دورية أكاديمية
Association between blood urea nitrogen to serum albumin ratio and in-hospital mortality in critical patients with diabetic ketoacidosis: a retrospective analysis of the eICU database.
العنوان: | Association between blood urea nitrogen to serum albumin ratio and in-hospital mortality in critical patients with diabetic ketoacidosis: a retrospective analysis of the eICU database. |
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المؤلفون: | Chen H; Center of Cardiovascular Medicine, Inner Mongolia People's Hospital, Hohhot, China.; Graduate School, Inner Mongolia Medical University, Hohhot, China., Wang Y; Center of Cardiovascular Medicine, Inner Mongolia People's Hospital, Hohhot, China.; Graduate School, Inner Mongolia Medical University, Hohhot, China., Ji R; Center of Cardiovascular Medicine, Inner Mongolia People's Hospital, Hohhot, China.; Graduate School, Inner Mongolia Medical University, Hohhot, China., Li M; Center of Cardiovascular Medicine, Inner Mongolia People's Hospital, Hohhot, China.; State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China. |
المصدر: | Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2024 Jun 27; Vol. 15, pp. 1411891. Date of Electronic Publication: 2024 Jun 27 (Print Publication: 2024). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
مواضيع طبية MeSH: | Diabetic Ketoacidosis*/mortality , Diabetic Ketoacidosis*/blood , Hospital Mortality* , Blood Urea Nitrogen*, Humans ; Male ; Female ; Retrospective Studies ; Middle Aged ; Adult ; Serum Albumin/analysis ; Serum Albumin/metabolism ; Databases, Factual ; Aged ; Critical Illness/mortality |
مستخلص: | Background: This study aimed to investigate the association between blood urea nitrogen to serum albumin ratio (BAR) and the risk of in-hospital mortality in patients with diabetic ketoacidosis. Methods: A total of 3,962 diabetic ketoacidosis patients from the eICU Collaborative Research Database were included in this analysis. The primary outcome was in-hospital death. Results: Over a median length of hospital stay of 3.1 days, 86 in-hospital deaths were identified. One unit increase in LnBAR was positively associated with the risk of in-hospital death (hazard ratio [HR], 1.82 [95% CI, 1.42-2.34]). Furthermore, a nonlinear, consistently increasing correlation between elevated BAR and in-hospital mortality was observed (P for trend =0.005 after multiple-adjusted). When BAR was categorized into quartiles, the higher risk of in-hospital death (multiple-adjusted HR, 1.99 [95% CI, (1.1-3.6)]) was found in participants in quartiles 3 to 4 (BAR≥6.28) compared with those in quartiles 1 to 2 (BAR<6.28). In the subgroup analysis, the LnBAR-hospital death association was significantly stronger in participants without kidney insufficiency (yes versus no, P-interaction=0.023). Conclusion: There was a significant and positive association between BAR and the risk of in-hospital death in patients with diabetic ketoacidosis. Notably, the strength of this association was intensified among those without kidney insufficiency. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Chen, Wang, Ji and Li.) |
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فهرسة مساهمة: | Keywords: blood urea nitrogen to serum albumin ratio; diabetic ketoacidosis; eICU database; in-hospital mortality; intensive care unit |
المشرفين على المادة: | 0 (Serum Albumin) |
تواريخ الأحداث: | Date Created: 20240712 Date Completed: 20240712 Latest Revision: 20240714 |
رمز التحديث: | 20240714 |
مُعرف محوري في PubMed: | PMC11236567 |
DOI: | 10.3389/fendo.2024.1411891 |
PMID: | 38994011 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1664-2392 |
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DOI: | 10.3389/fendo.2024.1411891 |