Editorial & Opinion
Pho81 is a novel regulator of pexophagy induced by phosphate starvation.
العنوان: | Pho81 is a novel regulator of pexophagy induced by phosphate starvation. |
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المؤلفون: | Huang Y; Life Sciences Institute and Department of Molecular, Cellular and Development Biology, University of Michigan, Ann Arbor, MI, USA., Klionsky DJ; Life Sciences Institute and Department of Molecular, Cellular and Development Biology, University of Michigan, Ann Arbor, MI, USA. |
المصدر: | Autophagy [Autophagy] 2024 Jul 11, pp. 1-2. Date of Electronic Publication: 2024 Jul 11. |
Publication Model: | Ahead of Print |
نوع المنشور: | Editorial |
اللغة: | English |
بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101265188 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8635 (Electronic) Linking ISSN: 15548627 NLM ISO Abbreviation: Autophagy Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2015- : Philadelphia, PA : Taylor & Francis Original Publication: Georgetown, TX : Landes Bioscience, 2005- |
مستخلص: | In the budding yeast Saccharomyces cerevisiae , macroautophagy/autophagy can be induced by various types of starvation. It is thought that potential autophagic substrates vary to meet specific nutritional demands under different starvation conditions. In a recent study, Gross et al . found that autophagy induced by phosphate starvation includes many selective aspects. For example, this work identified Pho81 as a regulator of pexophagy under conditions of phosphate starvation. Pho81 senses phosphate metabolites and directly interacts with Atg11 to promote Atg1-mediated Atg11 phosphorylation. This finding provides an example of how modulation of the Atg1/ULK kinase complex can convey specific metabolic information to regulate autophagic substrates. Abbreviation : AKC: Atg1/ULK kinase complex. |
فهرسة مساهمة: | Keywords: Atg11 phosphorylation; GFP-Atg8 processing assay; SPX domain; autophagy; proteomics |
تواريخ الأحداث: | Date Created: 20240711 Latest Revision: 20240711 |
رمز التحديث: | 20240712 |
DOI: | 10.1080/15548627.2024.2377421 |
PMID: | 38991544 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1554-8635 |
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DOI: | 10.1080/15548627.2024.2377421 |