دورية أكاديمية
أعرض في EDS

Adipokinetic hormone signaling mediates the enhanced fecundity of Diaphorina citri infected by ' Candidatus Liberibacter asiaticus'.

التفاصيل البيبلوغرافية
العنوان: Adipokinetic hormone signaling mediates the enhanced fecundity of Diaphorina citri infected by ' Candidatus Liberibacter asiaticus'.
المؤلفون: Li J; National Key Laboratory of Green Pesticide, Department of Entomology, College of Plant Protection, South China Agricultural University, Guangzhou, China., Holford P; School of Science, Western Sydney University, Penrith, Australia., Beattie GAC; School of Science, Western Sydney University, Penrith, Australia., Wu S; National Key Laboratory of Green Pesticide, Department of Entomology, College of Plant Protection, South China Agricultural University, Guangzhou, China., He J; National Key Laboratory of Green Pesticide, Department of Entomology, College of Plant Protection, South China Agricultural University, Guangzhou, China., Tan S; National Key Laboratory of Green Pesticide, Department of Entomology, College of Plant Protection, South China Agricultural University, Guangzhou, China., Wang D; National Key Laboratory of Green Pesticide, Department of Entomology, College of Plant Protection, South China Agricultural University, Guangzhou, China., He Y; National Key Laboratory of Green Pesticide, Department of Entomology, College of Plant Protection, South China Agricultural University, Guangzhou, China., Cen Y; National Key Laboratory of Green Pesticide, Department of Entomology, College of Plant Protection, South China Agricultural University, Guangzhou, China., Nian X; National Key Laboratory of Green Pesticide, Department of Entomology, College of Plant Protection, South China Agricultural University, Guangzhou, China.; Henry Fok School of Biology and Agriculture, Shaoguan University, Shaoguan, China.
المصدر: ELife [Elife] 2024 Jul 10; Vol. 13. Date of Electronic Publication: 2024 Jul 10.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: Fertility* , Signal Transduction* , Insect Hormones*/metabolism , Insect Hormones*/genetics , Hemiptera*/microbiology , Pyrrolidonecarboxylic Acid*/analogs & derivatives , Pyrrolidonecarboxylic Acid*/metabolism, Animals ; Female ; Rhizobiaceae/physiology ; Rhizobiaceae/metabolism ; Lipid Metabolism ; Ovary/microbiology ; Ovary/metabolism ; MicroRNAs/metabolism ; MicroRNAs/genetics ; Juvenile Hormones/metabolism ; Insect Proteins/metabolism ; Insect Proteins/genetics ; Liberibacter ; Oligopeptides
مستخلص: Diaphorina citri serves as the primary vector for ' Candidatus Liberibacter asiaticus ( C Las),' the bacterium associated with the severe Asian form of huanglongbing. C Las-positive D. citri are more fecund than their C Las-negative counterparts and require extra energy expenditure. Therefore, understanding the molecular mechanisms linking metabolism and reproduction is of particular importance. In this study, we found adipokinetic hormone ( DcAKH ) and its receptor ( DcAKHR ) were essential for increasing lipid metabolism and fecundity in response to C Las infection in D. citri . Knockdown of DcAKH and DcAKHR not only resulted in the accumulation of triacylglycerol and a decline of glycogen, but also significantly decreased fecundity and C Las titer in ovaries. Combined in vivo and in vitro experiments showed that miR-34 suppresses DcAKHR expression by binding to its 3' untranslated region, whilst overexpression of miR-34 resulted in a decline of DcAKHR expression and C Las titer in ovaries and caused defects that mimicked DcAKHR knockdown phenotypes. Additionally, knockdown of DcAKH and DcAKHR significantly reduced juvenile hormone (JH) titer and JH signaling pathway genes in fat bodies and ovaries, including the JH receptor, methoprene-tolerant ( DcMet ), and the transcription factor, Krüppel homolog 1 (DcKr-h1 ), that acts downstream of it, as well as the egg development related genes vitellogenin 1-like ( DcVg-1-like ), vitellogenin A1-like ( DcVg-A1-like ) and the vitellogenin receptor ( DcVgR ). As a result, C Las hijacks AKH/AKHR-miR-34-JH signaling to improve D. citri lipid metabolism and fecundity, while simultaneously increasing the replication of C Las, suggesting a mutualistic interaction between C Las and D. citri ovaries.
Competing Interests: JL, PH, GB, SW, JH, ST, DW, YH, YC, XN No competing interests declared
(© 2024, Li et al.)
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معلومات مُعتمدة: 32102193 National Natural Science Foundation of China; 2022SDZG07 The Open Competition Program of Ten Major Directions of Agricultural Science and Technology Innovation for the 14th Five-year Plan of Guangdong Province
فهرسة مساهمة: Keywords: ecology; insect reproduction; molecular mechanisms; pathogen-vector interactions
المشرفين على المادة: 0 (Insect Hormones)
0 (adipokinetic hormone)
SZB83O1W42 (Pyrrolidonecarboxylic Acid)
0 (MicroRNAs)
0 (Juvenile Hormones)
0 (Insect Proteins)
0 (Oligopeptides)
SCR Organism: Candidatus Liberibacter asiaticus; Diaphorina citri
تواريخ الأحداث: Date Created: 20240710 Date Completed: 20240710 Latest Revision: 20240712
رمز التحديث: 20240712
مُعرف محوري في PubMed: PMC11236419
DOI: 10.7554/eLife.93450
PMID: 38985571
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-084X
DOI:10.7554/eLife.93450