دورية أكاديمية
Association between specific IgE to staphylococcal enterotoxin B and the eosinophilic phenotype of asthma.
| العنوان: | Association between specific IgE to staphylococcal enterotoxin B and the eosinophilic phenotype of asthma. |
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| المؤلفون: | Sim S; Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea., Choi Y; Department of Biomaterials Science (BK21 FOUR Program), College of Natural Resources and Life Science, Pusan National University, Miryang, Korea., Yang EM; Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea., Park HS; Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea. |
| المصدر: | The Korean journal of internal medicine [Korean J Intern Med] 2024 Jul; Vol. 39 (4), pp. 659-667. Date of Electronic Publication: 2024 Jul 01. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Korean Association of Internal Medicine Country of Publication: Korea (South) NLM ID: 8712418 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2005-6648 (Electronic) Linking ISSN: 12263303 NLM ISO Abbreviation: Korean J Intern Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Seoul] : Korean Association of Internal Medicine |
| مواضيع طبية MeSH: | Enterotoxins*/immunology , Immunoglobulin E*/blood , Asthma*/immunology , Asthma*/blood , Asthma*/diagnosis , Phenotype* , Eosinophils*/immunology , Superantigens*/immunology , Superantigens*/blood, Humans ; Male ; Female ; Middle Aged ; Adult ; Case-Control Studies ; Biomarkers/blood ; Aged ; Eosinophilia/immunology ; Eosinophilia/blood ; Eosinophilia/diagnosis ; Eosinophil Cationic Protein/blood ; Bacterial Toxins/immunology ; Bacterial Toxins/blood ; Eosinophil-Derived Neurotoxin/blood |
| مستخلص: | Background/aims: Sensitization to staphylococcal superantigens (SAgs) could contribute to asthma severity. However, its relevance with eosinophilic phenotype has not yet been clarified. This study aimed to investigate associations between serum specific IgE levels to SAg and eosinophilic airway inflammation in adult asthmatics. Methods: The serum specific IgE levels to 3 SAgs, including staphylococcal enterotoxin A (SEA) and B (SEB), and toxic shock syndrome toxin-1 (TSST-1) were measured by ImmunoCAP in 230 adult asthmatic patients and 50 healthy controls (HCs). Clinical characteristics and laboratory parameters, including serum total/free IgE, and 2 eosinophil-activation markers, eosinophil cationic protein (ECP), and eosinophil-derived neurotoxin (EDN), were analyzed according to blood eosinophil counts (BEC; 150 cells/μL) and serum specific IgE levels to 3 SAgs (0.35 kU/L). Results: Asthmatic patients showed higher serum specific IgE levels to 3 SAgs than HCs (p < 0.05 for all). The serum total/clinfree IgE levels were significantly higher in asthmatics with positive IgE responses to 3 SAgs than those without (p < 0.05 for all). There were no significant differences in clinical parameters including age, asthma severity, comorbidities, or smoking according to IgE responses to 3 SAgs. Patients with positive IgE responses to SEB (not to SEA/TSST-1) had higher serum specific IgE levels to house dust mites and ECP/EDN as well as higher BEC with positive correlations between serum SEB-specific IgE levels and BEC/ECP/EDN (p < 0.05 for all). Conclusion: These findings suggest that serum SEB-specific IgE levels could contribute to eosinophil activation as well as IgE production in adult asthma. |
| التعليقات: | Comment in: Korean J Intern Med. 2024 Jul;39(4):543-544. doi: 10.3904/kjim.2024.216. (PMID: 38986493) |
| References: | Ann Allergy Asthma Immunol. 2015 Sep;115(3):191-197.e2. (PMID: 26208759) Respir Med. 2007 Apr;101(4):696-705. (PMID: 17034998) Clin Exp Allergy. 2010 Jul;40(7):1079-90. (PMID: 20214664) Tuberc Respir Dis (Seoul). 2016 Oct;79(4):295-301. (PMID: 27790282) J Investig Allergol Clin Immunol. 2021 Apr 20;31(2):170-173. (PMID: 32694100) Exp Mol Med. 2018 Aug 16;50(8):1-8. (PMID: 30115903) Allergy Asthma Immunol Res. 2019 May;11(3):394-405. (PMID: 30912328) J Intern Med. 2012 Aug;272(2):133-43. (PMID: 22640264) Annu Rev Immunol. 1999;17:435-66. (PMID: 10358765) Life Sci. 2021 Jan 1;264:118685. (PMID: 33137369) Clin Rev Allergy Immunol. 2019 Apr;56(2):219-233. (PMID: 30206782) BMC Pulm Med. 2023 Mar 22;23(1):96. (PMID: 36949398) J Asthma Allergy. 2016 Jan 07;9:1-12. (PMID: 26793004) Allergy. 2011 Jan;66(1):141-8. (PMID: 20659077) J Allergy Clin Immunol. 2024 Mar;153(3):718-731.e11. (PMID: 38056634) Immune Netw. 2022 Dec 05;22(6):e45. (PMID: 36627938) Respir Med. 2019 Aug;155:66-71. (PMID: 31302581) J Pediatr. 2008 Dec;153(6):803-6. (PMID: 18621391) J Bras Pneumol. 2016 Sep-Oct;42(5):356-361. (PMID: 27812635) Ann Am Thorac Soc. 2018 Mar;15(3):348-356. (PMID: 29323930) Ann Allergy Asthma Immunol. 2017 Feb;118(2):197-203. (PMID: 28034578) Respir Res. 2018 Jun 8;19(1):113. (PMID: 29879991) Front Cell Infect Microbiol. 2012 Apr 17;2:52. (PMID: 22919643) N Engl J Med. 1998 Aug 20;339(8):520-32. (PMID: 9709046) Allergy Asthma Immunol Res. 2023 Mar;15(2):119-121. (PMID: 37021499) Eur Respir J. 2020 Jan 2;55(1):. (PMID: 31558662) Front Med (Lausanne). 2017 Jun 30;4:93. (PMID: 28713812) Clin Exp Allergy. 2018 Sep;48(9):1137-1146. (PMID: 29781543) J Allergy Clin Immunol. 2017 Jun;139(6):1849-1860.e6. (PMID: 28216437) Korean J Intern Med. 2020 Jul;35(4):823-833. (PMID: 32460456) Allergy Asthma Immunol Res. 2014 May;6(3):263-6. (PMID: 24843803) Ann Allergy Asthma Immunol. 2021 Jul;127(1):109-115.e1. (PMID: 33785460) J Allergy Clin Immunol Pract. 2023 Oct;11(10):3055-3061.e4. (PMID: 37301436) Clin Exp Allergy. 2016 Mar;46(3):411-21. (PMID: 26436720) Clin Exp Allergy. 2006 Aug;36(8):1063-71. (PMID: 16911362) J Allergy Clin Immunol. 2012 Aug;130(2):376-81.e8. (PMID: 22738677) Allergy. 2020 Jan;75(1):95-103. (PMID: 31330043) Toxins (Basel). 2020 Mar 12;12(3):. (PMID: 32178378) J Allergy Clin Immunol Pract. 2017 Jan - Feb;5(1):144-153.e8. (PMID: 27665383) Allergy. 2011 Jan;66(1):32-8. (PMID: 20973803) |
| معلومات مُعتمدة: | Korea Health Industry Development Institute; HR16C0001 Ministry of Health and Welfare |
| فهرسة مساهمة: | Keywords: Asthma; Eosinophil; IgE; Staphylococcus aureus; Superantigen |
| المشرفين على المادة: | 0 (Enterotoxins) 37341-29-0 (Immunoglobulin E) 39424-53-8 (enterotoxin B, staphylococcal) 0 (Superantigens) 0 (Biomarkers) EC 3.1.27.- (Eosinophil Cationic Protein) EC 3.1.27.- (RNASE3 protein, human) 0 (Bacterial Toxins) 0 (enterotoxin F, Staphylococcal) EC 3.1.- (Eosinophil-Derived Neurotoxin) |
| تواريخ الأحداث: | Date Created: 20240710 Date Completed: 20240710 Latest Revision: 20240714 |
| رمز التحديث: | 20240714 |
| مُعرف محوري في PubMed: | PMC11236811 |
| DOI: | 10.3904/kjim.2024.003 |
| PMID: | 38986495 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2005-6648 |
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| DOI: | 10.3904/kjim.2024.003 |