دورية أكاديمية
Right ventricular diastolic adaptation to pressure overload in different rat strains.
العنوان: | Right ventricular diastolic adaptation to pressure overload in different rat strains. |
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المؤلفون: | Axelsen JS; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Andersen S; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Ringgaard S; MR Research Center, Aarhus University, Aarhus, Denmark., Smal R; Department of Pulmonary Medicine, PHEniX Laboratory, Amsterdam UMC, Locatie VUmc, Amsterdam, The Netherlands., Lluciá-Valldeperas A; Department of Pulmonary Medicine, PHEniX Laboratory, Amsterdam UMC, Locatie VUmc, Amsterdam, The Netherlands., Nielsen-Kudsk JE; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., de Man FS; Department of Pulmonary Medicine, PHEniX Laboratory, Amsterdam UMC, Locatie VUmc, Amsterdam, The Netherlands., Andersen A; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. |
المصدر: | Physiological reports [Physiol Rep] 2024 Jul; Vol. 12 (13), pp. e16132. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society Country of Publication: United States NLM ID: 101607800 Publication Model: Print Cited Medium: Internet ISSN: 2051-817X (Electronic) Linking ISSN: 2051817X NLM ISO Abbreviation: Physiol Rep Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [Malden MA] : published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society, 2013- |
مواضيع طبية MeSH: | Diastole*/physiology , Ventricular Function, Right*/physiology , Adaptation, Physiological*/physiology , Rats, Sprague-Dawley* , Rats, Wistar*, Animals ; Male ; Rats ; Ventricular Dysfunction, Right/physiopathology ; Ventricular Dysfunction, Right/diagnostic imaging ; Rats, Inbred F344 ; Hypertension, Pulmonary/physiopathology ; Hypertension, Pulmonary/etiology ; Heart Ventricles/physiopathology ; Heart Ventricles/diagnostic imaging ; Species Specificity |
مستخلص: | Different rat strains are used in various animal models of pulmonary hypertension and right ventricular (RV) failure. No systematic assessment has been made to test differences in RV response to pressure overload between rat strains. We compared RV adaptation to pulmonary trunk banding (PTB) in Wistar (W), Sprague Dawley (SD), and Fischer344 (F) rats by hemodynamic profiling focusing on diastolic function. Age-matched male rat weanlings were randomized to sham surgery (W-sham, n = 5; SD-sham, n = 4; F-sham, n = 4) or PTB (W-PTB, n = 8; SD-PTB, n = 8; F-PTB, n = 8). RV function was evaluated after 5 weeks by echocardiography, cardiac MRI, and invasive pressure-volume measurements. PTB caused RV failure and increased RV systolic pressures four-fold in all three PTB groups compared with sham. W- and SD-PTB had a 2.4-fold increase in RV end-systolic volume index compared with sham, while F-PTB rats were less affected. Diastolic and right atrial impairment were evident by increased RV end-diastolic elastance, filling pressure, and E/e' in PTB rats compared with sham, again F-PTB the least affected. In conclusions, PTB caused RV failure with signs of diastolic dysfunction. Despite a similar increase in RV systolic pressure, F-PTB rats showed less RV dilatation and a more preserved diastolic function compared with W- and SD-PTB. (© 2024 The Author(s). Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.) |
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معلومات مُعتمدة: | 20-R140-A9671-22167 Hjerteforeningen (Heart Foundation); 2017-1064/96 The Danish Medical Research Grant; 20-L-0184 A.P. Moeller Fonden; DC472123-004-lek Helga og Peter Kornings Fond (Helga and Peter Korning's Fund); 25/11-2021 Soester og Verner Lipperts Fond; J167/1 Snedkermester Sophus Jacobsen og Hustru Astrid Jacobsens Fond; CVON-2018-29 The Netherlands Cardiovascular Research Initiative; CVON-2017-10 The Netherlands Cardiovascular Research Initiative; NWO-VIDI: 917.18.338 The Netherlands organization for scientific research; 2018t059 The Dutch Heart Foundation dekker senior postdoc grant |
فهرسة مساهمة: | Keywords: diastolic dysfunction; pulmonary trunk banding; rat strains; right ventricular failure |
تواريخ الأحداث: | Date Created: 20240712 Date Completed: 20240712 Latest Revision: 20240714 |
رمز التحديث: | 20240714 |
مُعرف محوري في PubMed: | PMC11239975 |
DOI: | 10.14814/phy2.16132 |
PMID: | 38993022 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2051-817X |
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DOI: | 10.14814/phy2.16132 |