دورية أكاديمية
MicroRNA-532 as a probable diagnostic and therapeutic marker in cancer patients.
| العنوان: | MicroRNA-532 as a probable diagnostic and therapeutic marker in cancer patients. |
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| المؤلفون: | Lotfi M; Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran., Maharati A; Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Hamidi AA; Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran., Taghehchian N; Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran., Moghbeli M; Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: Meysam_moghbeli@yahoo.com. |
| المصدر: | Mutation research [Mutat Res] 2024 Jul 08; Vol. 829, pp. 111874. Date of Electronic Publication: 2024 Jul 08. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0400763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-135X (Electronic) Linking ISSN: 00275107 NLM ISO Abbreviation: Mutat Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier, [1964- |
| مستخلص: | The high mortality rate in cancer patients is always one of the main challenges of the health systems globally. Several factors are involved in the high rate of cancer related mortality, including late diagnosis and drug resistance. Cancer is mainly diagnosed in the advanced stages of tumor progression that causes the failure of therapeutic strategies and increases the death rate in these patients. Therefore, assessment of the molecular mechanisms associated with the occurrence of cancer can be effective to introduce early tumor diagnostic markers. MicroRNAs (miRNAs) as the stable non-coding RNAs in the biological body fluids are involved in regulation of cell proliferation, migration, and apoptosis. MiR-532 deregulation has been reported in different tumor types. Therefore, in the present review we discussed the role of miR-532 during tumor growth. It has been shown that miR-532 has mainly a tumor suppressor role through the regulation of transcription factors, chemokines, and signaling pathways such as NF-kB, MAPK, PI3K/AKT, and WNT. In addition to the independent role of miR-532 in regulation of cellular processes, it also functions as a mediator of lncRNAs and circRNAs. Therefore, miR-532 can be considered as a non-invasive diagnostic/prognostic marker as well as a therapeutic target in cancer patients. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Cancer; Diagnosis; MicroRNA-532; Non-invasive marker; Prognosis |
| تواريخ الأحداث: | Date Created: 20240710 Latest Revision: 20240710 |
| رمز التحديث: | 20240711 |
| DOI: | 10.1016/j.mrfmmm.2024.111874 |
| PMID: | 38986233 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1873-135X |
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| DOI: | 10.1016/j.mrfmmm.2024.111874 |