دورية أكاديمية
أعرض في EDS

Copeptin's role in traumatic brain injury: The promising quest for a new biomarker.

التفاصيل البيبلوغرافية
العنوان: Copeptin's role in traumatic brain injury: The promising quest for a new biomarker.
المؤلفون: Săcărescu A; Department of Medical Specialties III, 'Grigore T. Popa' University of Medicine and Pharmacy, Universității 16, Iași 700115, Romania; Department of Neurology, Clinical Rehabilitation Hospital, Pantelimon Halipa 14, Iași 700661, Romania. Electronic address: alina-l-sacarescu@d.umfiasi.ro., Pleşca IC; Faculty of Mathematics, 'Alexandru Ioan Cuza' University, Bulevardul Carol I 11, Iași 700506, Romania., Turliuc MD; Department of Surgery II, 'Grigore T. Popa' University of Medicine and Pharmacy, Universității 16, Iași 700115, Romania; Department of Neurosurgery I, 'Prof. Dr. N. Oblu' Clinical Emergency Hospital, Ateneului 2, Iași 700309, Romania.
المصدر: Clinical neurology and neurosurgery [Clin Neurol Neurosurg] 2024 Sep; Vol. 244, pp. 108432. Date of Electronic Publication: 2024 Jul 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7502039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6968 (Electronic) Linking ISSN: 03038467 NLM ISO Abbreviation: Clin Neurol Neurosurg Subsets: MEDLINE
أسماء مطبوعة: Publication: Amsterdam : Elsevier
Original Publication: Assen, Van Gorcum.
مواضيع طبية MeSH: Brain Injuries, Traumatic*/blood , Brain Injuries, Traumatic*/diagnosis , Glycopeptides*/blood , Biomarkers*/blood, Humans ; Male ; Female ; Adult ; Middle Aged ; Cross-Sectional Studies ; Aged ; Glasgow Coma Scale ; Young Adult ; Vasopressins/blood ; Adolescent
مستخلص: Objective: Traumatic brain injury (TBI) necessitates reliable biomarkers to improve patient care. This study explored copeptin as a potential biomarker in TBI and its relation to vasopressin (ADH) in such patients.
Methods: A cross-sectional study was conducted on 50 TBI patients. Exclusion criteria included specific medical conditions and recent traumatic events. Copeptin and ADH testing were performed within 30 days post-trauma. Patient data, Glasgow Coma Scale (GCS) scores, imaging results, and the need for surgical intervention were obtained from medical charts.
Results: Copeptin levels negatively correlated with GCS scores (ρ = - 0.313, p = 0.027), indicating a potential association with trauma severity. Copeptin levels (mean: 3.22 pmol/L, median 2.027 pmol/L, SD = 3.15) tended to be lower than those found in the normal population, suggesting possible neuroendocrine dysfunction post-TBI. ADH levels (mean: 67.93 pmol/L, median 56.474 pmol/L SD = 47.67) were higher than the normal range and associated with the need for surgery (p = 0.048). Surprisingly, copeptin and ADH levels negatively correlated (r = - 0.491; p < 0.001), potentially due to differences in degradation processes and physiological variations in TBI patients.
Conclusion: Copeptin shows potential as a predictive biomarker for assessing TBI severity and predicting patient outcome. However, its complex relationship with ADH in TBI requires further investigation. Careful interpretation is needed due to potential variations in excretion dynamics and metabolism. Larger studies on TBI patient cohorts are essential to validate copeptin as a reliable biomarker and improve patient care in TBI.
Competing Interests: Declaration of interest None.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Antidiuretic hormone; Biomarker; Copeptin; Traumatic brain injury; Vasopressin
المشرفين على المادة: 0 (copeptins)
0 (Glycopeptides)
0 (Biomarkers)
11000-17-2 (Vasopressins)
تواريخ الأحداث: Date Created: 20240710 Date Completed: 20240808 Latest Revision: 20240808
رمز التحديث: 20240809
DOI: 10.1016/j.clineuro.2024.108432
PMID: 38986366
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-6968
DOI:10.1016/j.clineuro.2024.108432