دورية أكاديمية
أعرض في EDS

Non-insulin-based insulin resistance indices predict early neurological deterioration in elderly and middle-aged acute ischemic stroke patients in Northeast China.

التفاصيل البيبلوغرافية
العنوان: Non-insulin-based insulin resistance indices predict early neurological deterioration in elderly and middle-aged acute ischemic stroke patients in Northeast China.
المؤلفون: Wang J; Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, No.148. Baojian Road, NanGangDistrict, Harbin City, Heilongjiang Province, China., Tang H; Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, No.148. Baojian Road, NanGangDistrict, Harbin City, Heilongjiang Province, China., Tian J; Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, No.148. Baojian Road, NanGangDistrict, Harbin City, Heilongjiang Province, China., Xie Y; Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, No.148. Baojian Road, NanGangDistrict, Harbin City, Heilongjiang Province, China., Wu Y; Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, No.148. Baojian Road, NanGangDistrict, Harbin City, Heilongjiang Province, China. wuyun7770@163.com.
المصدر: Scientific reports [Sci Rep] 2024 Jul 12; Vol. 14 (1), pp. 16138. Date of Electronic Publication: 2024 Jul 12.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Insulin Resistance* , Ischemic Stroke*/blood , Ischemic Stroke*/diagnosis, Humans ; Male ; Female ; Aged ; China/epidemiology ; Middle Aged ; Retrospective Studies ; Risk Factors ; Prognosis ; Triglycerides/blood ; ROC Curve
مستخلص: Insulin resistance (IR) has a strong association with acute ischemic stroke (AIS) occurrence and poor prognosis of afflicted patients. However, the relation between early neurological deterioration (END) risk and IR in elderly and middle-aged patients remains to be thoroughly studied. Here, we investigated the relationship between four indicators of IR and the risk of END in middle-aged patients patients with AIS. The study retrospectively analyzed 1696 elderly and middle-aged patients having AIS between January 2019 and June 2023. Within 7 days of admission, the patients were then stratified relying upon alternations in the National Institutes of Health Stroke Scale. Subsequently, we employed logistic regression analyses for assessing each index correlation with END on the basis of the tertiles of TyG index (TyGI), triglyceride to high-density lipoprotein ratio (TG/HDL), TyG-BMI, alongside IR metabolic score (METS-IR). These four indicators were significantly heightened in the END group (n = 680) in comparison to the non-END group (n = 1016). When grouping using tertiles, the four aforementioned indicators emerged as independent risk factors for END occurrence, whether or not adjusted for confounding factors. The results revealed a progressive elevation in END occurrence risk with the rise in the tertile of each indicator. Finally, we utilized receiver operating characteristic (ROC) curves for assessing the indicators' predictive power. TyG-BMI, TyGI, TG/HDL, and METS-IRs' area under the curve (AUC) were, respectively, 0.736 (95% CI: 0.712-0.761; P < 0.001), 0. 694 (95% CI: 0.668-0.721; P < 0.001), 0.684 (95% CI: 0.658-0.711; P < 0.001), and 0.722 (95% CI: 0.697-0.747; P < 0.001). IR is associated with END risk in middle-aged AIS patients. TyG-BMI, TyGI, TG/HDL, and METS-IR are independent risk factors of END in elderly and middle-aged AIS patients. Simultaneously, these four IR indicators have significant predictive power for END.
(© 2024. The Author(s).)
References: Diabetes Care. 2012 Jul;35(7):1605-10. (PMID: 22511259)
J Stroke Cerebrovasc Dis. 2024 Jan;33(1):107510. (PMID: 38000109)
J Cent Nerv Syst Dis. 2023 Feb 7;15:11795735231156349. (PMID: 36779168)
Front Endocrinol (Lausanne). 2023 Oct 02;14:1266552. (PMID: 37850101)
Front Endocrinol (Lausanne). 2022 Dec 15;13:1028167. (PMID: 36589794)
Int J Stroke. 2022 Jan;17(1):18-29. (PMID: 34986727)
Nutr Metab Cardiovasc Dis. 2024 Jan;34(1):107-111. (PMID: 37949711)
Hypertens Res. 2024 Apr;47(4):877-886. (PMID: 38012411)
Front Endocrinol (Lausanne). 2023 Sep 21;14:1180910. (PMID: 37810876)
Ther Adv Neurol Disord. 2023 Jan 24;16:17562864221147743. (PMID: 36710721)
Eur J Endocrinol. 2018 May;178(5):533-544. (PMID: 29535168)
Exp Clin Endocrinol Diabetes. 2001;109 Suppl 2:S135-48. (PMID: 11460565)
J Neurol. 2019 Mar;266(3):609-615. (PMID: 30631916)
Neurol Sci. 2023 Oct;44(10):3587-3594. (PMID: 37202593)
Cardiovasc Diabetol. 2023 Sep 16;22(1):254. (PMID: 37716947)
Cardiovasc Diabetol. 2023 Nov 8;22(1):308. (PMID: 37940952)
Front Endocrinol (Lausanne). 2022 Dec 05;13:1049211. (PMID: 36545329)
Front Endocrinol (Lausanne). 2023 May 15;14:1175988. (PMID: 37255977)
Front Public Health. 2023 Feb 03;11:1028461. (PMID: 36817911)
Cardiovasc Diabetol. 2023 Jun 29;22(1):161. (PMID: 37386494)
Diabetol Metab Syndr. 2023 Sep 19;15(1):187. (PMID: 37723527)
J Clin Hypertens (Greenwich). 2019 Aug;21(8):1063-1070. (PMID: 31318156)
Best Pract Res Clin Endocrinol Metab. 2003 Sep;17(3):305-22. (PMID: 12962688)
Nutrients. 2023 Jul 14;15(14):. (PMID: 37513557)
Cerebrovasc Dis. 2016;42(5-6):378-386. (PMID: 27351585)
Diabetol Metab Syndr. 2023 Nov 14;15(1):230. (PMID: 37957738)
Cardiovasc Diabetol. 2022 Nov 17;21(1):250. (PMID: 36397084)
J Neurol Neurosurg Psychiatry. 2015 Jan;86(1):87-94. (PMID: 24970907)
Int J Stroke. 2019 Jan;14(1):23-31. (PMID: 30188259)
BMC Neurol. 2022 Jul 16;22(1):263. (PMID: 35842590)
J Pediatr. 2022 Mar;242:79-85.e1. (PMID: 34808224)
PLoS One. 2016 Mar 01;11(3):e0149731. (PMID: 26930652)
Lipids Health Dis. 2023 Sep 5;22(1):143. (PMID: 37670344)
Diabetol Metab Syndr. 2023 May 30;15(1):112. (PMID: 37248537)
Diabetes Metab Syndr Obes. 2023 May 05;16:1283-1295. (PMID: 37179787)
Nutr Metab Cardiovasc Dis. 2024 Mar;34(3):590-597. (PMID: 37996372)
Cardiovasc Diabetol. 2023 Nov 22;22(1):320. (PMID: 37993902)
Lipids Health Dis. 2023 Jan 28;22(1):16. (PMID: 36709301)
Lancet. 2014 Jan 18;383(9913):245-54. (PMID: 24449944)
Cardiovasc Diabetol. 2022 Nov 30;21(1):264. (PMID: 36451149)
Front Endocrinol (Lausanne). 2023 Jul 28;14:1201132. (PMID: 37576971)
فهرسة مساهمة: Keywords: Acute ischemic stroke; Triglyceride glucose-body mass index; early neurological deterioration; insulin resistance
المشرفين على المادة: 0 (Triglycerides)
تواريخ الأحداث: Date Created: 20240712 Date Completed: 20240712 Latest Revision: 20240801
رمز التحديث: 20240801
مُعرف محوري في PubMed: PMC11245490
DOI: 10.1038/s41598-024-66881-6
PMID: 38997399
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-024-66881-6