دورية أكاديمية
أعرض في EDS

Potential for organ donation after controlled circulatory death: a retrospective analysis.

التفاصيل البيبلوغرافية
العنوان: Potential for organ donation after controlled circulatory death: a retrospective analysis.
المؤلفون: Dias FS; Department of Intensive Care Medicine, Centro Hospitalar Universitário de São João, Porto, Portugal.; Department of Surgery and Physiology, Faculdade de Medicina da Universidade do Porto, Porto, Portugal., Fernandes DM; Department of Intensive Care Medicine, Centro Hospitalar Universitário de São João, Porto, Portugal., Cardoso-Fernandes A; Department of Community Medicine, Information and Health Decision Sciences (MEDCIDS), Faculdade de Medicina da Universidade do Porto, Porto, Portugal.; Center for Research in Health Technology and Services, Rede de Investigação em Saúde (CINTESIS@RISE), Faculdade de Medicina da Universidade do Porto, Porto, Portugal.; Department of Internal Medicine, Hospital de Santa Luzia, Unidade Local de Saúde do Alto Minho, Viana do Castelo, Portugal., Silva A; Department of Intensive Care Medicine, Centro Hospitalar Tâmega e Sousa, Penafiel, Portugal., Basílio C; Department of Intensive Care Medicine, Centro Hospitalar Universitário de São João, Porto, Portugal.; Department of Medicine, Faculdade de Medicina da Universidade do Porto, Porto, Portugal., Gatta N; Department of Intensive Care Medicine, Centro Hospitalar Universitário de São João, Porto, Portugal., Roncon-Albuquerque R Jr; Department of Intensive Care Medicine, Centro Hospitalar Universitário de São João, Porto, Portugal.; Department of Surgery and Physiology, Faculdade de Medicina da Universidade do Porto, Porto, Portugal., Paiva JA; Department of Intensive Care Medicine, Centro Hospitalar Universitário de São João, Porto, Portugal.; Department of Medicine, Faculdade de Medicina da Universidade do Porto, Porto, Portugal.
المصدر: Porto biomedical journal [Porto Biomed J] 2024 Jul 11; Vol. 9 (4), pp. 259. Date of Electronic Publication: 2024 Jul 11 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wolters Kluwer Country of Publication: United States NLM ID: 101707479 Publication Model: eCollection Cited Medium: Internet ISSN: 2444-8672 (Electronic) Linking ISSN: 24448664 NLM ISO Abbreviation: Porto Biomed J Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2018- : [Philadelphia, PA] : Wolters Kluwer
Original Publication: [Barcelona] : Elsevier España, S.L.U., [2016]-[2017]
مستخلص: Objectives: Despite the discrepancy between demand and availability of organs for transplantation, controlled circulatory death donation has not been implemented in Portugal. This study aimed to estimate the potential increase in organ donation from implementing such a program.
Material and Methods: All deceased patients within the intensive care medicine department at Centro Hospitalar Universitário de São João, throughout the year 2019, were subjected to retrospective analysis. Potential gain was estimated comparing the results with the number of donors and organs collected during the same period at this hospital center. Differences in variables between groups were assessed using t tests for independent samples or Mann-Whitney U tests for continuous variables, and chi-squared tests were used for categorical variables.
Results: During 2019, 152 deaths occurred after withdrawal of life-sustaining therapies, 10 of which would have been potentially eligible for donation after controlled circulatory death. We can anticipate a potential increase of 10 prospective donors, a maximum 21% growth in yearly transplantation activity, with a greater impact on kidney transplantation. For most patients, the time between withdrawal of organ support and death surpassed 120 minutes, an outcome explained by variations in withdrawal of life-sustaining measures and insufficient clinical records, underestimating the potential for controlled circulatory arrest donation.
Conclusion: This study effectively highlights public health benefits of controlled circulatory arrest donation. Legislation allowing donation through this method represents a social gain and enables patients who will never meet brain death criteria to donate organs as part of the end-of-life process in intensive care medicine, within a framework of complete ethical alignment.
Competing Interests: None of the authors has any funding or conflicts of interest to declare.
(Copyright © 2024 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of PBJ-Associação Porto Biomedical/Porto Biomedical Society.)
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فهرسة مساهمة: Keywords: chronic kidney disease; intensive care medicine; kidney transplantation; liver transplantation; organ procurement; treatment withdrawal
تواريخ الأحداث: Date Created: 20240712 Latest Revision: 20240714
رمز التحديث: 20240714
مُعرف محوري في PubMed: PMC11236395
DOI: 10.1097/j.pbj.0000000000000259
PMID: 38993948
قاعدة البيانات: MEDLINE
الوصف
تدمد:2444-8672
DOI:10.1097/j.pbj.0000000000000259