دورية أكاديمية
أعرض في EDS

Preparation, characterization and antioxidant and anticancerous potential of Quercetin loaded β-glucan particles derived from mushroom and yeast.

التفاصيل البيبلوغرافية
العنوان: Preparation, characterization and antioxidant and anticancerous potential of Quercetin loaded β-glucan particles derived from mushroom and yeast.
المؤلفون: Trivedi R; Department of Biotechnology, Parul Institute of Applied Sciences and Research and Development Cell, Parul University, Vadodara, Gujarat, 391760, India., Upadhyay TK; Department of Biotechnology, Parul Institute of Applied Sciences and Research and Development Cell, Parul University, Vadodara, Gujarat, 391760, India. tarun_bioinfo@yahoo.co.in.
المصدر: Scientific reports [Sci Rep] 2024 Jul 11; Vol. 14 (1), pp. 16047. Date of Electronic Publication: 2024 Jul 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Quercetin*/pharmacology , Quercetin*/chemistry , beta-Glucans*/pharmacology , beta-Glucans*/chemistry , Antioxidants*/pharmacology , Antioxidants*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Agaricus*/chemistry , Saccharomyces cerevisiae*/drug effects, Humans ; Cell Survival/drug effects ; PC-3 Cells ; Cell Line, Tumor ; Reactive Oxygen Species/metabolism
مستخلص: β-glucans are polysaccharides found in the cell walls of various fungi, bacteria and cereals. β-glucan have been found to show various kinds of anti-inflammatory, antimicrobial, antidiabetic antioxidant and anticancerous activities. In the present study, we have isolated β-glucan from the baker's yeast Saccharomyces cerevisiae and white button mushroom Agaricus bisporus and tested their antioxidant potential and anticancerous activity against prostate cancer cell line PC3. Particles were characterized with zeta sizer and further with FTIR that confirmed that the isolated particles are β-glucan and alginate sealing made slow and sustained release of the Quercetin from the β-glucan particles. Morphological analysis of the hollow and Quercetin loaded β-glucan was performed with the SEM analysis and stability was analyzed with TGA and DSC analysis that showed the higher stability of the alginate sealed particles. Assessments of the antioxidant potential showed that Quercetin loaded particles were having higher antioxidant activity than hollow β-glucan particles. Cell viability of the PC3 cells was examined with MTT assay and it was found that Quercetin loaded alginate sealed Agaricus bisporus derived β-glucan particles were having lowest IC50. Further ROS generation was found to increase in a dose dependent manner. Apoptosis detection was carried out with Propidium iodide and AO/EtBr staining dye which showed significant death in the cells treated with higher concentration of the particles. Study showed that particles derived from both of the sources were having efficient anticancer activity and showing a dose dependent increase in cell death in PC3 cells upon treatment.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Apoptosis; Cell migration; DNA fragmentation; Drug release; Hemolysis; Prostate cancer; Quercetin; β-glucan
المشرفين على المادة: 9IKM0I5T1E (Quercetin)
0 (beta-Glucans)
0 (Antioxidants)
0 (Antineoplastic Agents)
0 (Reactive Oxygen Species)
SCR Organism: Agaricus bisporus
تواريخ الأحداث: Date Created: 20240711 Date Completed: 20240711 Latest Revision: 20240731
رمز التحديث: 20240731
مُعرف محوري في PubMed: PMC11239821
DOI: 10.1038/s41598-024-66824-1
PMID: 38992105
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-024-66824-1