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Elucidating the Phytochemical Landscape of Leaves, Stems, and Tubers of Codonopsis convolvulacea through Integrated Metabolomics.

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العنوان: Elucidating the Phytochemical Landscape of Leaves, Stems, and Tubers of Codonopsis convolvulacea through Integrated Metabolomics.
المؤلفون: Yuan F; Key Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences, Sichuan University, Chengdu 610065, China.; Key Laboratory of Tibetan Medicine Resources Conservation and Utilization of Tibet Autonomous Region, Tibet Agriculture and Animal Husbandry University, Nyingchi 860000, China., Yan S; Key Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences, Sichuan University, Chengdu 610065, China., Zhao J; Key Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences, Sichuan University, Chengdu 610065, China.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2024 Jul 04; Vol. 29 (13). Date of Electronic Publication: 2024 Jul 04.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Plant Leaves*/chemistry , Plant Leaves*/metabolism , Plant Stems*/chemistry , Plant Stems*/metabolism , Metabolomics*/methods , Phytochemicals*/analysis , Phytochemicals*/metabolism , Plant Tubers*/chemistry , Plant Tubers*/metabolism , Codonopsis*/chemistry , Codonopsis*/metabolism, Tandem Mass Spectrometry ; Chromatography, High Pressure Liquid ; Metabolome ; Terpenes/metabolism ; Terpenes/analysis ; Plants, Medicinal/metabolism ; Plants, Medicinal/chemistry
مستخلص: Codonopsis convolvulacea is a highly valued Chinese medicinal plant containing diverse bioactive compounds. While roots/tubers have been the main medicinal parts used in practice, leaves and stems may also harbor valuable phytochemicals. However, research comparing volatiles across tissues is lacking. This study performed metabolomic profiling of leaves, stems, and tubers of C. convolvulacea to elucidate tissue-specific accumulation patterns of volatile metabolites. Ultra-high performance liquid chromatography-tandem mass spectrometry identified 302 compounds, belonging to 14 classes. Multivariate analysis clearly differentiated the metabolic profiles of the three tissues. Numerous differentially accumulated metabolites (DAMs) were detected, especially terpenoids and esters. The leaves contained more terpenoids, ester, and alcohol. The stems accumulated higher levels of terpenoids, heterocyclics, and alkaloids with pharmaceutical potential. The tubers were enriched with carbohydrates like sugars and starch, befitting their storage role, but still retained reasonable amounts of valuable volatiles. The characterization of tissue-specific metabolic signatures provides a foundation for the selective utilization of C. convolvulacea parts. Key metabolites identified include niacinamide, p-cymene, tridecanal, benzeneacetic acid, benzene, and carveol. Leaves, stems, and tubers could be targeted for antioxidants, drug development, and tonics/nutraceuticals, respectively. The metabolomic insights can also guide breeding strategies to enhance the bioactive compound content in specific tissues. This study demonstrates the value of tissue-specific metabolite profiling for informing the phytochemical exploitation and genetic improvement of medicinal plants.
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معلومات مُعتمدة: SYQ2024-02 The Nyingchi City Science and Technology Plan Project; 2023YFSY0055 Sichuan Science and Technology Program
فهرسة مساهمة: Keywords: Codonopsis convolvulacea; medicinal plants; phytochemicals; terpenoids; volatiles
المشرفين على المادة: 0 (Phytochemicals)
0 (Terpenes)
تواريخ الأحداث: Date Created: 20240713 Date Completed: 20240713 Latest Revision: 20240715
رمز التحديث: 20240715
مُعرف محوري في PubMed: PMC11243170
DOI: 10.3390/molecules29133193
PMID: 38999145
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules29133193