دورية أكاديمية
Right ventricular diastolic adaptation to pressure overload in different rat strains.
| العنوان: | Right ventricular diastolic adaptation to pressure overload in different rat strains. |
|---|---|
| المؤلفون: | Axelsen JS; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Andersen S; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Ringgaard S; MR Research Center, Aarhus University, Aarhus, Denmark., Smal R; Department of Pulmonary Medicine, PHEniX Laboratory, Amsterdam UMC, Locatie VUmc, Amsterdam, The Netherlands., Lluciá-Valldeperas A; Department of Pulmonary Medicine, PHEniX Laboratory, Amsterdam UMC, Locatie VUmc, Amsterdam, The Netherlands., Nielsen-Kudsk JE; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., de Man FS; Department of Pulmonary Medicine, PHEniX Laboratory, Amsterdam UMC, Locatie VUmc, Amsterdam, The Netherlands., Andersen A; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. |
| المصدر: | Physiological reports [Physiol Rep] 2024 Jul; Vol. 12 (13), pp. e16132. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society Country of Publication: United States NLM ID: 101607800 Publication Model: Print Cited Medium: Internet ISSN: 2051-817X (Electronic) Linking ISSN: 2051817X NLM ISO Abbreviation: Physiol Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Malden MA] : published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society, 2013- |
| مواضيع طبية MeSH: | Diastole*/physiology , Ventricular Function, Right*/physiology , Adaptation, Physiological*/physiology , Rats, Sprague-Dawley* , Rats, Wistar*, Animals ; Male ; Rats ; Ventricular Dysfunction, Right/physiopathology ; Ventricular Dysfunction, Right/diagnostic imaging ; Rats, Inbred F344 ; Hypertension, Pulmonary/physiopathology ; Hypertension, Pulmonary/etiology ; Heart Ventricles/physiopathology ; Heart Ventricles/diagnostic imaging ; Species Specificity |
| مستخلص: | Different rat strains are used in various animal models of pulmonary hypertension and right ventricular (RV) failure. No systematic assessment has been made to test differences in RV response to pressure overload between rat strains. We compared RV adaptation to pulmonary trunk banding (PTB) in Wistar (W), Sprague Dawley (SD), and Fischer344 (F) rats by hemodynamic profiling focusing on diastolic function. Age-matched male rat weanlings were randomized to sham surgery (W-sham, n = 5; SD-sham, n = 4; F-sham, n = 4) or PTB (W-PTB, n = 8; SD-PTB, n = 8; F-PTB, n = 8). RV function was evaluated after 5 weeks by echocardiography, cardiac MRI, and invasive pressure-volume measurements. PTB caused RV failure and increased RV systolic pressures four-fold in all three PTB groups compared with sham. W- and SD-PTB had a 2.4-fold increase in RV end-systolic volume index compared with sham, while F-PTB rats were less affected. Diastolic and right atrial impairment were evident by increased RV end-diastolic elastance, filling pressure, and E/e' in PTB rats compared with sham, again F-PTB the least affected. In conclusions, PTB caused RV failure with signs of diastolic dysfunction. Despite a similar increase in RV systolic pressure, F-PTB rats showed less RV dilatation and a more preserved diastolic function compared with W- and SD-PTB. (© 2024 The Author(s). Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.) |
| References: | J Heart Lung Transplant. 2014 Apr;33(4):382-7. (PMID: 24534251) Am J Physiol Heart Circ Physiol. 2021 Oct 1;321(4):H702-H715. (PMID: 34448637) Am J Physiol Heart Circ Physiol. 2020 Jan 1;318(1):H156-H164. (PMID: 31756118) Heart Fail Rev. 2015 May;20(3):363-73. (PMID: 25633340) Toxicology. 1993 Mar 30;79(1):21-35. (PMID: 8475497) Lab Anim. 2012 Jan;46(1):40-5. (PMID: 22008848) Inhal Toxicol. 2015;27 Suppl 1:63-79. (PMID: 26667332) J Vis Exp. 2018 Nov 29;(141):. (PMID: 30582605) Int J Cardiovasc Imaging. 2020 Apr;36(4):633-642. (PMID: 31912453) Am J Respir Cell Mol Biol. 2016 Apr;54(4):461-8. (PMID: 26291195) Circulation. 2005 Aug 30;112(9 Suppl):I212-8. (PMID: 16159819) Biostat Bioinforma Biomath. 2013 Aug;3(3):71-85. (PMID: 25558171) J Mol Cell Cardiol. 1991 Oct;23(10):1177-90. (PMID: 1836237) BMC Med Imaging. 2010 Jan 11;10:1. (PMID: 20064248) Cardiovasc Res. 2019 Mar 15;115(4):788-799. (PMID: 30357319) J Am Coll Cardiol. 2002 Apr 3;39(7):1214-9. (PMID: 11923049) J Am Coll Cardiol. 2023 Aug 22;82(8):704-717. (PMID: 37587582) Hypertension. 2022 Dec;79(12):2774-2786. (PMID: 36278405) Chest. 2022 Apr;161(4):1048-1059. (PMID: 34637777) Circulation. 2013 Oct 29;128(18):2016-25, 1-10. (PMID: 24056688) Pulm Circ. 2020 May 26;10(2):2045894020908787. (PMID: 32518619) Br J Pharmacol. 2022 Mar;179(5):811-837. (PMID: 33724447) Clin Exp Hypertens. 2000 Jul;22(5):471-92. (PMID: 10937839) Int J Cardiol. 2009 Jun 12;135(1):53-9. (PMID: 18793807) J Am Heart Assoc. 2019 Mar 5;8(5):e011227. (PMID: 30807241) Biomed Res Int. 2015;2015:753210. (PMID: 26504827) Resuscitation. 2002 May;53(2):189-200. (PMID: 12009223) J Mol Cell Cardiol. 2018 Jan;114:20-28. (PMID: 29055654) Am J Physiol Heart Circ Physiol. 2020 May 1;318(5):H1139-H1158. (PMID: 32216614) Biomedicines. 2020 Oct 19;8(10):. (PMID: 33086482) J Am Coll Cardiol. 2013 Dec 24;62(25 Suppl):D22-33. (PMID: 24355638) Physiol Rep. 2024 Jul;12(13):e16132. (PMID: 38993022) Heart Fail Rev. 2015 Jul;20(4):475-91. (PMID: 25771982) Am J Physiol Heart Circ Physiol. 2016 Oct 1;311(4):H1004-H1013. (PMID: 27473939) Am J Physiol Heart Circ Physiol. 2018 Sep 1;315(3):H699-H708. (PMID: 29882684) ILAR J. 2014;55(3):399-404. (PMID: 25541542) Eur Respir J. 2022 Jun 23;59(6):. (PMID: 34764180) Circulation. 2008 Apr 1;117(13):1717-31. (PMID: 18378625) Eur Heart J Cardiovasc Imaging. 2022 Jun 21;23(7):867-884. (PMID: 35079782) Eur Respir J. 1999 Jul;14(1):125-31. (PMID: 10489839) Exp Physiol. 2017 Feb 1;102(2):180-189. (PMID: 27990701) Inhal Toxicol. 2015;27 Suppl 1:26-38. (PMID: 26667329) BMJ Open. 2020 Sep 22;10(9):e031316. (PMID: 32963060) Physiol Rep. 2021 Apr;9(7):e14810. (PMID: 33818005) Cardiovasc Diagn Ther. 2020 Oct;10(5):1659-1674. (PMID: 33224779) Heart Fail Rev. 2022 Jul;27(4):1077-1090. (PMID: 34013436) ERJ Open Res. 2023 Sep 18;9(5):. (PMID: 37727674) Cardiovasc Drugs Ther. 2024 Feb;38(1):57-68. (PMID: 36173474) |
| معلومات مُعتمدة: | 20-R140-A9671-22167 Hjerteforeningen (Heart Foundation); 2017-1064/96 The Danish Medical Research Grant; 20-L-0184 A.P. Moeller Fonden; DC472123-004-lek Helga og Peter Kornings Fond (Helga and Peter Korning's Fund); 25/11-2021 Soester og Verner Lipperts Fond; J167/1 Snedkermester Sophus Jacobsen og Hustru Astrid Jacobsens Fond; CVON-2018-29 The Netherlands Cardiovascular Research Initiative; CVON-2017-10 The Netherlands Cardiovascular Research Initiative; NWO-VIDI: 917.18.338 The Netherlands organization for scientific research; 2018t059 The Dutch Heart Foundation dekker senior postdoc grant |
| فهرسة مساهمة: | Keywords: diastolic dysfunction; pulmonary trunk banding; rat strains; right ventricular failure |
| تواريخ الأحداث: | Date Created: 20240712 Date Completed: 20240712 Latest Revision: 20240714 |
| رمز التحديث: | 20240714 |
| مُعرف محوري في PubMed: | PMC11239975 |
| DOI: | 10.14814/phy2.16132 |
| PMID: | 38993022 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2051-817X |
|---|---|
| DOI: | 10.14814/phy2.16132 |