دورية أكاديمية
Factors Associated with Myocardial Uptake on Oncologic Somatostatin PET Investigations and Differentiation from Myocardial Uptake of Acute Myocarditis.
| العنوان: | Factors Associated with Myocardial Uptake on Oncologic Somatostatin PET Investigations and Differentiation from Myocardial Uptake of Acute Myocarditis. |
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| المؤلفون: | Larive T; Department of Nuclear Medicine, CHRU Nancy, Université de Lorraine, Nancy, France.; Nancyclotep Imaging Platform, CHRU Nancy, Université de Lorraine, Nancy, France., Boursier C; Department of Nuclear Medicine, CHRU Nancy, Université de Lorraine, Nancy, France.; Nancyclotep Imaging Platform, CHRU Nancy, Université de Lorraine, Nancy, France.; UMR 1254, INSERM, Université de Lorraine, Nancy, France., Claudin M; Department of Nuclear Medicine, CHRU Nancy, Université de Lorraine, Nancy, France.; Nancyclotep Imaging Platform, CHRU Nancy, Université de Lorraine, Nancy, France., Varlot J; Department of Cardiology, CHRU Nancy, Nancy, France., Filippetti L; Department of Cardiology, CHRU Nancy, Nancy, France., Huttin O; Department of Cardiology, CHRU Nancy, Nancy, France.; UMR 1116, INSERM, Université de Lorraine, Nancy, France., Roch V; Nancyclotep Imaging Platform, CHRU Nancy, Université de Lorraine, Nancy, France., Imbert L; Department of Nuclear Medicine, CHRU Nancy, Université de Lorraine, Nancy, France.; Nancyclotep Imaging Platform, CHRU Nancy, Université de Lorraine, Nancy, France.; UMR 1254, INSERM, Université de Lorraine, Nancy, France., Doyen M; UMR 1254, INSERM, Université de Lorraine, Nancy, France.; Université de Lorraine, Nancy, France., Lambert A; Department of Medical Oncology, Institut de Cancérologie de Lorraine, Vandœuvre-lès-Nancy, France., Mandry D; UMR 1254, INSERM, Université de Lorraine, Nancy, France.; Department of Radiology, CHRU Nancy, Université de Lorraine, Nancy, France., Lamiral Z; CIC 1433, INSERM, CHRU Nancy, Nancy, France., Chevalier E; Department of Nuclear Medicine, CHRU Nancy, Université de Lorraine, Nancy, France.; Nancyclotep Imaging Platform, CHRU Nancy, Université de Lorraine, Nancy, France., Marie PY; Department of Nuclear Medicine, CHRU Nancy, Université de Lorraine, Nancy, France; py.marie@chru-nancy.fr.; Nancyclotep Imaging Platform, CHRU Nancy, Université de Lorraine, Nancy, France.; UMR 1254, INSERM, Université de Lorraine, Nancy, France. |
| المصدر: | Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 2024 Aug 01; Vol. 65 (8), pp. 1279-1285. Date of Electronic Publication: 2024 Aug 01. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Society of Nuclear Medicine Country of Publication: United States NLM ID: 0217410 Publication Model: Electronic Cited Medium: Internet ISSN: 1535-5667 (Electronic) Linking ISSN: 01615505 NLM ISO Abbreviation: J Nucl Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Reston, VA : Society of Nuclear Medicine Original Publication: [Chicago, Ill.] : S.N. Turiel & Assoc. |
| مواضيع طبية MeSH: | Myocarditis*/diagnostic imaging , Myocarditis*/metabolism , Myocardium*/metabolism , Somatostatin*/analogs & derivatives , Somatostatin*/metabolism , Positron-Emission Tomography* , Octreotide*/analogs & derivatives , Octreotide*/metabolism , Octreotide*/pharmacokinetics, Humans ; Male ; Female ; Middle Aged ; Adult ; Acute Disease ; Diagnosis, Differential ; Aged ; Heart/diagnostic imaging ; Organometallic Compounds/pharmacokinetics ; Organometallic Compounds/metabolism ; Biological Transport ; Retrospective Studies ; Radiopharmaceuticals/pharmacokinetics ; Neoplasms/diagnostic imaging ; Neoplasms/metabolism |
| مستخلص: | Myocardial somatostatin PET uptake is observed not only in most patients with acute myocarditis (AM) but also in some oncology patients referred for routine somatostatin PET. This raises concerns about the specificity of somatostatin PET for detecting myocarditis. The current study aims to identify factors associated with the detection of myocardial uptake on somatostatin PET scans recorded for oncology indications and differential PET criteria that characterize myocardial uptake in AM patients. Methods: We analyzed factors associated with the detection of myocardial [ 68 Ga]Ga-DOTATOC uptake in 508 [ 68 Ga]Ga-DOTATOC PET scans from 178 patients, performed for confirmed or suspected oncologic disease (Onc-PET) and PET criteria that could differentiate myocardial [ 68 Ga]Ga-DOTATOC uptake in 31 patients with MRI-ascertained AM (AM-PET) from that in the Onc-PET group. Results: Significant myocardial uptake was detected in 137 (26.9%) Onc-PET scans and was independently associated with somatostatin analog treatment (exp(β), 0.805; 95% CI, 0.728-0.890; P < 0.001) and age (exp(β), 1.005; 95% CI, 1.001-1.009; P = 0.012). A comparable model was selected for predicting the myocardial-to-blood SUV (© 2024 by the Society of Nuclear Medicine and Molecular Imaging.) |
| فهرسة مساهمة: | Keywords: PET; [68Ga]Ga-DOTATOC; acute myocarditis; myocardial inflammation; somatostatin receptor |
| المشرفين على المادة: | 51110-01-1 (Somatostatin) RWM8CCW8GP (Octreotide) 0 (Ga(III)-DOTATOC) 0 (Organometallic Compounds) 0 (Radiopharmaceuticals) |
| تواريخ الأحداث: | Date Created: 20240711 Date Completed: 20240801 Latest Revision: 20240801 |
| رمز التحديث: | 20240802 |
| DOI: | 10.2967/jnumed.123.267219 |
| PMID: | 38991751 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1535-5667 |
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| DOI: | 10.2967/jnumed.123.267219 |