دورية أكاديمية
Spleen Volume Reduction Is a Reliable and Independent Biomarker for Long-Term Risk of Leukopenia Development in Peptide Receptor Radionuclide Therapy.
| العنوان: | Spleen Volume Reduction Is a Reliable and Independent Biomarker for Long-Term Risk of Leukopenia Development in Peptide Receptor Radionuclide Therapy. |
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| المؤلفون: | Steinhelfer L; Department of Radiology, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany; lisa.steinhelfer@tum.de rbraren@tum.de., Jungmann F; Department of Radiology, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany., Endrös L; Department of Radiology, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany., Wenzel P; Medical Clinic and Polyclinic II, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany., Haller B; Institute of AI and Informatics in Medicine, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany., Nickel M; Institute of AI and Informatics in Medicine, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany., Haneder E; Department of Radiology, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany., Geisler F; Medical Clinic and Polyclinic II, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany., Götze K; Medical Clinic and Polyclinic III, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany., von Werder A; Medical Clinic and Polyclinic II, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany., Eiber M; Department of Nuclear Medicine, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany; and.; German Cancer Consortium, a Partnership Between DKFZ and School of Medicine, Technical University of Munich, Munich, Germany., Makowski MR; Department of Radiology, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany., Braren R; Department of Radiology, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany; lisa.steinhelfer@tum.de rbraren@tum.de.; German Cancer Consortium, a Partnership Between DKFZ and School of Medicine, Technical University of Munich, Munich, Germany., Lohöfer F; Department of Radiology, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany. |
| المصدر: | Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 2024 Aug 01; Vol. 65 (8), pp. 1244-1249. Date of Electronic Publication: 2024 Aug 01. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Society of Nuclear Medicine Country of Publication: United States NLM ID: 0217410 Publication Model: Electronic Cited Medium: Internet ISSN: 1535-5667 (Electronic) Linking ISSN: 01615505 NLM ISO Abbreviation: J Nucl Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Reston, VA : Society of Nuclear Medicine Original Publication: [Chicago, Ill.] : S.N. Turiel & Assoc. |
| مواضيع طبية MeSH: | Leukopenia*/etiology , Spleen*/diagnostic imaging , Spleen*/radiation effects , Octreotide*/analogs & derivatives , Octreotide*/therapeutic use , Octreotide*/adverse effects , Neuroendocrine Tumors*/radiotherapy , Neuroendocrine Tumors*/diagnostic imaging , Receptors, Peptide*/metabolism , Organometallic Compounds*/adverse effects , Organometallic Compounds*/therapeutic use, Humans ; Female ; Male ; Middle Aged ; Retrospective Studies ; Aged ; Organ Size ; Adult ; Biomarkers ; Aged, 80 and over |
| مستخلص: | 177 Lu-DOTATATE therapy is an effective treatment for advanced neuroendocrine tumors, despite its dose-limiting hematotoxicity. Herein, the significance of off-target splenic irradiation is unknown. Our study aims to identify predictive markers of peptide receptor radionuclide therapy-induced leukopenia. Methods: We retrospectively analyzed blood counts and imaging data of 88 patients with histologically confirmed, unresectable metastatic neuroendocrine tumors who received 177 Lu-DOTATATE treatment at our institution from February 2009 to July 2021. Inclusion criterium was a tumor uptake equivalent to or greater than that in the liver on baseline receptor imaging. We excluded patients with less than 24 mo of follow-up and those patients who received fewer than 4 treatment cycles, additional therapies, or blood transfusions during follow-up. Results: Our study revealed absolute and relative white blood cell counts and relative spleen volume reduction as independent predictors of radiation-induced leukopenia at 24 mo. However, a 30% decline in spleen volume 12 mo after treatment most accurately predicted patients proceeding to leukopenia at 24 mo (receiver operating characteristic area under the curve of 0.91, sensitivity of 0.93, and specificity of 0.90), outperforming all other parameters by far. Conclusion: Automated splenic volume assessments demonstrated superior predictive capabilities for the development of leukopenia in patients undergoing 177 Lu-DOTATATE treatment compared with conventional laboratory parameters. The reduction in spleen size proves to be a valuable, routinely available, and quantitative imaging-based biomarker for predicting radiation-induced leukopenia. This suggests potential clinical applications for risk assessment and management. (© 2024 by the Society of Nuclear Medicine and Molecular Imaging.) |
| فهرسة مساهمة: | Keywords: 177Lu-DOTATATE; PRRT; imaging-based biomarker; leukopenia; spleen volumetry |
| المشرفين على المادة: | RWM8CCW8GP (Octreotide) AE221IM3BB (lutetium Lu 177 dotatate) 0 (Receptors, Peptide) 0 (Organometallic Compounds) 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20240711 Date Completed: 20240801 Latest Revision: 20240801 |
| رمز التحديث: | 20240802 |
| DOI: | 10.2967/jnumed.123.267098 |
| PMID: | 38991748 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1535-5667 |
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| DOI: | 10.2967/jnumed.123.267098 |