دورية أكاديمية
أعرض في EDS

Bisphenol S causes excessive estrogen synthesis by activating FSHR and the downstream cAMP/PKA signaling pathway.

التفاصيل البيبلوغرافية
العنوان: Bisphenol S causes excessive estrogen synthesis by activating FSHR and the downstream cAMP/PKA signaling pathway.
المؤلفون: Zhang X; College of Marine Life Sciences, Ocean University of China, 266003, Qingdao, Shandong Province, China.; Tai'an Agriculture and Rural Affairs Bureau, 271000, Tai'an, Shandong Province, China., Zhang X; College of Marine Life Sciences, Ocean University of China, 266003, Qingdao, Shandong Province, China., Zhang Z; College of Marine Life Sciences, Ocean University of China, 266003, Qingdao, Shandong Province, China., Shi Y; College of Marine Life Sciences, Ocean University of China, 266003, Qingdao, Shandong Province, China., Wang J; College of Marine Life Sciences, Ocean University of China, 266003, Qingdao, Shandong Province, China., Ru S; College of Marine Life Sciences, Ocean University of China, 266003, Qingdao, Shandong Province, China., Tian H; College of Marine Life Sciences, Ocean University of China, 266003, Qingdao, Shandong Province, China. tianhua@ouc.edu.cn.
المصدر: Communications biology [Commun Biol] 2024 Jul 10; Vol. 7 (1), pp. 844. Date of Electronic Publication: 2024 Jul 10.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London, United Kingdom : Nature Publishing Group UK, [2018]-
مواضيع طبية MeSH: Phenols*/toxicity , Cyclic AMP-Dependent Protein Kinases*/metabolism , Cyclic AMP*/metabolism , Signal Transduction*/drug effects , Estrogens*/metabolism , Receptors, FSH*/metabolism , Receptors, FSH*/genetics , Sulfones*/pharmacology, Humans ; Female ; Estradiol/metabolism ; Granulosa Cells/metabolism ; Granulosa Cells/drug effects
مستخلص: Estrogen excess in females has been linked to a diverse array of chronic and acute diseases. Emerging research shows that exposure to estrogen-like compounds such as bisphenol S leads to increases in 17β-estradiol levels, but the mechanism of action is unclear. The aim of this study was to reveal the underlying signaling pathway-mediated mechanisms, target site and target molecule of action of bisphenol S causing excessive estrogen synthesis. Human ovarian granulosa cells SVOG were exposed to bisphenol S at environmentally relevant concentrations (1 μg/L, 10 μg/L, and 100 μg/L) for 48 h. The results confirms that bisphenol S accumulates mainly on the cell membrane, binds to follicle stimulating hormone receptor (FSHR) located on the cell membrane, and subsequently activates the downstream cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) signaling pathway, leading to enhanced conversion of testosterone to 17β-estradiol. This study deepens our knowledge of the mechanisms of environmental factors in pathogenesis of hyperestrogenism.
(© 2024. The Author(s).)
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معلومات مُعتمدة: 41976139 National Natural Science Foundation of China (National Science Foundation of China)
المشرفين على المادة: 0 (Phenols)
EC 2.7.11.11 (Cyclic AMP-Dependent Protein Kinases)
E0399OZS9N (Cyclic AMP)
80-09-1 (bisphenol S)
0 (Estrogens)
0 (Receptors, FSH)
0 (Sulfones)
4TI98Z838E (Estradiol)
تواريخ الأحداث: Date Created: 20240710 Date Completed: 20240710 Latest Revision: 20240714
رمز التحديث: 20240714
مُعرف محوري في PubMed: PMC11237073
DOI: 10.1038/s42003-024-06449-2
PMID: 38987655
قاعدة البيانات: MEDLINE
الوصف
تدمد:2399-3642
DOI:10.1038/s42003-024-06449-2