دورية أكاديمية
Multilocus sequence typing of pathogenic treponemes isolated from contagious ovine digital dermatitis stage five lesions: Implications for disease transmission dynamics.
| العنوان: | Multilocus sequence typing of pathogenic treponemes isolated from contagious ovine digital dermatitis stage five lesions: Implications for disease transmission dynamics. |
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| المؤلفون: | Clegg SR; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK; School of Life and Environmental Sciences, University of Lincoln, Joseph Banks Laboratories, Lincoln, UK. Electronic address: SClegg@Lincoln.ac.uk., Angell JW; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK; Wern Vets CYF, Department of Research and Innovation, Unit 11, Lon Parcwr Industrial Estate, Ruthin, Denbighshire LL15 1NJ, UK., Millson SH; School of Life and Environmental Sciences, University of Lincoln, Joseph Banks Laboratories, Lincoln, UK., Duncan JS; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK., Staton GJ; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK., Evans NJ; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK. |
| المصدر: | Research in veterinary science [Res Vet Sci] 2024 Sep; Vol. 177, pp. 105345. Date of Electronic Publication: 2024 Jul 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: British Veterinary Association Country of Publication: England NLM ID: 0401300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2661 (Electronic) Linking ISSN: 00345288 NLM ISO Abbreviation: Res Vet Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : British Veterinary Association Original Publication: Oxford. |
| مواضيع طبية MeSH: | Treponema*/genetics , Treponema*/classification , Sheep Diseases*/microbiology , Sheep Diseases*/transmission , Digital Dermatitis*/microbiology , Digital Dermatitis*/transmission , Multilocus Sequence Typing*/veterinary , Treponemal Infections*/veterinary , Treponemal Infections*/microbiology , Treponemal Infections*/transmission, Animals ; Sheep |
| مستخلص: | Contagious ovine digital dermatitis (CODD) causes a severe, infectious foot disease and lameness of sheep, is common within the UK and is now also emerging in other countries. As well as causing severe animal welfare issues, huge economic losses emerge from the disease due to weight loss/lack of weight gain, and veterinary treatments. CODD lesion progress is measured, with a scoring system from 1 (early lesions) to 5 (healed). Here, using samples from an experimental flock infected by natural means, samples were taken from CODD stage 5 lesions, post treatment, and subjected to bacterial isolation and MLST using previously published methods. Sequences were compared to others from the same flock, and those from previous studies. All CODD 5 lesions produced viable Treponema spp. bacteria. High levels of variation of bacteria were seen, with 12 sequence types (STs) for T. medium phylogroup (11 new), 15 STs for T. phagedenis phylogroup (9 new) and six T. pedis STs, of which two were new. This study shows that CODD stage 5 lesions still contain viable bacteria, representing all three known pathogenic Treponema spp. phylogroups, and these may thus play a role in disease transmission and epidemiology despite appearing healed after treatment. The high level CODD treponeme variability within an infected flock where sheep were bought from different sources, as might occur in common agricultural practice, may suggest reasons as to why the bacterial disease is difficult to treat, control and eradicate, and adds further complexity to the polybacterial pathogenesis of these lesions. Competing Interests: Declaration of competing interest None. (Copyright © 2023. Published by Elsevier Ltd.) |
| فهرسة مساهمة: | Keywords: CODD; Evolution; Lameness; MLST; Sheep; Treponema |
| تواريخ الأحداث: | Date Created: 20240712 Date Completed: 20240812 Latest Revision: 20240812 |
| رمز التحديث: | 20240813 |
| DOI: | 10.1016/j.rvsc.2024.105345 |
| PMID: | 38996658 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1532-2661 |
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| DOI: | 10.1016/j.rvsc.2024.105345 |