دورية أكاديمية
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Medium-chain triglycerides combined with DHA improve cognitive function by inhibiting neurocyte apoptosis of the brain in SAMP8 mice.

التفاصيل البيبلوغرافية
العنوان: Medium-chain triglycerides combined with DHA improve cognitive function by inhibiting neurocyte apoptosis of the brain in SAMP8 mice.
المؤلفون: Sun Y; Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China., Zhou D; School of Public Health, Health Science Center, Ningbo University, Zhejiang Key Laboratory of Pathophysiology, Ningbo, Zhejiang 315211, China., Wang Y; Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China., Wang Z; Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China., Zhang D; Department of Toxicology, Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China., Qian Z; Department of Toxicology, Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China., Yan J; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070, China; Department of Social Medicine and Health Administration, School of Public Health, Tianjin Medical University, Tianjin 300070, China., Li Z; Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070, China., Huang G; Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070, China., Li W; Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070, China. Electronic address: liwen828@tmu.edu.cn.
المصدر: Experimental gerontology [Exp Gerontol] 2024 Sep; Vol. 194, pp. 112520. Date of Electronic Publication: 2024 Jul 10.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 0047061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6815 (Electronic) Linking ISSN: 05315565 NLM ISO Abbreviation: Exp Gerontol Subsets: MEDLINE
أسماء مطبوعة: Publication: Tarrytown Ny : Elsevier Science
Original Publication: Oxford.
مواضيع طبية MeSH: Docosahexaenoic Acids*/pharmacology , Apoptosis*/drug effects , Cognition*/drug effects , Triglycerides* , Brain*/drug effects , Brain*/pathology, Animals ; Male ; Mice ; Maze Learning/drug effects ; Dietary Supplements ; Aging ; Morris Water Maze Test/drug effects ; Neurons/drug effects ; Caprylates/pharmacology ; Disease Models, Animal
مستخلص: Medium-chain triglycerides (MCTs) and docosahexaenoic acid (DHA, C n-3, 22:6 ) are essential in improving cognitive function and protecting neurocytes. This study explored the effects of the combined intervention of MCTs and DHA on inhibiting neurocyte apoptosis of the brain and improving cognitive function in senescence-accelerated mouse-prone 8 (SAMP8). Four-month-old male SAMP8 mice were randomly divided into four treatment groups (12 mice/group): DHA, MCT, DHA + MCT, and control groups, which intervened for seven months. Twelve age-matched male senescence-accelerated mouse resistant 1 (SAMR1) was used as the natural aging group. TUNEL assay and HE staining were used to assess neurocyte apoptosis and damage in the brain of mice. Moreover, the cognitive function was analyzed using the Morris water maze (MWM) and open field (OF) tests. The results showed that the cognitive function of 11-month-old SAMP8 mice decreased with age, and further pathological examination revealed the damaged neurocyte structure, karyopyknosis, cell atrophy, and even apoptosis. MCTs combined with DHA supplementation could increase octanoic acid (C8:0), decanoic acid (C10:0), and DHA levels in the serum, inhibit neurocyte apoptosis, improve neurocyte damage, moreover delay age-related cognitive decline after seven-month treatment. Furthermore, combining MCTs and DHA was significantly more beneficial than MCTs or DHA alone. In conclusion, MCTs combined with DHA could delay cognitive decline by inhibiting neurocyte apoptosis of the brain in SAMP8 mice.
Competing Interests: Declaration of competing interest The authors declare that they have no conflicts of interest.
(Copyright © 2024. Published by Elsevier Inc.)
فهرسة مساهمة: Keywords: Apoptosis; Cognitive function; Docosahexaenoic acid; Medium-chain triglycerides; Mouse; Neurocyte
المشرفين على المادة: 25167-62-8 (Docosahexaenoic Acids)
0 (Triglycerides)
0 (Caprylates)
OBL58JN025 (octanoic acid)
تواريخ الأحداث: Date Created: 20240711 Date Completed: 20240728 Latest Revision: 20240728
رمز التحديث: 20240728
DOI: 10.1016/j.exger.2024.112520
PMID: 38992823
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-6815
DOI:10.1016/j.exger.2024.112520