دورية أكاديمية
أعرض في EDS

Association between blood urea nitrogen to serum albumin ratio and in-hospital mortality in critical patients with diabetic ketoacidosis: a retrospective analysis of the eICU database.

التفاصيل البيبلوغرافية
العنوان: Association between blood urea nitrogen to serum albumin ratio and in-hospital mortality in critical patients with diabetic ketoacidosis: a retrospective analysis of the eICU database.
المؤلفون: Chen H; Center of Cardiovascular Medicine, Inner Mongolia People's Hospital, Hohhot, China.; Graduate School, Inner Mongolia Medical University, Hohhot, China., Wang Y; Center of Cardiovascular Medicine, Inner Mongolia People's Hospital, Hohhot, China.; Graduate School, Inner Mongolia Medical University, Hohhot, China., Ji R; Center of Cardiovascular Medicine, Inner Mongolia People's Hospital, Hohhot, China.; Graduate School, Inner Mongolia Medical University, Hohhot, China., Li M; Center of Cardiovascular Medicine, Inner Mongolia People's Hospital, Hohhot, China.; State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
المصدر: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2024 Jun 27; Vol. 15, pp. 1411891. Date of Electronic Publication: 2024 Jun 27 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Lausanne : Frontiers Research Foundation]
مواضيع طبية MeSH: Diabetic Ketoacidosis*/mortality , Diabetic Ketoacidosis*/blood , Hospital Mortality* , Blood Urea Nitrogen*, Humans ; Male ; Female ; Retrospective Studies ; Middle Aged ; Adult ; Serum Albumin/analysis ; Serum Albumin/metabolism ; Databases, Factual ; Aged ; Critical Illness/mortality
مستخلص: Background: This study aimed to investigate the association between blood urea nitrogen to serum albumin ratio (BAR) and the risk of in-hospital mortality in patients with diabetic ketoacidosis.
Methods: A total of 3,962 diabetic ketoacidosis patients from the eICU Collaborative Research Database were included in this analysis. The primary outcome was in-hospital death.
Results: Over a median length of hospital stay of 3.1 days, 86 in-hospital deaths were identified. One unit increase in LnBAR was positively associated with the risk of in-hospital death (hazard ratio [HR], 1.82 [95% CI, 1.42-2.34]). Furthermore, a nonlinear, consistently increasing correlation between elevated BAR and in-hospital mortality was observed (P for trend =0.005 after multiple-adjusted). When BAR was categorized into quartiles, the higher risk of in-hospital death (multiple-adjusted HR, 1.99 [95% CI, (1.1-3.6)]) was found in participants in quartiles 3 to 4 (BAR≥6.28) compared with those in quartiles 1 to 2 (BAR<6.28). In the subgroup analysis, the LnBAR-hospital death association was significantly stronger in participants without kidney insufficiency (yes versus no, P-interaction=0.023).
Conclusion: There was a significant and positive association between BAR and the risk of in-hospital death in patients with diabetic ketoacidosis. Notably, the strength of this association was intensified among those without kidney insufficiency.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2024 Chen, Wang, Ji and Li.)
References: Circulation. 2000 Jun 13;101(23):E215-20. (PMID: 10851218)
Diabetes Care. 2020 Feb;43(2):349-357. (PMID: 31704689)
JAMA. 2015 Nov 10;314(18):1966-7. (PMID: 26547468)
BMC Nephrol. 2019 Apr 2;20(1):115. (PMID: 30940101)
Diabetes Res Clin Pract. 2023 Mar;197:110555. (PMID: 36738833)
Endocrine. 2016 Jan;51(1):72-82. (PMID: 26115971)
Exp Clin Endocrinol Diabetes. 2024 May;132(5):249-259. (PMID: 38387890)
Pediatr Nephrol. 2023 Jul;38(7):2023-2031. (PMID: 36705755)
Open Life Sci. 2021 Dec 31;16(1):1365-1376. (PMID: 35071771)
J Clin Med. 2019 May 31;8(6):. (PMID: 31159248)
J Intern Med. 2000 Dec;248(6):511-7. (PMID: 11155144)
Transl Res. 2012 Apr;159(4):277-89. (PMID: 22424431)
JAMA Pediatr. 2017 May 1;171(5):e170020. (PMID: 28288246)
JAMA. 2017 Jan 17;317(3):280-289. (PMID: 28114552)
BMC Anesthesiol. 2022 Dec 28;22(1):404. (PMID: 36577937)
Cureus. 2022 May 27;14(5):e25410. (PMID: 35769689)
Sci Data. 2018 Sep 11;5:180178. (PMID: 30204154)
Diabetes Care. 2015 May;38(5):746-51. (PMID: 25665811)
J Emerg Med. 2020 Sep;59(3):371-383. (PMID: 32763063)
BMC Pulm Med. 2022 Dec 15;22(1):476. (PMID: 36522751)
Endocrinol Metab (Seoul). 2016 Sep;31(3):424-432. (PMID: 27586452)
Nat Rev Endocrinol. 2016 Apr;12(4):222-32. (PMID: 26893262)
Diabetes Metab. 2012 Apr;38(2):171-8. (PMID: 22349032)
BMJ. 2019 May 29;365:l1114. (PMID: 31142480)
Indian J Crit Care Med. 2018 Oct;22(10):733-736. (PMID: 30405285)
Am J Emerg Med. 2001 Jul;19(4):270-3. (PMID: 11447509)
Ann Emerg Med. 2023 Aug;82(2):167-178. (PMID: 37024382)
Am J Public Health. 1989 Mar;79(3):340-9. (PMID: 2916724)
BMJ Open. 2023 Aug 22;13(8):e069503. (PMID: 37607799)
J Eat Disord. 2023 Feb 20;11(1):26. (PMID: 36803805)
Front Public Health. 2023 Apr 06;11:1087297. (PMID: 37089510)
PLoS One. 2020 Oct 7;15(10):e0239160. (PMID: 33027293)
J Diabetes Res. 2016;2016:1269706. (PMID: 27504458)
Intensive Care Med. 2019 Dec;45(12):1718-1731. (PMID: 31531715)
Oman Med J. 2021 Mar 31;36(2):e241. (PMID: 33936777)
Endocrinol Metab (Seoul). 2013 Mar;28(1):26-32. (PMID: 24396647)
J Diabetes Res. 2013;2013:967097. (PMID: 24282823)
فهرسة مساهمة: Keywords: blood urea nitrogen to serum albumin ratio; diabetic ketoacidosis; eICU database; in-hospital mortality; intensive care unit
المشرفين على المادة: 0 (Serum Albumin)
تواريخ الأحداث: Date Created: 20240712 Date Completed: 20240712 Latest Revision: 20240714
رمز التحديث: 20240714
مُعرف محوري في PubMed: PMC11236567
DOI: 10.3389/fendo.2024.1411891
PMID: 38994011
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-2392
DOI:10.3389/fendo.2024.1411891