دورية أكاديمية
أعرض في EDS

A Comprehensive Analysis of Fel Ursi and Its Common Adulterants Based on UHPLC-QTOF-MS E and Chemometrics.

التفاصيل البيبلوغرافية
العنوان: A Comprehensive Analysis of Fel Ursi and Its Common Adulterants Based on UHPLC-QTOF-MS E and Chemometrics.
المؤلفون: Wang X; Institute for Control of Chinese Traditional Medicine and Ethnic Medicine, National Institutes for Food and Drug Control, Beijing 102629, China., Wu H; Institute for Control of Chinese Traditional Medicine and Ethnic Medicine, National Institutes for Food and Drug Control, Beijing 102629, China.; Faculty of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, China., Li M; Institute for Control of Chinese Traditional Medicine and Ethnic Medicine, National Institutes for Food and Drug Control, Beijing 102629, China., Guo X; Institute for Control of Chinese Traditional Medicine and Ethnic Medicine, National Institutes for Food and Drug Control, Beijing 102629, China., Cheng X; Institute for Control of Chinese Traditional Medicine and Ethnic Medicine, National Institutes for Food and Drug Control, Beijing 102629, China., Jing W; Institute for Control of Chinese Traditional Medicine and Ethnic Medicine, National Institutes for Food and Drug Control, Beijing 102629, China., Wei F; Institute for Control of Chinese Traditional Medicine and Ethnic Medicine, National Institutes for Food and Drug Control, Beijing 102629, China.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2024 Jul 02; Vol. 29 (13). Date of Electronic Publication: 2024 Jul 02.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Drug Contamination*, Animals ; Chromatography, High Pressure Liquid/methods ; Bile/chemistry ; Chemometrics/methods ; Rabbits ; Cattle ; China ; Swine ; Multivariate Analysis
مستخلص: Background: As one of the four most valuable animal medicines, Fel Ursi, named Xiong Dan (XD) in China, has the effect of clearing heat, calming the liver, and brightening the eyes. However, due to the special source of XD and its high price, other animals' bile is often sold as XD or mixed with XD on the market, seriously affecting its clinical efficacy and consumers' rights and interests. In order to realize identification and adulteration analysis of XD, UHPLC-QTOF-MS E and multivariate statistical analysis were used to explore the differences in XD and six other animals' bile.
Methods: XD, pig gall (Zhu Dan, ZD), cow gall (Niu Dan, ND), rabbit gallbladder (Tu Dan, TD), duck gall (Yan Dan, YD), sheep gall (Yang Dan, YND), and chicken gall (Ji Dan, JD) were analyzed by UHPLC-QTOF-MS E , and the MS data, combined with multivariate analysis methods, were used to distinguish between them. Meanwhile, the potential chemical composition markers that contribute to their differences were further explored.
Results: The results showed that XD and six other animals' bile can be distinguished from each other obviously, with 27 ions with VIP > 1.0. We preliminarily identified 10 different bile acid-like components in XD and the other animals' bile with significant differences ( p < 0.01) and VIP > 1.0, such as tauroursodeoxycholic acid, Glycohyodeoxycholic acid, and Glycodeoxycholic acid.
Conclusions: The developed method was efficient and rapid in accurately distinguishing between XD and six other animals' bile. Based on the obtained chemical composition markers, it is beneficial to strengthen quality control for bile medicines.
References: Molecules. 2022 Dec 16;27(24):. (PMID: 36558097)
Amyloid. 2021 Dec;28(4):234-242. (PMID: 34319177)
Zhongguo Zhong Yao Za Zhi. 2019 May;44(9):1842-1849. (PMID: 31342711)
Anal Bioanal Chem. 2023 Jul;415(17):3503-3513. (PMID: 37199792)
J Chromatogr A. 2011 Jan 7;1218(1):107-17. (PMID: 21111425)
Nucleic Acids Res. 2022 Jan 7;50(D1):D622-D631. (PMID: 34986597)
Chin Med. 2023 Sep 9;18(1):116. (PMID: 37689743)
Molecules. 2021 Sep 01;26(17):. (PMID: 34500742)
BMC Psychiatry. 2022 Mar 3;22(1):162. (PMID: 35241021)
Bioanalysis. 2017 Feb;9(4):359-368. (PMID: 28074669)
Tunis Med. 2021 Avril;99(4):383-389. (PMID: 35244921)
Molecules. 2023 Jul 04;28(13):. (PMID: 37446853)
Se Pu. 2021 Jul 8;39(7):730-743. (PMID: 34227371)
Stat Med. 2021 Oct 30;40(24):5152-5173. (PMID: 34160848)
Chin Med. 2023 Feb 13;18(1):15. (PMID: 36782216)
Molecules. 2015 Oct 14;20(10):18597-619. (PMID: 26473821)
Chem Pharm Bull (Tokyo). 1998 Oct;46(10):1653-5. (PMID: 9810701)
J Pharm Biomed Anal. 2019 Sep 10;174:50-56. (PMID: 31153137)
J Ethnopharmacol. 1995 Jun 23;47(1):27-31. (PMID: 7564418)
Chem Biodivers. 2023 Mar;20(3):e202201054. (PMID: 36790137)
Anal Bioanal Chem. 2016 May;408(14):3881-90. (PMID: 27055884)
J Forensic Sci. 1997 Sep;42(5):817-23. (PMID: 9304828)
Chin Med. 2022 May 30;17(1):62. (PMID: 35637516)
Zhongguo Zhong Yao Za Zhi. 2022 Aug;47(16):4284-4291. (PMID: 36046854)
J AOAC Int. 2022 Oct 26;105(6):1555-1575. (PMID: 35723595)
Food Chem. 2021 Apr 2;357:129654. (PMID: 33866239)
Guang Pu Xue Yu Guang Pu Fen Xi. 2011 Mar;31(3):673-6. (PMID: 21595216)
Food Chem. 2022 Sep 1;387:132932. (PMID: 35421655)
معلومات مُعتمدة: 2023YF C3504105 National Key R&D Program of China; 2023X10 Research on feature recognition of bile herbs such as bear gall bladder based on multi-source data fusion
فهرسة مساهمة: Keywords: Fel Ursi; OPLS-DA; PCA; UHPLC-QTOF-MSE; Xiong Dan; chemical marker; difference analysis; multivariate statistical analysis
تواريخ الأحداث: Date Created: 20240713 Date Completed: 20240713 Latest Revision: 20240715
رمز التحديث: 20240715
مُعرف محوري في PubMed: PMC11243315
DOI: 10.3390/molecules29133144
PMID: 38999096
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules29133144