Pho81 is a novel regulator of pexophagy induced by phosphate starvation.

التفاصيل البيبلوغرافية
العنوان:	Pho81 is a novel regulator of pexophagy induced by phosphate starvation.
المؤلفون:	Huang Y; Life Sciences Institute and Department of Molecular, Cellular and Development Biology, University of Michigan, Ann Arbor, MI, USA., Klionsky DJ; Life Sciences Institute and Department of Molecular, Cellular and Development Biology, University of Michigan, Ann Arbor, MI, USA.
المصدر:	Autophagy [Autophagy] 2024 Jul 11, pp. 1-2. Date of Electronic Publication: 2024 Jul 11.
Publication Model:	Ahead of Print
نوع المنشور:	Editorial
اللغة:	English
بيانات الدورية:	Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101265188 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8635 (Electronic) Linking ISSN: 15548627 NLM ISO Abbreviation: Autophagy Subsets: MEDLINE
أسماء مطبوعة:	Publication: 2015- : Philadelphia, PA : Taylor & Francis Original Publication: Georgetown, TX : Landes Bioscience, 2005-
مستخلص:	In the budding yeast Saccharomyces cerevisiae , macroautophagy/autophagy can be induced by various types of starvation. It is thought that potential autophagic substrates vary to meet specific nutritional demands under different starvation conditions. In a recent study, Gross et al . found that autophagy induced by phosphate starvation includes many selective aspects. For example, this work identified Pho81 as a regulator of pexophagy under conditions of phosphate starvation. Pho81 senses phosphate metabolites and directly interacts with Atg11 to promote Atg1-mediated Atg11 phosphorylation. This finding provides an example of how modulation of the Atg1/ULK kinase complex can convey specific metabolic information to regulate autophagic substrates. Abbreviation : AKC: Atg1/ULK kinase complex.
فهرسة مساهمة:	Keywords: Atg11 phosphorylation; GFP-Atg8 processing assay; SPX domain; autophagy; proteomics
تواريخ الأحداث:	Date Created: 20240711 Latest Revision: 20240711
رمز التحديث:	20240712
DOI:	10.1080/15548627.2024.2377421
PMID:	38991544
قاعدة البيانات:	MEDLINE

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تدمد:	1554-8635
DOI:	10.1080/15548627.2024.2377421