دورية أكاديمية
Mechanical dyssynchrony as a selection criterion for cardiac resynchronization therapy: Design of the AMEND-CRT trial.
العنوان: | Mechanical dyssynchrony as a selection criterion for cardiac resynchronization therapy: Design of the AMEND-CRT trial. |
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المؤلفون: | Puvrez A; Department of Cardiovascular Diseases, University Hospitals Leuven, Leuven, Belgium.; Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium., Duchenne J; Department of Cardiovascular Diseases, University Hospitals Leuven, Leuven, Belgium.; Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium., Donal E; LTSI, Inserm 1099, LTSI, University of Rennes, Rennes, France.; Department of Cardiology, CHU Rennes, Rennes, France., Gorcsan J 3rd; Heart and Vascular Institute, Penn State University College of Medicine, Hershey, Pennsylvania, USA., Patel HC; Department of Cardiology, Alfred Hospital, Melbourne, Victoria, Australia.; Central Clinical School, Monash University, Melbourne, Victoria, Australia.; Baker Heart and Diabetes Institute, Melbourne, Australia., Marwick TH; Baker Heart and Diabetes Institute, Melbourne, Australia., Smiseth OA; Institute for Surgical Research, Oslo University Hospital and University of Oslo, Oslo, Norway., Søgaard P; Department of Cardiology, Aalborg University Hospital and University of Aalborg, Aalborg, Denmark.; Department of Cardiology, Rigshospitalet, Copenhagen, Denmark., Stankovic I; Faculty of Medicine, University of Belgrade, Belgrade, Serbia.; Department of Cardiology, Clinical Hospital Centre Zemun, Belgrade, Serbia., Diogo PG; Department of Cardiovascular Diseases, University Hospitals Leuven, Leuven, Belgium.; Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium., Vörös G; Department of Cardiovascular Diseases, University Hospitals Leuven, Leuven, Belgium.; Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium., Voigt JU; Department of Cardiovascular Diseases, University Hospitals Leuven, Leuven, Belgium.; Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium. |
المصدر: | ESC heart failure [ESC Heart Fail] 2024 Jul 10. Date of Electronic Publication: 2024 Jul 10. |
Publication Model: | Ahead of Print |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: John Wiley & Sons Ltd on behalf of the European Society of Cardiology Country of Publication: England NLM ID: 101669191 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2055-5822 (Electronic) Linking ISSN: 20555822 NLM ISO Abbreviation: ESC Heart Fail Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [Oxford] : John Wiley & Sons Ltd on behalf of the European Society of Cardiology, [2014]- |
مستخلص: | Aims: One third of patients do not improve after cardiac resynchronization therapy (CRT). Septal flash (SF) and apical rocking (ApRock) are deformation patterns observed on echocardiography in most patients eligible for CRT. These markers of mechanical dyssynchrony have been associated to improved outcome after CRT in observational studies and may be useful to better select patients. The aim of this trial is to investigate whether the current guideline criteria for selecting patients for CRT should be modified and include SF and ApRock to improve therapy success rate, reduce excessive costs and prevent exposure to device-related complications in patients who would not benefit from CRT. Methods: The AMEND-CRT trial is a multicentre, randomized, parallel-group, double-blind, sham-controlled trial with a non-inferiority design. The trial will include 578 patients scheduled for CRT according to the 2021 ESC guidelines who satisfy all inclusion criteria. The randomization is performed 1:1 to an active control arm ('guideline arm') or an experimental arm ('echo arm'). All participants receive a device, but in the echo arm, CRT is activated only when SF or ApRock or both are present. The outcome of both arms will be compared after 1 year. The primary outcome measures are the average change in left ventricular end-systolic volume and patient outcome assessed using a modified Packer Clinical Composite Score. Conclusions: The findings of this trial will redefine the role of echocardiography in CRT and potentially determine which patients with heart failure and a prolonged QRS duration should receive CRT, especially in patients who currently have a class IIa or class IIb recommendation. (© 2024 The Author(s). ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.) |
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معلومات مُعتمدة: | T002919N Research Foundation - Flanders (FWO), Belgium; MRF2006393 Medical Research Future Fund (MRFF) International Clinical Trial Collaborations Program-20.1, Australia |
فهرسة مساهمة: | Keywords: Apical rocking; Cardiac resynchronization therapy; Echocardiography; Guidelines; Methods; Septal flash |
تواريخ الأحداث: | Date Created: 20240710 Latest Revision: 20240710 |
رمز التحديث: | 20240710 |
DOI: | 10.1002/ehf2.14932 |
PMID: | 38984947 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2055-5822 |
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DOI: | 10.1002/ehf2.14932 |