دورية أكاديمية
أعرض في EDS

Sodium tanshinone IIA sulfonate protects vascular relaxation in ApoE-knockout mice by inhibiting the SYK-NLRP3 inflammasome-MMP2/9 pathway.

التفاصيل البيبلوغرافية
العنوان: Sodium tanshinone IIA sulfonate protects vascular relaxation in ApoE-knockout mice by inhibiting the SYK-NLRP3 inflammasome-MMP2/9 pathway.
المؤلفون: Liu HH; Department of Endocrinology, Heping Hospital Affiliated to Changzhi Medical College, No.110, Yan'an South Road, Changzhi, 046000, Shanxi, China., Wei W; Department of Endocrinology, Heping Hospital Affiliated to Changzhi Medical College, No.110, Yan'an South Road, Changzhi, 046000, Shanxi, China. jaywei@czmc.edu.cn.; Department of Pharmacology, Changzhi Medical College, No.161, Jiefang East Street, Changzhi, 046000, Shanxi, China. jaywei@czmc.edu.cn.; Department of Clinical Center Laboratory, Heping Hospital Affiliated to Changzhi Medical College, No.110, Yan'an South Road, Changzhi, 046000, Shanxi, China. jaywei@czmc.edu.cn., Wu FF; Department of Endocrinology, Heping Hospital Affiliated to Changzhi Medical College, No.110, Yan'an South Road, Changzhi, 046000, Shanxi, China., Cao L; Department of Endocrinology, Heping Hospital Affiliated to Changzhi Medical College, No.110, Yan'an South Road, Changzhi, 046000, Shanxi, China., Yang BJ; Department of Stomatology, Changzhi Medical College, No.161, Jiefang East Street, Changzhi, 046000, Shanxi, China., Fu JN; Department of Stomatology, Changzhi Medical College, No.161, Jiefang East Street, Changzhi, 046000, Shanxi, China., Li JX; Department of Anesthesia, Changzhi Medical College, No.161, Jiefang East Street, Changzhi, 046000, Shanxi, China., Liang XY; Department of Medical Imageology, Changzhi Medical College, No.161, Jiefang East Street, Changzhi, 046000, Shanxi, China., Dong HY; Department of Endocrinology, Heping Hospital Affiliated to Changzhi Medical College, No.110, Yan'an South Road, Changzhi, 046000, Shanxi, China., Heng YY; Department of Nephrology Heping Hospital, Changzhi Medical College, No.110, Yanan Road South, Changzhi, 046000, Shanxi, China., Zhang PF; Department of Nephrology Heping Hospital, Changzhi Medical College, No.110, Yanan Road South, Changzhi, 046000, Shanxi, China.
المصدر: BMC cardiovascular disorders [BMC Cardiovasc Disord] 2024 Jul 12; Vol. 24 (1), pp. 354. Date of Electronic Publication: 2024 Jul 12.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968539 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2261 (Electronic) Linking ISSN: 14712261 NLM ISO Abbreviation: BMC Cardiovasc Disord Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , Inflammasomes*/metabolism , Syk Kinase*/metabolism , Signal Transduction* , Mice, Knockout, ApoE* , Disease Models, Animal* , Matrix Metalloproteinase 2*/metabolism , Phenanthrenes*/pharmacology , Matrix Metalloproteinase 9*/metabolism , Mice, Inbred C57BL* , Vasodilation*/drug effects, Animals ; Male ; Hyperlipidemias/drug therapy ; Hyperlipidemias/physiopathology ; Vasodilator Agents/pharmacology ; Phosphorylation ; Mice ; Aorta/drug effects ; Aorta/physiopathology ; Aorta/metabolism ; Aorta/enzymology ; Apolipoproteins E
مستخلص: Background: Hyperlipidemia damages vascular wall and serves as a foundation for diseases such as atherosclerosis, hypertension and stiffness. The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is implicated in vascular dysfunction associated with hyperlipidemia-induced vascular injury. Sodium tanshinone IIA sulfonate (STS), a well-established cardiovascular protective drug with recognized anti-inflammatory, antioxidant, and vasodilatory properties, is yet to be thoroughly investigated for its impact on vascular relaxant imbalance induced by hyperlipidemia.
Methods: In this study, we treated ApoE-knockout (ApoE-/-) mouse with STS and assessed the activation of the NLRP3 inflammasome, expression of MMP2/9, integrity of elastic fibers, and vascular constriction and relaxation.
Results: Our findings reveal that STS intervention effectively preserves elastic fibers, significantly restores aortic relaxation function in ApoE-/- mice, and reduces their excessive constriction. Furthermore, STS inhibits the phosphorylation of spleen tyrosine kinase (SYK), suppresses NLRP3 inflammasome activation, and reduces MMP2/9 expression.
Conclusions: These results demonstrate that STS protects vascular relaxation against hyperlipidemia-induced damage through modulation of the SYK-NLRP3 inflammasome-MMP2/9 pathway. This research provides novel insights into the mechanisms underlying vascular relaxation impairment in a hyperlipidemic environment and uncovers a unique mechanism by which STS preserves vascular relaxation, offering valuable foundational research evidence for its clinical application in promoting vascular health.
(© 2024. The Author(s).)
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معلومات مُعتمدة: HPYJ202210 Heping Hospital Affiliated to Changzhi Medical College, China; HPYJ202218 Heping Hospital Affiliated to Changzhi Medical College, China; HPYJ201921 Heping Hospital Affiliated to Changzhi Medical College, China; 2021L351 Education department of Shanxi, China; BS202115 Changzhi Medical College, China; 202203021211107 Department of Science and Technology of Shanxi; 2022021 Health Commission of Shanxi Province
فهرسة مساهمة: Keywords: Hyperlipidemia; MMP2/9; NLRP3 inflammasome; Sodium tanshinone IIA sulfonate; Vascular relaxation
المشرفين على المادة: 0 (NLR Family, Pyrin Domain-Containing 3 Protein)
0 (Nlrp3 protein, mouse)
69659-80-9 (tanshinone II A sodium sulfonate)
0 (Inflammasomes)
EC 2.7.10.2 (Syk Kinase)
EC 2.7.10.2 (Syk protein, mouse)
EC 3.4.24.24 (Mmp2 protein, mouse)
EC 3.4.24.24 (Matrix Metalloproteinase 2)
EC 3.4.24.35 (Mmp9 protein, mouse)
0 (Phenanthrenes)
EC 3.4.24.35 (Matrix Metalloproteinase 9)
0 (Vasodilator Agents)
0 (Apoe protein, mouse)
0 (Apolipoproteins E)
تواريخ الأحداث: Date Created: 20240711 Date Completed: 20240712 Latest Revision: 20240714
رمز التحديث: 20240714
مُعرف محوري في PubMed: PMC11241843
DOI: 10.1186/s12872-024-03990-0
PMID: 38992615
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2261
DOI:10.1186/s12872-024-03990-0