دورية أكاديمية
أعرض في EDS

KAP1 negatively regulates RNA polymerase II elongation kinetics to activate signal-induced transcription.

التفاصيل البيبلوغرافية
العنوان: KAP1 negatively regulates RNA polymerase II elongation kinetics to activate signal-induced transcription.
المؤلفون: Hyder U; Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Challa A; Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Thornton M; Laboratory of Signaling and Gene Regulation, Cecil H. and Ida Green Center for Reproductive Biology Sciences, The University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Nandu T; Laboratory of Signaling and Gene Regulation, Cecil H. and Ida Green Center for Reproductive Biology Sciences, The University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Kraus WL; Laboratory of Signaling and Gene Regulation, Cecil H. and Ida Green Center for Reproductive Biology Sciences, The University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., D'Orso I; Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. Ivan.Dorso@utsouthwestern.edu.
المصدر: Nature communications [Nat Commun] 2024 Jul 12; Vol. 15 (1), pp. 5859. Date of Electronic Publication: 2024 Jul 12.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Tripartite Motif-Containing Protein 28*/metabolism , Tripartite Motif-Containing Protein 28*/genetics , RNA Polymerase II*/metabolism, Humans ; Kinetics ; Transcription Elongation, Genetic ; Genes, Immediate-Early ; Transcription, Genetic ; Signal Transduction ; Transcriptional Activation ; Animals
مستخلص: Signal-induced transcriptional programs regulate critical biological processes through the precise spatiotemporal activation of Immediate Early Genes (IEGs); however, the mechanisms of transcription induction remain poorly understood. By combining an acute depletion system with several genomics approaches to interrogate synchronized, temporal transcription, we reveal that KAP1/TRIM28 is a first responder that fulfills the temporal and heightened transcriptional demand of IEGs. Acute KAP1 loss triggers an increase in RNA polymerase II elongation kinetics during early stimulation time points. This elongation defect derails the normal progression through the transcriptional cycle during late stimulation time points, ultimately leading to decreased recruitment of the transcription apparatus for re-initiation thereby dampening IEGs transcriptional output. Collectively, KAP1 plays a counterintuitive role by negatively regulating transcription elongation to support full activation across multiple transcription cycles of genes critical for cell physiology and organismal functions.
(© 2024. The Author(s).)
التعليقات: Update of: bioRxiv. 2024 May 05:2024.05.05.592422. doi: 10.1101/2024.05.05.592422. (PMID: 38746145)
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معلومات مُعتمدة: R03 CA259672 United States CA NCI NIH HHS; F99CA264296 U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI); R01 AI114362 United States AI NIAID NIH HHS; P30 CA142543 United States CA NCI NIH HHS; P50 CA196516 United States CA NCI NIH HHS; P50 CA070907 United States CA NCI NIH HHS; F99 CA264296 United States CA NCI NIH HHS; R01 DK058110 United States DK NIDDK NIH HHS; R01DK058110 U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases)
المشرفين على المادة: EC 2.3.2.27 (Tripartite Motif-Containing Protein 28)
EC 2.7.7.- (RNA Polymerase II)
EC 2.3.2.27 (TRIM28 protein, human)
تواريخ الأحداث: Date Created: 20240712 Date Completed: 20240712 Latest Revision: 20240722
رمز التحديث: 20240722
مُعرف محوري في PubMed: PMC11245487
DOI: 10.1038/s41467-024-49905-7
PMID: 38997286
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-024-49905-7