دورية أكاديمية
Recording of single-unit activities with flexible micro-electrocorticographic array in rats for decoding of whole-body navigation.
| العنوان: | Recording of single-unit activities with flexible micro-electrocorticographic array in rats for decoding of whole-body navigation. |
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| المؤلفون: | Lo YT; Department of Neurosurgery, National Neuroscience Institute, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore., Jiang L; Department of Orthopaedic Surgery, Singapore General Hospital, Singapore, Singapore., Woodington B; Opto Biosystems Ltd, Cambridge, United Kingdom., Middya S; Opto Biosystems Ltd, Cambridge, United Kingdom., Braendlein M; Opto Biosystems Ltd, Cambridge, United Kingdom., Lam JLW; Department of Neurosurgery, University of Michigan, Ann Arbor, MI, United States of America., Lim MJR; Department of Neurosurgery, National University Hospital, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Ng VYP; Department of Neurosurgery, National Neuroscience Institute, Singapore, Singapore., Rao JP; Duke-NUS Medical School, Singapore, Singapore.; Department of Neurosurgery, Singapore General Hospital, Singapore, Singapore., Chan DWS; Department of Neurology, KK Women's and Children's Hospital, Singapore, Singapore., Ang BT; Department of Neurosurgery, Singapore General Hospital, Singapore, Singapore. |
| المصدر: | Journal of neural engineering [J Neural Eng] 2024 Aug 05; Vol. 21 (4). Date of Electronic Publication: 2024 Aug 05. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Institute of Physics Pub Country of Publication: England NLM ID: 101217933 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-2552 (Electronic) Linking ISSN: 17412552 NLM ISO Abbreviation: J Neural Eng Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bristol, U.K. : Institute of Physics Pub., 2004- |
| مواضيع طبية MeSH: | Rats, Wistar* , Electrocorticography*/methods , Electrocorticography*/instrumentation , Motor Cortex*/physiology , Electrodes, Implanted*, Animals ; Rats ; Male ; Microelectrodes ; Action Potentials/physiology ; Equipment Design/methods ; Spatial Navigation/physiology ; Brain-Computer Interfaces ; Equipment Failure Analysis/methods |
| مستخلص: | Objective. Micro-electrocorticographic ( μ ECoG) arrays are able to record neural activities from the cortical surface, without the need to penetrate the brain parenchyma. Owing in part to small electrode sizes, previous studies have demonstrated that single-unit spikes could be detected from the cortical surface, and likely from Layer I neurons of the neocortex. Here we tested the ability to use μ ECoG arrays to decode, in rats, body position during open field navigation, through isolated single-unit activities. Approach. μ ECoG arrays were chronically implanted onto primary motor cortex (M1) of Wistar rats, and neural recording was performed in awake, behaving rats in an open-field enclosure. The signals were band-pass filtered between 300-3000 Hz. Threshold-crossing spikes were identified and sorted into distinct units based on defined criteria including waveform morphology and refractory period. Body positions were derived from video recordings. We used gradient-boosting machine to predict body position based on previous 100 ms of spike data, and correlation analyses to elucidate the relationship between position and spike patterns. Main results. Single-unit spikes could be extracted during chronic recording from μ ECoG, and spatial position could be decoded from these spikes with a mean absolute error of prediction of 0.135 and 0.090 in the x- and y- dimensions (of a normalized range from 0 to 1), and Pearson's r of 0.607 and 0.571, respectively. Significance. μ ECoG can detect single-unit activities that likely arise from superficial neurons in the cortex and is a promising alternative to intracortical arrays, with the added benefit of scalability to cover large cortical surface with minimal incremental risks. More studies should be performed in human related to its use as brain-machine interface. (Creative Commons Attribution license.) |
| فهرسة مساهمة: | Keywords: brain–computer interface; brain–machine interface; electrocorticography; single-unit activity; spike; μECoG |
| تواريخ الأحداث: | Date Created: 20240710 Date Completed: 20240805 Latest Revision: 20240805 |
| رمز التحديث: | 20240805 |
| DOI: | 10.1088/1741-2552/ad618c |
| PMID: | 38986465 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1741-2552 |
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| DOI: | 10.1088/1741-2552/ad618c |