دورية أكاديمية
أعرض في EDS

Effects of High-Dose Vitamin D Supplementation on Placental Vitamin D Metabolism and Neonatal Vitamin D Status.

التفاصيل البيبلوغرافية
العنوان: Effects of High-Dose Vitamin D Supplementation on Placental Vitamin D Metabolism and Neonatal Vitamin D Status.
المؤلفون: Vestergaard AL; Department of Obstetrics and Gynaecology, Randers Regional Hospital, 8930 Randers, Denmark.; Department of Clinical Medicine, Aarhus University, 8200 Aarhus, Denmark., Andersen MK; Department of Obstetrics and Gynaecology, Randers Regional Hospital, 8930 Randers, Denmark.; Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark., Andersen HH; Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark., Bossow KA; Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark., Bor P; Department of Clinical Medicine, Aarhus University, 8200 Aarhus, Denmark.; Department of Obstetrics and Gynaecology, Aarhus University Hospital, 8200 Aarhus, Denmark., Larsen A; Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.
المصدر: Nutrients [Nutrients] 2024 Jul 05; Vol. 16 (13). Date of Electronic Publication: 2024 Jul 05.
نوع المنشور: Journal Article; Randomized Controlled Trial
اللغة: English
بيانات الدورية: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI Publishing
مواضيع طبية MeSH: Placenta*/metabolism , Placenta*/drug effects , Vitamin D*/administration & dosage , Vitamin D*/analogs & derivatives , Vitamin D*/blood , Dietary Supplements* , Vitamin D Deficiency*/drug therapy, Humans ; Female ; Pregnancy ; Infant, Newborn ; Adult ; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase/genetics ; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase/metabolism ; Vitamin D3 24-Hydroxylase/genetics ; Vitamin D3 24-Hydroxylase/metabolism ; Vitamin D-Binding Protein/genetics ; Vitamin D-Binding Protein/metabolism ; Receptors, Calcitriol/genetics ; Receptors, Calcitriol/metabolism ; Low Density Lipoprotein Receptor-Related Protein-2/metabolism ; Low Density Lipoprotein Receptor-Related Protein-2/genetics ; Maternal Nutritional Physiological Phenomena ; Receptors, Cell Surface
مستخلص: Vitamin D (vitD) deficiency (25-hydroxy-vitamin D < 50 nmol/L) is common in pregnancy and associated with an increased risk of adverse pregnancy outcomes. High-dose vitD supplementation is suggested to improve pregnancy health, but there is limited knowledge about the effects on placental vitD transport and metabolism and the vitD status of newborns. Comparing the current standard maternal supplementation, 10 µg/day to a 90 µg vitD supplement, we investigated placental gene expression, maternal vitD transport and neonatal vitD status. Biological material was obtained from pregnant women randomized to 10 µg or 90 µg vitD supplements from week 11-16 onwards. Possible associations between maternal exposure, neonatal vitD status and placental expression of the vitD receptor ( VDR ), the transporters (Cubilin, CUBN and Megalin, LRP2 ) and the vitD-activating and -degrading enzymes ( CYP24A1 , CYP27B1 ) were investigated. Maternal vitD-binding protein (VDBP) was determined before and after supplementation. Overall, 51% of neonates in the 10 µg vitD group were vitD-deficient in contrast to 11% in the 90 µg group. High-dose vitD supplementation did not significantly affect VDBP or placental gene expression. However, the descriptive analyses indicate that maternal obesity may lead to the differential expression of CUBN , CYP24A1 and CYP27B1 and a changed VDBP response. High-dose vitD improves neonatal vitD status without affecting placental vitD regulation.
References: Am J Clin Nutr. 2008 Aug;88(2):491S-499S. (PMID: 18689389)
Nutrients. 2020 May 20;12(5):. (PMID: 32443760)
Placenta. 2011 Feb;32(2):195-6. (PMID: 21239055)
J Bone Miner Res. 2010 Jan;25(1):14-9. (PMID: 19580464)
Lancet. 2006 Jan 7;367(9504):36-43. (PMID: 16399151)
Pediatr Allergy Immunol. 2018 May;29(3):243-253. (PMID: 29444346)
Sci Rep. 2021 Oct 20;11(1):20708. (PMID: 34671075)
Nutrients. 2023 Dec 07;15(24):. (PMID: 38140291)
Elife. 2022 Mar 08;11:. (PMID: 35256050)
N Engl J Med. 2018 Aug 09;379(6):535-546. (PMID: 30089075)
J Clin Endocrinol Metab. 2014 Apr;99(4):1348-56. (PMID: 24471562)
Ann Epidemiol. 2005 Aug;15(7):475-82. (PMID: 16029839)
Acta Obstet Gynecol Scand. 2021 Mar;100(3):480-488. (PMID: 33030742)
Semin Reprod Med. 2016 Mar;34(2):e1-13. (PMID: 27228115)
Am J Obstet Gynecol. 2013 Feb;208(2):137.e1-13. (PMID: 23131462)
Am J Clin Nutr. 2016 Aug;104(2):354-61. (PMID: 27357092)
Arch Biochem Biophys. 2012 Jul 1;523(1):37-47. (PMID: 22155151)
Lancet. 2022 Feb 12;399(10325):629-655. (PMID: 35065702)
Nutrients. 2020 Mar 21;12(3):. (PMID: 32245170)
Clin Lab Med. 2018 Sep;38(3):439-453. (PMID: 30115390)
J Clin Endocrinol Metab. 2013 Jan;98(1):114-9. (PMID: 23144468)
Rev Endocr Metab Disord. 2017 Sep;18(3):307-322. (PMID: 28214921)
Nutrients. 2018 Mar 01;10(3):. (PMID: 29494538)
Am J Clin Nutr. 2000 Sep;72(3):690-3. (PMID: 10966885)
J Clin Endocrinol Metab. 2009 Jan;94(1):26-34. (PMID: 18854395)
Matern Child Nutr. 2016 Oct;12(4):647-68. (PMID: 26373311)
Placenta. 2017 Feb;50:70-77. (PMID: 28161064)
J Acad Nutr Diet. 2020 May;120(5):898-924.e4. (PMID: 31669079)
Obes Rev. 2015 Apr;16(4):341-9. (PMID: 25688659)
Am J Clin Nutr. 2017 Dec;106(6):1439-1448. (PMID: 29021285)
J Matern Fetal Neonatal Med. 2013 Jun;26(9):889-99. (PMID: 23311886)
Am J Physiol Endocrinol Metab. 2012 Oct 1;303(7):E928-35. (PMID: 22871339)
Nutrients. 2023 May 19;15(10):. (PMID: 37242263)
Nutrients. 2020 Dec 18;12(12):. (PMID: 33352934)
Br J Nutr. 2014 Oct 14;112(7):1081-7. (PMID: 25159824)
J Pharmacol Toxicol Methods. 2015 Jan-Feb;71:147-54. (PMID: 25304941)
Obstet Gynecol Surv. 2020 Jan;75(1):39-49. (PMID: 31999352)
J Steroid Biochem Mol Biol. 2017 Oct;173:273-279. (PMID: 28216083)
J Allergy Clin Immunol. 2018 Jan;141(1):269-278.e1. (PMID: 28552588)
Pediatrics. 2011 Jun;127(6):e1513-20. (PMID: 21555499)
Epidemiology. 2004 Jan;15(1):63-70. (PMID: 14712148)
Nutrients. 2010 Mar;2(3):389-407. (PMID: 22254029)
J Bone Miner Res. 2011 Oct;26(10):2341-57. (PMID: 21706518)
Eur J Obstet Gynecol Reprod Biol. 2016 Jun;201:203-8. (PMID: 27160501)
Neoreviews. 2021 Feb;22(2):e78-e87. (PMID: 33526637)
J Nutr. 2007 Nov;137(11):2437-42. (PMID: 17951482)
BMC Pregnancy Childbirth. 2023 Mar 15;23(1):177. (PMID: 36922777)
J Endocrinol. 2019 Mar 1;:. (PMID: 30909167)
معلومات مُعتمدة: na Aarhus University; NA Aase og Ejnar Danielsens Fond; NA Axel Muusfeldts Fond; NA Augustinus Foundation; NA Danish Medical Association; NA The Toyota Foundation; NA Director Emil C.Hertz and Wife Inger Hertz' Foundation; NA Dagmar Marshalls Fond; NA Frimodt-Heineke Fonden
فهرسة مساهمة: Keywords: neonates; obesity; placenta; pregnancy; vitamin D; vitamin D metabolism; vitamin D-binding protein
المشرفين على المادة: 1406-16-2 (Vitamin D)
EC 1.14.15.18 (25-Hydroxyvitamin D3 1-alpha-Hydroxylase)
EC 1.14.15.16 (Vitamin D3 24-Hydroxylase)
0 (Vitamin D-Binding Protein)
0 (Receptors, Calcitriol)
EC 1.14.15.16 (CYP24A1 protein, human)
0 (Low Density Lipoprotein Receptor-Related Protein-2)
EC 1.14.15.18 (CYP27B1 protein, human)
0 (intrinsic factor-cobalamin receptor)
0 (Receptors, Cell Surface)
تواريخ الأحداث: Date Created: 20240713 Date Completed: 20240713 Latest Revision: 20240715
رمز التحديث: 20240715
مُعرف محوري في PubMed: PMC11243372
DOI: 10.3390/nu16132145
PMID: 38999892
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6643
DOI:10.3390/nu16132145