دورية أكاديمية

Impact of linkage level on inferences from big data analyses in health and medical research: an empirical study.

التفاصيل البيبلوغرافية
العنوان: Impact of linkage level on inferences from big data analyses in health and medical research: an empirical study.
المؤلفون: Lee B; Institute of Health & Environment, Seoul National University, Seoul, Republic of Korea., Lee YK; Department of Orthopedic Surgery, Seoul National University College of Medicine and Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea., Kim SH; Department of Urology, Urologic Cancer Center, Research Institute and Hospital of National Cancer Center, Goyang-si, Republic of Korea., Oh H; Division of Gastroenterology, Department of Internal Medicine, Center for Cancer Prevention and Detection of National Cancer Center, Goyang-si, Republic of Korea., Won S; Institute of Health & Environment, Seoul National University, Seoul, Republic of Korea.; Department of Public Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea.; Interdisciplinary Program for Bioinformatics, College of Natural Science, Seoul National University, Seoul, Republic of Korea., Jang SY; Department of Healthcare Management, Graduate School of Public Health, Yonsei University, Seoul, Republic of Korea., Jeon YJ; Department of Public Health, Graduate School, Yonsei University, Seoul, Republic of Korea., Yoo BN; National Evidence-based Healthcare Collaborating Agency (NECA), 3-5F 400, Neungdong-ro, Gwangin-gu, Seoul, 04933, Republic of Korea., Bak JK; National Evidence-based Healthcare Collaborating Agency (NECA), 3-5F 400, Neungdong-ro, Gwangin-gu, Seoul, 04933, Republic of Korea. xendo2014@gmail.com.
المصدر: BMC medical informatics and decision making [BMC Med Inform Decis Mak] 2024 Jul 09; Vol. 24 (1), pp. 193. Date of Electronic Publication: 2024 Jul 09.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101088682 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-6947 (Electronic) Linking ISSN: 14726947 NLM ISO Abbreviation: BMC Med Inform Decis Mak Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Big Data* , Medical Record Linkage*, Humans ; Female ; Biomedical Research ; Male ; Empirical Research
مستخلص: Background: Linkage errors that occur according to linkage levels can adversely affect the accuracy and reliability of analysis results. This study aimed to identify the differences in results according to personally identifiable information linkage level, sample size, and analysis methods through empirical analysis.
Methods: The difference between the results of linkage in directly identifiable information (DII) and indirectly identifiable information (III) linkage levels was set as III linkage based on name, date of birth, and sex and DII linkage based on resident registration number. The datasets linked at each level were named as database III (DB III ) and database DII (DB DII ), respectively. Considering the analysis results of the DII-linked dataset as the gold standard, descriptive statistics, group comparison, incidence estimation, treatment effect, and moderation effect analysis results were assessed.
Results: The linkage rates for DB DII and DB III were 71.1% and 99.7%, respectively. Regarding descriptive statistics and group comparison analysis, the difference in effect in most cases was "none" to "very little." With respect to cervical cancer that had a relatively small sample size, analysis of DB III resulted in an underestimation of the incidence in the control group and an overestimation of the incidence in the treatment group (hazard ratio [HR] = 2.62 [95% confidence interval (CI): 1.63-4.23] in DB III vs. 1.80 [95% CI: 1.18-2.73] in DB DII ). Regarding prostate cancer, there was a conflicting tendency with the treatment effect being over or underestimated according to the surveillance, epidemiology, and end results summary staging (HR = 2.27 [95% CI: 1.91-2.70] in DB III vs. 1.92 [95% CI: 1.70-2.17] in DB DII for the localized stage; HR = 1.80 [95% CI: 1.37-2.36] in DB III vs. 2.05 [95% CI: 1.67-2.52] in DB DII for the regional stage).
Conclusions: To prevent distortion of the analyses results in health and medical research, it is important to check that the patient population and sample size by each factor of interest (FOI) are sufficient when different data are linked using DB DII . In cases involving a rare disease or with a small sample size for FOI, there is a high likelihood that a DII linkage is unavoidable.
(© 2024. The Author(s).)
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معلومات مُعتمدة: NECA-S-21-004 National Evidence-based Healthcare Collaborating Agency, with funding from the Ministry of Health and Welfare
فهرسة مساهمة: Keywords: Accuracy; Directly identifiable information; Indirectly identifiable information; Linkage levels
تواريخ الأحداث: Date Created: 20240709 Date Completed: 20240710 Latest Revision: 20240712
رمز التحديث: 20240712
مُعرف محوري في PubMed: PMC11234607
DOI: 10.1186/s12911-024-02586-0
PMID: 38982481
قاعدة البيانات: MEDLINE
الوصف
تدمد:1472-6947
DOI:10.1186/s12911-024-02586-0