دورية أكاديمية
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An optimized cyclophosphamide-treated mouse model of Mycobacterium abscessus pulmonary infection.

التفاصيل البيبلوغرافية
العنوان: An optimized cyclophosphamide-treated mouse model of Mycobacterium abscessus pulmonary infection.
المؤلفون: Sun Y; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Zhang K; Antimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology Centre, Singapore, Singapore., Delos Santos M; Antimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology Centre, Singapore, Singapore., Pee CJE; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; Interdisciplinary Graduate Programme, Nanyang Technological University, Singapore, Singapore., Yang Y; Critical Analytics for Manufacturing of Personalized Medicine (CAMP) Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology Centre, Singapore, Singapore., Kang M; Critical Analytics for Manufacturing of Personalized Medicine (CAMP) Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology Centre, Singapore, Singapore., Shin SJ; Department of Microbiology, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, South Africa., Chan-Park MB; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore, Singapore.; Centre for Antimicrobial Bioengineering, Nanyang Technological University, Singapore, Singapore., Pethe K; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; Antimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology Centre, Singapore, Singapore.; Singapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, Singapore, Singapore.; National Centre for Infectious Diseases, Singapore, Singapore.
المصدر: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2024 Jul 11, pp. e0152023. Date of Electronic Publication: 2024 Jul 11.
Publication Model: Ahead of Print
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, American Society for Microbiology
مستخلص: Mycobacterium abscessus pulmonary infections are increasingly problematic, especially for immunocompromised individuals and those with underlying lung conditions. Currently, there is no reliable standardized treatment, underscoring the need for improved preclinical drug testing. We present a simplified immunosuppressed mouse model using only four injections of cyclophosphamide, which allows for sustained M. abscessus lung burden for up to 16 days. This model proved effective for antibiotic efficacy evaluation, as demonstrated with imipenem or amikacin.
فهرسة مساهمة: Keywords: M. abscessus; lung infection; mouse model
تواريخ الأحداث: Date Created: 20240711 Latest Revision: 20240711
رمز التحديث: 20240711
DOI: 10.1128/aac.01520-23
PMID: 38990014
قاعدة البيانات: MEDLINE
الوصف
تدمد:1098-6596
DOI:10.1128/aac.01520-23