دورية أكاديمية
Hyperpolarized 13 C and 31 P MRS detects differences in cardiac energetics, metabolism, and function in obesity, and responses following treatment.
| العنوان: | Hyperpolarized 13 C and 31 P MRS detects differences in cardiac energetics, metabolism, and function in obesity, and responses following treatment. |
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| المؤلفون: | Lewis AJM; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Dodd MS; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Centre for Health and Life Sciences, Coventry University, Coventry, UK., Sourdon J; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Lygate CA; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Clarke K; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Neubauer S; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Tyler DJ; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Rider OJ; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK. |
| المصدر: | NMR in biomedicine [NMR Biomed] 2024 Jul 12, pp. e5206. Date of Electronic Publication: 2024 Jul 12. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Country of Publication: England NLM ID: 8915233 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-1492 (Electronic) Linking ISSN: 09523480 NLM ISO Abbreviation: NMR Biomed Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Chichester : Wiley Original Publication: London : Heyden & Son, 1988- |
| مستخلص: | Obesity is associated with important changes in cardiac energetics and function, and an increased risk of adverse cardiovascular outcomes. Multi-nuclear MRS and MRI techniques have the potential to provide a comprehensive non-invasive assessment of cardiac metabolic perturbation in obesity. A rat model of obesity was created by high-fat diet feeding. This model was characterized using in vivo hyperpolarized [1- 13 C]pyruvate and [2- 13 C]pyruvate MRS, echocardiography and perfused heart 31 P MRS. Two groups of obese rats were subsequently treated with either caloric restriction or the glucagon-like peptide-1 analogue/agonist liraglutide, prior to reassessment. The model recapitulated cardiovascular consequences of human obesity, including mild left ventricular hypertrophy, and diastolic, but not systolic, dysfunction. Hyperpolarized 13 C and 31 P MRS demonstrated that obesity was associated with reduced myocardial pyruvate dehydrogenase flux, altered cardiac tricarboxylic acid (TCA) cycle metabolism, and impaired myocardial energetic status (lower phosphocreatine to adenosine triphosphate ratio and impaired cardiac ΔG (© 2024 The Author(s). NMR in Biomedicine published by John Wiley & Sons Ltd.) |
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| معلومات مُعتمدة: | FS/19/18/34252 Academy of Medical Sciences and the British Heart Foundation; FS/14/17/30634 Academy of Medical Sciences and the British Heart Foundation; RG/13/8/30266 Academy of Medical Sciences and the British Heart Foundation; RG/18/12/34040 Academy of Medical Sciences and the British Heart Foundation; RE/18/3/34214 BHF Oxford Centre for Research Excellence |
| فهرسة مساهمة: | Keywords: diastolic function; hyperpolarized MRI; obesity |
| تواريخ الأحداث: | Date Created: 20240712 Latest Revision: 20240712 |
| رمز التحديث: | 20240712 |
| DOI: | 10.1002/nbm.5206 |
| PMID: | 38994722 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1099-1492 |
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| DOI: | 10.1002/nbm.5206 |