دورية أكاديمية
أعرض في EDS

Glucose transporter 1 is essential for the resolution of methicillin-resistant S. aureus skin and soft tissue infections.

التفاصيل البيبلوغرافية
العنوان: Glucose transporter 1 is essential for the resolution of methicillin-resistant S. aureus skin and soft tissue infections.
المؤلفون: Banerjee SK; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, 450 Technology Drive, Pittsburgh, PA 15219, USA., Thurlow LR; Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7450, USA., Kannan K; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, 450 Technology Drive, Pittsburgh, PA 15219, USA., Richardson AR; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, 450 Technology Drive, Pittsburgh, PA 15219, USA. Electronic address: anthony.richardson@pitt.edu.
المصدر: Cell reports [Cell Rep] 2024 Jul 23; Vol. 43 (7), pp. 114486. Date of Electronic Publication: 2024 Jul 10.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, c 2012-
مواضيع طبية MeSH: Methicillin-Resistant Staphylococcus aureus* , Glucose Transporter Type 1*/metabolism , Glucose Transporter Type 1*/genetics , Soft Tissue Infections*/microbiology , Soft Tissue Infections*/metabolism , Soft Tissue Infections*/pathology, Animals ; Mice ; PPAR gamma/metabolism ; Staphylococcal Skin Infections/microbiology ; Staphylococcal Skin Infections/metabolism ; Staphylococcal Skin Infections/pathology ; Staphylococcal Skin Infections/drug therapy ; Mice, Inbred C57BL ; Macrophages/metabolism ; Macrophages/microbiology ; Staphylococcal Infections/metabolism ; Staphylococcal Infections/microbiology
مستخلص: Skin/soft tissue infections (SSTIs) caused by methicillin-resistant Staphylococcus aureus (MRSA) pose a major healthcare burden. Distinct inflammatory and resolution phases comprise the host immune response to SSTIs. Resolution is a myeloid PPARγ-dependent anti-inflammatory phase that is essential for the clearance of MRSA. However, the signals activating PPARγ to induce resolution remain unknown. Here, we demonstrate that myeloid glucose transporter 1 (GLUT-1) is essential for the onset of resolution. MRSA-challenged macrophages are unsuccessful in generating an oxidative burst or immune radicals in the absence of GLUT-1 due to a reduction in the cellular NADPH pool. This translates in vivo as a significant reduction in lipid peroxidation products required for the activation of PPARγ in MRSA-infected mice lacking myeloid GLUT-1. Chemical induction of PPARγ during infection circumvents this GLUT-1 requirement and improves resolution. Thus, GLUT-1-dependent oxidative burst is essential for the activation of PPARγ and subsequent resolution of SSTIs.
Competing Interests: Declaration of interests The authors declare no competing interests.
(Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: R01 AI093613 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: CP: Metabolism; CP: Microbiology; aureus; immunometabolism
المشرفين على المادة: 0 (Glucose Transporter Type 1)
0 (PPAR gamma)
تواريخ الأحداث: Date Created: 20240711 Date Completed: 20240728 Latest Revision: 20240815
رمز التحديث: 20240815
مُعرف محوري في PubMed: PMC11323221
DOI: 10.1016/j.celrep.2024.114486
PMID: 38990718
قاعدة البيانات: MEDLINE
الوصف
تدمد:2211-1247
DOI:10.1016/j.celrep.2024.114486