دورية أكاديمية
Edaravone combined with hyperbaric oxygen therapy in delayed encephalopathy after acute carbon monoxide poisoning: A meta-analysis.
| العنوان: | Edaravone combined with hyperbaric oxygen therapy in delayed encephalopathy after acute carbon monoxide poisoning: A meta-analysis. |
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| المؤلفون: | Zeng S; Harbin Medical University Graduate School, Harbin Medical University, Heilongjiang Province, Harbin 150086, China., Li Y; Department of Critical Care Medicine, the Second Affiliated Hospital of Harbin Medical University, Heilongjiang Province, Harbin 150086, China., Yao Z; Department of Critical Care Medicine, the Second Affiliated Hospital of Harbin Medical University, Heilongjiang Province, Harbin 150086, China., Li Y; Department of Critical Care Medicine, the Second Affiliated Hospital of Harbin Medical University, Heilongjiang Province, Harbin 150086, China., Cao Y; Department of Critical Care Medicine, the Second Affiliated Hospital of Harbin Medical University, Heilongjiang Province, Harbin 150086, China., Wen L; Department of Critical Care Medicine, the Second Affiliated Hospital of Harbin Medical University, Heilongjiang Province, Harbin 150086, China., Li M; Department of Critical Care Medicine, the Second Affiliated Hospital of Harbin Medical University, Heilongjiang Province, Harbin 150086, China., Zheng J; Department of Critical Care Medicine, the Second Affiliated Hospital of Harbin Medical University, Heilongjiang Province, Harbin 150086, China. Electronic address: icuzhengjunbo@126.com., Wang H; Department of Critical Care Medicine, the Second Affiliated Hospital of Harbin Medical University, Heilongjiang Province, Harbin 150086, China. Electronic address: icuwanghongliang@163.com. |
| المصدر: | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia [J Clin Neurosci] 2024 Aug; Vol. 126, pp. 270-283. Date of Electronic Publication: 2024 Jul 09. |
| نوع المنشور: | Journal Article; Meta-Analysis; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 9433352 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2653 (Electronic) Linking ISSN: 09675868 NLM ISO Abbreviation: J Clin Neurosci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2000->: Edinburgh : Churchill Livingstone Original Publication: Melbourne, Vic., Australia : Churchill Livingstone, c1994- |
| مواضيع طبية MeSH: | Hyperbaric Oxygenation*/methods , Edaravone*/therapeutic use , Carbon Monoxide Poisoning*/complications , Carbon Monoxide Poisoning*/therapy, Humans ; Combined Modality Therapy/methods ; Brain Diseases/etiology ; Brain Diseases/therapy ; Randomized Controlled Trials as Topic ; Free Radical Scavengers/therapeutic use |
| مستخلص: | Background: The use of both edaravone (EDA) and hyperbaric oxygen therapy (HBOT) is increasingly prevalent in the treatment of delayed encephalopathy after carbon monoxide poisoning (DEACMP). This meta-analysis aims to evaluate the efficacy of using EDA and HBOT in combination with HBOT alone in the treatment of DEACMP. Methods: We searched and included all randomized controlled trials (RCTs) published before November 6, 2023, from 12 Chinese and English databases and clinical trial centers in China and the United States. The main outcome indicator was the total effective rate. The secondary outcome indicators included the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), National Institutes of Health Stroke Scale (NIHSS), Barthel Index (BI), Hasegawa Dementia Scale (HDS), Fugl-Meyer Assessment (FMA), Superoxide Dismutase (SOD), and Malondialdehyde (MDA). Statistical measures utilized include risk ratios (RR), weighted mean difference (WMD), and 95 % confidence intervals (95 % CI). Results: Thirty studies involving a combined total of 2075 participants were ultimately incorporated. It was observed that the combination of EDA with HBOT for the treatment of DEACMP demonstrated an improvement in the total effective rate (RR: 1.25; 95 % CI: 1.20-1.31; P < 0.01), MMSE (WMD: 3.67; 95 % CI: 2.59-4.76; P < 0.01), MoCA (WMD: 4.38; 95 % CI: 4.00-4.76; P < 0.01), BI (WMD: 10.94; 95 % CI: 5.23-16.66; P < 0.01), HDS (WMD: 6.80; 95 % CI: 4.05-9.55; P < 0.01), FMA (WMD: 8.91; 95 % CI: 7.22-10.60; P < 0.01), SOD (WMD: 18.45; 95 % CI: 16.93-19.98; P < 0.01); and a reduction in NIHSS (WMD: -4.12; 95 % CI: -4.93 to -3.30; P < 0.01) and MDA (WMD: -3.05; 95 % CI: -3.43 to -2.68; P < 0.01). Conclusion: Low-quality evidence suggests that for DEACMP, compared to using HBOT alone, the combined use of EDA and HBOT may be associated with better cognition and activity of daily living. In the future, conducting more meticulously designed multicenter and large-sample RCTs to substantiate our conclusions is essential. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024. Published by Elsevier Ltd.) |
| فهرسة مساهمة: | Keywords: ACMP; Acute carbon monoxide poisoning; DEACMP; Delayed encephalopathy after acute carbon monoxide poisoning; EDA; Edaravone; HBOT; Hyperbaric oxygen therapy; Meta-analysis |
| المشرفين على المادة: | S798V6YJRP (Edaravone) 0 (Free Radical Scavengers) |
| تواريخ الأحداث: | Date Created: 20240710 Date Completed: 20240803 Latest Revision: 20240803 |
| رمز التحديث: | 20240804 |
| DOI: | 10.1016/j.jocn.2024.06.018 |
| PMID: | 38986338 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1532-2653 |
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| DOI: | 10.1016/j.jocn.2024.06.018 |