دورية أكاديمية
أعرض في EDS

Cross-species transmission and histopathological variation in specific-pathogen-free minipigs infected with different hepatitis E virus strains.

التفاصيل البيبلوغرافية
العنوان: Cross-species transmission and histopathological variation in specific-pathogen-free minipigs infected with different hepatitis E virus strains.
المؤلفون: Jung S; Department of Food and Nutrition, College of Biotechnology and Natural Resources, Chung-Ang University, Anseong, Gyeonggi-Do, 17546, Republic of Korea.; Developmental and Reproductive Toxicology Research Group, Korea Institute of Toxicology, Deajeon, 34114, Republic of Korea., Yeo D; Department of Food and Nutrition, College of Biotechnology and Natural Resources, Chung-Ang University, Anseong, Gyeonggi-Do, 17546, Republic of Korea., Seo DJ; Department of Food and Nutrition, Gwangju University, Gwangju, 61743, Republic of Korea., Choi IS; Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, 120 Neungdong-ro, Seoul, Gwangjin-gu, 05029, Republic of Korea., Choi C; Department of Food and Nutrition, College of Biotechnology and Natural Resources, Chung-Ang University, Anseong, Gyeonggi-Do, 17546, Republic of Korea. cchoi@cau.ac.kr.
المصدر: Veterinary research [Vet Res] 2024 Jul 09; Vol. 55 (1), pp. 87. Date of Electronic Publication: 2024 Jul 09.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 9309551 Publication Model: Electronic Cited Medium: Internet ISSN: 1297-9716 (Electronic) Linking ISSN: 09284249 NLM ISO Abbreviation: Vet Res Subsets: MEDLINE
أسماء مطبوعة: Publication: 2011- : London : BioMed Central
Original Publication: Paris : Editions Scientifiques Elsevier ; INRA, c1993-
مواضيع طبية MeSH: Hepatitis E*/veterinary , Hepatitis E*/virology , Hepatitis E*/transmission , Hepatitis E virus*/physiology , Swine Diseases*/virology , Swine Diseases*/transmission , Swine Diseases*/pathology , Swine, Miniature*, Animals ; Swine ; Specific Pathogen-Free Organisms ; Rabbits ; Virus Shedding ; Humans ; Feces/virology ; Female ; Viremia/veterinary ; Viremia/virology
مستخلص: Hepatitis E virus (HEV) is a major cause of viral hepatitis worldwide. Pigs are the natural host of HEV genotype 3 and the main reservoir of HEV. As the host range of HEV genotype 3 expands, the possibility that HEV from various species can be transmitted to humans via pigs is increasing. We investigated the potential cross-species transmission of HEV by infecting minipigs with swine HEV (swHEV), rabbit HEV (rbHEV), and human HEV (huHEV) and examining their histopathological characteristics and distribution in various organs. Fifteen specific-pathogen-free Yucatan minipigs were infected with swHEV, rbHEV, huHEV, or a mock control. In the present study, we analysed faecal shedding, viremia, and serological parameters over a seven-week period. Our results indicated that swHEV exhibited more robust shedding and viremia than non-swHEVs. Only swHEV affected the serological parameters, suggesting strain-specific differences. Histopathological examination revealed distinct patterns in the liver, pancreas, intestine, and lymphoid tissues after infection with each HEV strain. Notably, all three HEVs induced histopathological changes in the pancreas, supporting the association of HEVs with acute pancreatitis. Our results also identified skeletal muscle as a site of HEV antigen presence, suggesting a potential link to myositis. In conclusion, this study provides valuable insights into the infection dynamics of different HEV strains in minipigs, emphasizing the strain-specific variations in virological, serological, and histological parameters. The observed differences in infection kinetics and tissue tropism will contribute to our understanding of HEV pathogenesis and the potential for cross-species transmission.
(© 2024. The Author(s).)
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معلومات مُعتمدة: NRF2018R1A6A1A03025159 National Research Foundation of Korea
فهرسة مساهمة: Keywords: Hepatitis E virus; cross-species transmission; extrahepatic manifestations; histopathology
تواريخ الأحداث: Date Created: 20240709 Date Completed: 20240710 Latest Revision: 20240712
رمز التحديث: 20240712
مُعرف محوري في PubMed: PMC11234777
DOI: 10.1186/s13567-024-01337-3
PMID: 38982477
قاعدة البيانات: MEDLINE
الوصف
تدمد:1297-9716
DOI:10.1186/s13567-024-01337-3