training Center On Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, 16477, Dakar, Senegal., Ndiaye M; International Research Training Center On Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, 16477, Dakar, Senegal., Ngom B; International Research Training Center On Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, 16477, Dakar, Senegal., Diedhiou Y; International Research Training Center On Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, 16477, Dakar, Senegal., Mbaye AM; International Research Training Center On Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, 16477, Dakar, Senegal., Ndiaye L; International Research Training Center On Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, 16477, Dakar, Senegal., Sy N; Service de Lutte Antiparasitaire (SLAP), Thiès, Senegal., Badiane AS; International Research Training Center On Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, 16477, Dakar, Senegal., Hartl DL; Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA, 02138, USA., Wirth DF; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, 665 Huntington Ave, Boston, MA, 02115, USA.; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA., Volkman SK; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, 665 Huntington Ave, Boston, MA, 02115, USA. svolkman@hsph.harvard.edu.; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA. svolkman@hsph.harvard.edu.; Simmons University, 300 The Fenway, Boston, MA, 02115, USA. svolkman@hsph.harvard.edu., Ndiaye D; International Research Training Center On Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, 16477, Dakar, Senegal.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, 665 Huntington Ave, Boston, MA, 02115, USA.
المصدر: Malaria journal [Malar J] 2024 Jul 09; Vol. 23 (1), pp. 205. Date of Electronic Publication: 2024 Jul 09.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101139802 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2875 (Electronic) Linking ISSN: 14752875 NLM ISO Abbreviation: Malar J Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2002-
مواضيع طبية MeSH: Plasmodium falciparum*/drug effects , Plasmodium falciparum*/genetics , Drug Resistance*/genetics , Antimalarials*/pharmacology , Antimalarials*/therapeutic use , Mutation*, Senegal ; Retrospective Studies ; Humans ; Malaria, Falciparum/parasitology ; Malaria, Falciparum/epidemiology ; Polymorphism, Single Nucleotide ; Protozoan Proteins/genetics ; Haplotypes ; Membrane Transport Proteins/genetics
مستخلص: Background: Drug resistance in Plasmodium falciparum is a major threat to malaria control efforts. Pathogen genomic surveillance could be invaluable for monitoring current and emerging parasite drug resistance.
Methods: Data from two decades (2000-2020) of continuous molecular surveillance of P. falciparum parasites from Senegal were retrospectively examined to assess historical changes in malaria drug resistance mutations. Several known drug resistance markers and their surrounding haplotypes were profiled using a combination of single nucleotide polymorphism (SNP) molecular surveillance and whole genome sequence based population genomics.
Results: This dataset was used to track temporal changes in drug resistance markers whose timing correspond to historically significant events such as the withdrawal of chloroquine (CQ) and the introduction of sulfadoxine-pyrimethamine (SP) in 2003. Changes in the mutation frequency at Pfcrt K76T and Pfdhps A437G coinciding with the 2014 introduction of seasonal malaria chemoprevention (SMC) in Senegal were observed. In 2014, the frequency of Pfcrt K76T increased while the frequency of Pfdhps A437G declined. Haplotype-based analyses of Pfcrt K76T showed that this rapid increase was due to a recent selective sweep that started after 2014.
Discussion (conclusion): The rapid increase in Pfcrt K76T is troubling and could be a sign of emerging amodiaquine (AQ) resistance in Senegal. Emerging AQ resistance may threaten the future clinical efficacy of artesunate-amodiaquine (ASAQ) and AQ-dependent SMC chemoprevention. These results highlight the potential of molecular surveillance for detecting rapid changes in parasite populations and stress the need to monitor the effectiveness of AQ as a partner drug for artemisinin-based combination therapy (ACT) and for chemoprevention.
(© 2024. The Author(s).)
التعليقات: Update of: medRxiv. 2023 Apr 26:2023.04.24.23288820. doi: 10.1101/2023.04.24.23288820. (PMID: 37163114)
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معلومات مُعتمدة: INV-004036 United States GATES Bill & Melinda Gates Foundation; U19 AI089696 United States AI NIAID NIH HHS; Investment ID 0PP1200177 and Investment ID INV-004036 Bill and Melinda Gates Foundation; U19AI089696 NIH/ICEMR
المشرفين على المادة: 0 (Antimalarials)
0 (Protozoan Proteins)
0 (Membrane Transport Proteins)
تواريخ الأحداث: Date Created: 20240709 Date Completed: 20240710 Latest Revision: 20240722
رمز التحديث: 20240722
مُعرف محوري في PubMed: PMC11234717
DOI: 10.1186/s12936-024-05024-8
PMID: 38982475
قاعدة البيانات: MEDLINE
الوصف
تدمد:1475-2875
DOI:10.1186/s12936-024-05024-8