دورية أكاديمية
Electroencephalographic and Behavioral Effects of Intranasal Administration of a Na + , K + -ATPase-Activating Antibody after Status Epilepticus.
| العنوان: | Electroencephalographic and Behavioral Effects of Intranasal Administration of a Na + , K + -ATPase-Activating Antibody after Status Epilepticus. |
|---|---|
| المؤلفون: | Mello FK; Graduate Program in Pharmacology, Federal University of Santa Maria, Santa Maria 97105-900, Brazil., Sampaio TB; Graduate Program in Pharmacology, Federal University of Santa Maria, Santa Maria 97105-900, Brazil., Neuberger B; Graduate Program in Pharmacology, Federal University of Santa Maria, Santa Maria 97105-900, Brazil., Mallmann MP; Graduate Program in Pharmacology, Federal University of Santa Maria, Santa Maria 97105-900, Brazil., Fighera MR; Department of Neuropsychiatry, Federal University of Santa Maria, Santa Maria 97105-900, Brazil., Royes LFF; Department of Sports Methods and Techniques, Federal University of Santa Maria, Santa Maria 97105-900, Brazil., Furian AF; Graduate Program in Pharmacology, Federal University of Santa Maria, Santa Maria 97105-900, Brazil., Larrick JW; Panorama Research Institute, 1230 Bordeaux Dr., Sunnyvale, California 94089, United States., Oliveira MS; Graduate Program in Pharmacology, Federal University of Santa Maria, Santa Maria 97105-900, Brazil. |
| المصدر: | ACS chemical neuroscience [ACS Chem Neurosci] 2024 Aug 07; Vol. 15 (15), pp. 2695-2702. Date of Electronic Publication: 2024 Jul 11. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, D.C. : American Chemical Society |
| مواضيع طبية MeSH: | Status Epilepticus*/chemically induced , Status Epilepticus*/drug therapy , Administration, Intranasal* , Sodium-Potassium-Exchanging ATPase*/metabolism , Pilocarpine*/pharmacology , Electroencephalography*/methods , Electroencephalography*/drug effects, Animals ; Male ; Rats ; Behavior, Animal/drug effects ; Disease Models, Animal ; Rats, Wistar ; Antibodies/pharmacology ; Antibodies/administration & dosage |
| مستخلص: | Status epilepticus (SE) is a medical emergency associated with high mortality and morbidity. Na + , K + -ATPase, is a promising therapeutic target for SE, given its critical role in regulation of neuron excitability and cellular homeostasis. We investigated the effects of a Na + , K + -ATPase-activating antibody (DRRSAb) on short-term electrophysiological and behavioral consequences of pilocarpine-induced SE. Rats were submitted to pilocarpine-induced SE, followed by intranasal administration (2 μg/nostril). The antibody increased EEG activity following SE, namely, EEG power in theta, beta, and gamma frequency bands, assessed by quantitative analysis of EEG power spectra. One week later, DRRSAb-treated animals displayed less behavioral hyperreactivity in pick-up tests and better performance in novel object recognition tests, indicating that the intranasal administration of this Na + , K + -ATPase activator immediately after SE improves behavioral outcomes at a later time point. These results suggest that Na + , K + -ATPase activation warrants further investigation as an adjunctive therapeutic strategy for SE. |
| References: | Proc Natl Acad Sci U S A. 2023 Sep 12;120(37):e2309221120. (PMID: 37669383) Neurosci Lett. 2009 Apr 10;453(3):233-7. (PMID: 19429042) Cardiovasc Res. 2011 Jan 1;89(1):51-9. (PMID: 20724308) Neuroreport. 1995 Dec 29;7(1):333-7. (PMID: 8742483) Neurology. 2011 Jan 18;76(3):287-93. (PMID: 21242497) Arch Neurol. 1975 Aug;32(8):549-54. (PMID: 125576) Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2200057120. (PMID: 36649432) Sci Rep. 2016 Jun 27;6:28599. (PMID: 27345430) J Neurochem. 2002 Jul;82(1):192-201. (PMID: 12091480) Nat Commun. 2022 Nov 21;13(1):7136. (PMID: 36414629) Epilepsia. 2014 Apr;55(4):475-82. (PMID: 24730690) Brain Res. 2022 Jun 1;1784:147883. (PMID: 35300975) Neurol Res. 2017 Aug;39(8):667-674. (PMID: 28468601) J Neurophysiol. 1990 Feb;63(2):225-39. (PMID: 2313342) Future Neurol. 2009 Sep 1;4(5):663-668. (PMID: 20161538) Seizure. 2017 Jan;44:65-73. (PMID: 27890484) Neurochem Int. 1996 May-Jun;28(5-6):497-500. (PMID: 8792330) Brain Res. 1983 Feb 14;261(1):75-84. (PMID: 6301630) Epilepsy Res. 2014 Dec;108(10):1705-10. (PMID: 25311690) Lancet. 2015 Mar 7;385(9971):884-98. (PMID: 25260236) Biochem Biophys Res Commun. 2005 Dec 30;338(4):1669-77. (PMID: 16263081) Neurochem Int. 2013 Nov;63(6):583-93. (PMID: 24076474) Sci Rep. 2017 May 12;7(1):1862. (PMID: 28500326) J Neurosci. 2007 Jan 3;27(1):251-9. (PMID: 17202493) Neuroscience. 2015 Jul 9;298:171-9. (PMID: 25907445) Epilepsy Behav Rep. 2022 Dec 28;21:100581. (PMID: 36636458) J Am Soc Nephrol. 2012 Aug;23(8):1283-90. (PMID: 22745476) Epilepsy Behav. 2002 Aug;3(4):395-401. (PMID: 12609340) Neuropeptides. 2010 Apr;44(2):169-76. (PMID: 20064661) Neuropharmacology. 1970 Sep;9(5):441-9. (PMID: 5477429) Neuroscience. 2018 May 1;377:98-104. (PMID: 29522855) Lancet Neurol. 2016 Jul;15(8):843-856. (PMID: 27302363) |
| فهرسة مساهمة: | Keywords: DRRSAb; EEG; Epilepsy; neuroprotection; nose-to-brain delivery; pilocarpine |
| المشرفين على المادة: | EC 7.2.2.13 (Sodium-Potassium-Exchanging ATPase) 01MI4Q9DI3 (Pilocarpine) 0 (Antibodies) |
| تواريخ الأحداث: | Date Created: 20240711 Date Completed: 20240807 Latest Revision: 20240811 |
| رمز التحديث: | 20240812 |
| مُعرف محوري في PubMed: | PMC11311123 |
| DOI: | 10.1021/acschemneuro.4c00141 |
| PMID: | 38989663 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1948-7193 |
|---|---|
| DOI: | 10.1021/acschemneuro.4c00141 |