دورية أكاديمية
Integrated translation and metabolism in a partially self-synthesizing biochemical network.
العنوان: | Integrated translation and metabolism in a partially self-synthesizing biochemical network. |
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المؤلفون: | Giaveri S; Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany., Bohra N; Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany.; Max Planck School Matter to Life, Heidelberg, Germany., Diehl C; Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany., Yang HY; Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany.; Max Planck School Matter to Life, Heidelberg, Germany., Ballinger M; Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany., Paczia N; Core Facility for Metabolomics and Small Molecule Mass Spectrometry, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany., Glatter T; Facility for Mass Spectrometry and Proteomics, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany., Erb TJ; Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany.; SYNMIKRO Center for Synthetic Microbiology, Marburg, Germany. |
المصدر: | Science (New York, N.Y.) [Science] 2024 Jul 12; Vol. 385 (6705), pp. 174-178. Date of Electronic Publication: 2024 Jul 11. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Original Publication: New York, N.Y. : [s.n.] 1880- |
مواضيع طبية MeSH: | Carbon Dioxide*/metabolism , Cell-Free System* , Glycine*/biosynthesis , Glycine*/genetics , Metabolic Networks and Pathways* , Protein Biosynthesis*, Acyl Coenzyme A/metabolism ; Feedback, Physiological ; Gene Regulatory Networks |
مستخلص: | One of the hallmarks of living organisms is their capacity for self-organization and regeneration, which requires a tight integration of metabolic and genetic networks. We sought to construct a linked metabolic and genetic network in vitro that shows such lifelike behavior outside of a cellular context and generates its own building blocks from nonliving matter. We integrated the metabolism of the crotonyl-CoA/ethyl-malonyl-CoA/hydroxybutyryl-CoA cycle with cell-free protein synthesis using recombinant elements. Our network produces the amino acid glycine from CO |
المشرفين على المادة: | 0 (Acyl Coenzyme A) 142M471B3J (Carbon Dioxide) TE7660XO1C (Glycine) |
تواريخ الأحداث: | Date Created: 20240711 Date Completed: 20240711 Latest Revision: 20240712 |
رمز التحديث: | 20240713 |
DOI: | 10.1126/science.adn3856 |
PMID: | 38991083 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1095-9203 |
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DOI: | 10.1126/science.adn3856 |