دورية أكاديمية
Non-insulin-based insulin resistance indices predict early neurological deterioration in elderly and middle-aged acute ischemic stroke patients in Northeast China.
العنوان: | Non-insulin-based insulin resistance indices predict early neurological deterioration in elderly and middle-aged acute ischemic stroke patients in Northeast China. |
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المؤلفون: | Wang J; Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, No.148. Baojian Road, NanGangDistrict, Harbin City, Heilongjiang Province, China., Tang H; Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, No.148. Baojian Road, NanGangDistrict, Harbin City, Heilongjiang Province, China., Tian J; Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, No.148. Baojian Road, NanGangDistrict, Harbin City, Heilongjiang Province, China., Xie Y; Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, No.148. Baojian Road, NanGangDistrict, Harbin City, Heilongjiang Province, China., Wu Y; Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, No.148. Baojian Road, NanGangDistrict, Harbin City, Heilongjiang Province, China. wuyun7770@163.com. |
المصدر: | Scientific reports [Sci Rep] 2024 Jul 12; Vol. 14 (1), pp. 16138. Date of Electronic Publication: 2024 Jul 12. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
مواضيع طبية MeSH: | Insulin Resistance* , Ischemic Stroke*/blood , Ischemic Stroke*/diagnosis, Humans ; Male ; Female ; Aged ; China/epidemiology ; Middle Aged ; Retrospective Studies ; Risk Factors ; Prognosis ; Triglycerides/blood ; ROC Curve |
مستخلص: | Insulin resistance (IR) has a strong association with acute ischemic stroke (AIS) occurrence and poor prognosis of afflicted patients. However, the relation between early neurological deterioration (END) risk and IR in elderly and middle-aged patients remains to be thoroughly studied. Here, we investigated the relationship between four indicators of IR and the risk of END in middle-aged patients patients with AIS. The study retrospectively analyzed 1696 elderly and middle-aged patients having AIS between January 2019 and June 2023. Within 7 days of admission, the patients were then stratified relying upon alternations in the National Institutes of Health Stroke Scale. Subsequently, we employed logistic regression analyses for assessing each index correlation with END on the basis of the tertiles of TyG index (TyGI), triglyceride to high-density lipoprotein ratio (TG/HDL), TyG-BMI, alongside IR metabolic score (METS-IR). These four indicators were significantly heightened in the END group (n = 680) in comparison to the non-END group (n = 1016). When grouping using tertiles, the four aforementioned indicators emerged as independent risk factors for END occurrence, whether or not adjusted for confounding factors. The results revealed a progressive elevation in END occurrence risk with the rise in the tertile of each indicator. Finally, we utilized receiver operating characteristic (ROC) curves for assessing the indicators' predictive power. TyG-BMI, TyGI, TG/HDL, and METS-IRs' area under the curve (AUC) were, respectively, 0.736 (95% CI: 0.712-0.761; P < 0.001), 0. 694 (95% CI: 0.668-0.721; P < 0.001), 0.684 (95% CI: 0.658-0.711; P < 0.001), and 0.722 (95% CI: 0.697-0.747; P < 0.001). IR is associated with END risk in middle-aged AIS patients. TyG-BMI, TyGI, TG/HDL, and METS-IR are independent risk factors of END in elderly and middle-aged AIS patients. Simultaneously, these four IR indicators have significant predictive power for END. (© 2024. The Author(s).) |
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فهرسة مساهمة: | Keywords: Acute ischemic stroke; Triglyceride glucose-body mass index; early neurological deterioration; insulin resistance |
المشرفين على المادة: | 0 (Triglycerides) |
تواريخ الأحداث: | Date Created: 20240712 Date Completed: 20240712 Latest Revision: 20240801 |
رمز التحديث: | 20240801 |
مُعرف محوري في PubMed: | PMC11245490 |
DOI: | 10.1038/s41598-024-66881-6 |
PMID: | 38997399 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2045-2322 |
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DOI: | 10.1038/s41598-024-66881-6 |