دورية أكاديمية
أعرض في EDS

Ectopic fat in muscle and poor glycemic control are negatively associated with trabecular bone score in type 2 diabetes.

التفاصيل البيبلوغرافية
العنوان: Ectopic fat in muscle and poor glycemic control are negatively associated with trabecular bone score in type 2 diabetes.
المؤلفون: de Araújo IM; Department of Internal Medicine, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil. Electronic address: iana.araujo@usp.br., Salmon CEG; Department of Physics, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto da Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil., de Paula FJA; Department of Internal Medicine, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.
المصدر: Clinics (Sao Paulo, Brazil) [Clinics (Sao Paulo)] 2024 Jul 10; Vol. 79, pp. 100430. Date of Electronic Publication: 2024 Jul 10 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 101244734 Publication Model: eCollection Cited Medium: Internet ISSN: 1980-5322 (Electronic) Linking ISSN: 18075932 NLM ISO Abbreviation: Clinics (Sao Paulo) Subsets: MEDLINE
أسماء مطبوعة: Publication: 2022- : [New York] : Elsevier
Original Publication: São Paulo, SP : Hospital das Clínicas, Faculty of Medicine, University of São Paulo, [2005]-
مواضيع طبية MeSH: Diabetes Mellitus, Type 2*/physiopathology , Diabetes Mellitus, Type 2*/metabolism , Bone Density*/physiology , Cancellous Bone*/diagnostic imaging , Absorptiometry, Photon* , Muscle, Skeletal* , Adipose Tissue*/diagnostic imaging, Humans ; Male ; Female ; Middle Aged ; Case-Control Studies ; Adult ; Obesity/physiopathology ; Obesity/metabolism ; Glycated Hemoglobin/analysis ; Body Mass Index ; Aged ; Glycemic Control ; Reference Values
مستخلص: Introduction: Type 2 Diabetes (T2D) is associated with fractures, despite preserved Bone Mineral Density (BMD). This study aimed to evaluate the relationship between BMD and trabecular bone score (TBS) with the reallocation of fat within muscle in individuals with eutrophy, obesity, and T2D.
Methods: The subjects were divided into three groups: eutrophic controls paired by age and sex with the T2D group (n = 23), controls diagnosed with obesity paired by age, sex, and body mass index with the T2D group (n = 27), and the T2D group (n = 29). BMD and body fat percentage were determined using dual-energy X-Ray absorptiometry. TBS was determined using TBS iNsight software. Intra and extramyocellular lipids in the soleus were measured using proton magnetic resonance spectroscopy.
Results: TBS was lower in the T2D group than in the other two groups. Glycated hemoglobin (A1c) was negatively associated with TBS. Body fat percentage was negatively associated with TBS and Total Hip (TH) BMD. TH BMD was positively associated with intramuscular lipids. A trend of negative association was observed between intramuscular lipids and TBS.
Conclusion: This study showed for the first time that the reallocation of lipids within muscle has a negative association with TBS. Moreover, these results are consistent with previous studies showing a negative association between a parameter related to insulin resistance (intramuscular lipids) and TBS.
Competing Interests: Declaration of competing interest The authors declare no conflicts of interest.
(Copyright © 2024 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.)
References: Bone. 2015 Nov;80:109-114. (PMID: 26453500)
J Orthop Surg Res. 2011 Jun 15;6:30. (PMID: 21676245)
J Cell Biochem. 2006 Oct 1;99(2):411-24. (PMID: 16619259)
Nature. 2006 Dec 14;444(7121):881-7. (PMID: 17167477)
J Bone Miner Res. 2013 Aug;28(8):1721-8. (PMID: 23558967)
Braz J Med Biol Res. 2001 Sep;34(9):1139-45. (PMID: 11514837)
Bone. 2017 Aug;101:21-25. (PMID: 28390904)
J Bone Miner Res. 2010 Feb;25(2):292-7. (PMID: 19821769)
Osteoporos Int. 2020 Jun;31(6):1125-1133. (PMID: 32108240)
Arch Endocrinol Metab. 2022 Nov 11;66(5):633-641. (PMID: 36382752)
Curr Osteoporos Rep. 2020 Aug;18(4):357-370. (PMID: 32529455)
Nat Rev Endocrinol. 2017 Apr;13(4):208-219. (PMID: 27658727)
Lancet. 2018 Feb 10;391(10120):541-551. (PMID: 29221645)
Trends Endocrinol Metab. 2022 May;33(5):333-344. (PMID: 35307247)
Joint Bone Spine. 2013 Jan;80(1):8-10. (PMID: 22999894)
Am J Med. 2011 Nov;124(11):1043-50. (PMID: 22017783)
Cell. 2000 Jan 21;100(2):197-207. (PMID: 10660043)
Bone. 2019 Mar;120:212-218. (PMID: 30408611)
Compr Physiol. 2017 Dec 12;8(1):315-349. (PMID: 29357131)
Diabetes Care. 2019 Apr;42(4):507-513. (PMID: 30692240)
Calcif Tissue Int. 2022 Dec;111(6):587-596. (PMID: 36190530)
Nat Commun. 2023 Jan 17;14(1):266. (PMID: 36650173)
Diabetes Metab. 2019 Dec;45(6):505-516. (PMID: 30844447)
Braz J Med Biol Res. 2021 Dec 03;54(12):e11499. (PMID: 34878062)
Horm Metab Res. 2007 Dec;39(12):871-5. (PMID: 17960513)
Eur J Endocrinol. 2017 Jan;176(1):21-30. (PMID: 27707768)
Endocr Connect. 2019 Mar 1;8(3):R55-R70. (PMID: 30772871)
Calcif Tissue Int. 2014 Feb;94(2):223-31. (PMID: 24077896)
Arch Biochem Biophys. 2010 Nov 1;503(1):20-7. (PMID: 20599663)
PLoS One. 2019 Oct 15;14(10):e0223432. (PMID: 31613908)
فهرسة مساهمة: Keywords: Bone mineral Density; Dual-energy X-Ray Absorptiometry; Intramuscular lipids; Magnetic resonance
المشرفين على المادة: 0 (Glycated Hemoglobin)
تواريخ الأحداث: Date Created: 20240711 Date Completed: 20240715 Latest Revision: 20240804
رمز التحديث: 20240804
مُعرف محوري في PubMed: PMC11295920
DOI: 10.1016/j.clinsp.2024.100430
PMID: 38991370
قاعدة البيانات: MEDLINE
الوصف
تدمد:1980-5322
DOI:10.1016/j.clinsp.2024.100430