دورية أكاديمية
أعرض في EDS

Decrease of alpha-crystallin A by miR-325-3p in retinal cells under blue light exposure.

التفاصيل البيبلوغرافية
العنوان: Decrease of alpha-crystallin A by miR-325-3p in retinal cells under blue light exposure.
المؤلفون: Oh S; Catholic Institute for Visual Science, College of Medicine, The Catholic University of Korea, Seoul 06591, South Korea., Kim C; Catholic Institute for Visual Science, College of Medicine, The Catholic University of Korea, Seoul 06591, South Korea., Park YH; Catholic Institute for Visual Science, College of Medicine, The Catholic University of Korea, Seoul 06591, South Korea; Department of Ophthalmology, College of Medicine, The Catholic University of Korea, Seoul 06591, South Korea. Electronic address: parkyh@catholic.ac.kr.
المصدر: Molecules and cells [Mol Cells] 2024 Aug; Vol. 47 (8), pp. 100091. Date of Electronic Publication: 2024 Jul 10.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Korean Society for Molecular and Cellular Biology Country of Publication: United States NLM ID: 9610936 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0219-1032 (Electronic) Linking ISSN: 10168478 NLM ISO Abbreviation: Mol Cells Subsets: MEDLINE
أسماء مطبوعة: Publication: <2014->: Seoul : Korean Society for Molecular and Cellular Biology
Original Publication: Seoul : Korean Society for Molecular Biology,
مواضيع طبية MeSH: Blue Light*/adverse effects , MicroRNAs*/genetics , MicroRNAs*/metabolism , Retina*/metabolism , Retina*/radiation effects, Animals ; Male ; Rats ; 3' Untranslated Regions ; alpha-Crystallin A Chain/metabolism ; alpha-Crystallin A Chain/genetics ; Apoptosis/radiation effects ; Down-Regulation ; Rats, Sprague-Dawley ; Retinal Degeneration/metabolism ; Retinal Degeneration/genetics ; Retinal Degeneration/pathology ; Retinal Degeneration/etiology
مستخلص: Exposure to blue light can lead to retinal degeneration, causing adverse effects on eye health. Although the loss of retinal cells due to blue light exposure has been observed, the precise molecular mechanisms underlying this process remain poorly understood. In this study, we investigate the role of alpha-crystallin A (CRYAA) in neuro-retinal degeneration and their regulation by blue light. We observed significant apoptotic cell death in both the retina of rats and the cultured neuro-retinal cells. The expressions of Cryaa mRNA and protein were significantly downregulated in the retina exposed to blue light. We identified that miR-325-3p reduces Cryaa mRNA and protein by binding to its 3'-untranslated region. Upregulation of miR-325-3p destabilized Cryaa mRNA and suppresses CRYAA, whereas downregulation of miR-325-3p increased both expressions. Blue light-induced neuro-retinal cell death was alleviated by CRYAA overexpression. These results highlight the critical role of Cryaa mRNA and miR-325-3p molecular axis in blue light-induced retinal degeneration. Consequently, targeting CRYAA and miR-325-3p presents a potential strategy for protecting against blue light-induced retinal degeneration.
Competing Interests: Declaration of Competing Interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
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فهرسة مساهمة: Keywords: Alpha-crystallin A; High-energy visible light; MicroRNAs; Neuro-retinal cell; Retina
المشرفين على المادة: 0 (3' Untranslated Regions)
0 (alpha-Crystallin A Chain)
0 (MicroRNAs)
تواريخ الأحداث: Date Created: 20240712 Date Completed: 20240822 Latest Revision: 20240828
رمز التحديث: 20240828
مُعرف محوري في PubMed: PMC11342174
DOI: 10.1016/j.mocell.2024.100091
PMID: 38997088
قاعدة البيانات: MEDLINE
الوصف
تدمد:0219-1032
DOI:10.1016/j.mocell.2024.100091