دورية أكاديمية
Electroencephalographic and Behavioral Effects of Intranasal Administration of a Na + , K + -ATPase-Activating Antibody after Status Epilepticus.
العنوان: | Electroencephalographic and Behavioral Effects of Intranasal Administration of a Na + , K + -ATPase-Activating Antibody after Status Epilepticus. |
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المؤلفون: | Mello FK; Graduate Program in Pharmacology, Federal University of Santa Maria, Santa Maria 97105-900, Brazil., Sampaio TB; Graduate Program in Pharmacology, Federal University of Santa Maria, Santa Maria 97105-900, Brazil., Neuberger B; Graduate Program in Pharmacology, Federal University of Santa Maria, Santa Maria 97105-900, Brazil., Mallmann MP; Graduate Program in Pharmacology, Federal University of Santa Maria, Santa Maria 97105-900, Brazil., Fighera MR; Department of Neuropsychiatry, Federal University of Santa Maria, Santa Maria 97105-900, Brazil., Royes LFF; Department of Sports Methods and Techniques, Federal University of Santa Maria, Santa Maria 97105-900, Brazil., Furian AF; Graduate Program in Pharmacology, Federal University of Santa Maria, Santa Maria 97105-900, Brazil., Larrick JW; Panorama Research Institute, 1230 Bordeaux Dr., Sunnyvale, California 94089, United States., Oliveira MS; Graduate Program in Pharmacology, Federal University of Santa Maria, Santa Maria 97105-900, Brazil. |
المصدر: | ACS chemical neuroscience [ACS Chem Neurosci] 2024 Aug 07; Vol. 15 (15), pp. 2695-2702. Date of Electronic Publication: 2024 Jul 11. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Washington, D.C. : American Chemical Society |
مواضيع طبية MeSH: | Status Epilepticus*/chemically induced , Status Epilepticus*/drug therapy , Administration, Intranasal* , Sodium-Potassium-Exchanging ATPase*/metabolism , Pilocarpine*/pharmacology , Electroencephalography*/methods , Electroencephalography*/drug effects, Animals ; Male ; Rats ; Behavior, Animal/drug effects ; Disease Models, Animal ; Rats, Wistar ; Antibodies/pharmacology ; Antibodies/administration & dosage |
مستخلص: | Status epilepticus (SE) is a medical emergency associated with high mortality and morbidity. Na + , K + -ATPase, is a promising therapeutic target for SE, given its critical role in regulation of neuron excitability and cellular homeostasis. We investigated the effects of a Na + , K + -ATPase-activating antibody (DRRSAb) on short-term electrophysiological and behavioral consequences of pilocarpine-induced SE. Rats were submitted to pilocarpine-induced SE, followed by intranasal administration (2 μg/nostril). The antibody increased EEG activity following SE, namely, EEG power in theta, beta, and gamma frequency bands, assessed by quantitative analysis of EEG power spectra. One week later, DRRSAb-treated animals displayed less behavioral hyperreactivity in pick-up tests and better performance in novel object recognition tests, indicating that the intranasal administration of this Na + , K + -ATPase activator immediately after SE improves behavioral outcomes at a later time point. These results suggest that Na + , K + -ATPase activation warrants further investigation as an adjunctive therapeutic strategy for SE. |
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فهرسة مساهمة: | Keywords: DRRSAb; EEG; Epilepsy; neuroprotection; nose-to-brain delivery; pilocarpine |
المشرفين على المادة: | EC 7.2.2.13 (Sodium-Potassium-Exchanging ATPase) 01MI4Q9DI3 (Pilocarpine) 0 (Antibodies) |
تواريخ الأحداث: | Date Created: 20240711 Date Completed: 20240807 Latest Revision: 20240811 |
رمز التحديث: | 20240812 |
مُعرف محوري في PubMed: | PMC11311123 |
DOI: | 10.1021/acschemneuro.4c00141 |
PMID: | 38989663 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1948-7193 |
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DOI: | 10.1021/acschemneuro.4c00141 |