دورية أكاديمية
Effects of High-Dose Vitamin D Supplementation on Placental Vitamin D Metabolism and Neonatal Vitamin D Status.
العنوان: | Effects of High-Dose Vitamin D Supplementation on Placental Vitamin D Metabolism and Neonatal Vitamin D Status. |
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المؤلفون: | Vestergaard AL; Department of Obstetrics and Gynaecology, Randers Regional Hospital, 8930 Randers, Denmark.; Department of Clinical Medicine, Aarhus University, 8200 Aarhus, Denmark., Andersen MK; Department of Obstetrics and Gynaecology, Randers Regional Hospital, 8930 Randers, Denmark.; Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark., Andersen HH; Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark., Bossow KA; Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark., Bor P; Department of Clinical Medicine, Aarhus University, 8200 Aarhus, Denmark.; Department of Obstetrics and Gynaecology, Aarhus University Hospital, 8200 Aarhus, Denmark., Larsen A; Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark. |
المصدر: | Nutrients [Nutrients] 2024 Jul 05; Vol. 16 (13). Date of Electronic Publication: 2024 Jul 05. |
نوع المنشور: | Journal Article; Randomized Controlled Trial |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI Publishing |
مواضيع طبية MeSH: | Placenta*/metabolism , Placenta*/drug effects , Vitamin D*/administration & dosage , Vitamin D*/analogs & derivatives , Vitamin D*/blood , Dietary Supplements* , Vitamin D Deficiency*/drug therapy, Humans ; Female ; Pregnancy ; Infant, Newborn ; Adult ; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase/genetics ; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase/metabolism ; Vitamin D3 24-Hydroxylase/genetics ; Vitamin D3 24-Hydroxylase/metabolism ; Vitamin D-Binding Protein/genetics ; Vitamin D-Binding Protein/metabolism ; Receptors, Calcitriol/genetics ; Receptors, Calcitriol/metabolism ; Low Density Lipoprotein Receptor-Related Protein-2/metabolism ; Low Density Lipoprotein Receptor-Related Protein-2/genetics ; Maternal Nutritional Physiological Phenomena ; Receptors, Cell Surface |
مستخلص: | Vitamin D (vitD) deficiency (25-hydroxy-vitamin D < 50 nmol/L) is common in pregnancy and associated with an increased risk of adverse pregnancy outcomes. High-dose vitD supplementation is suggested to improve pregnancy health, but there is limited knowledge about the effects on placental vitD transport and metabolism and the vitD status of newborns. Comparing the current standard maternal supplementation, 10 µg/day to a 90 µg vitD supplement, we investigated placental gene expression, maternal vitD transport and neonatal vitD status. Biological material was obtained from pregnant women randomized to 10 µg or 90 µg vitD supplements from week 11-16 onwards. Possible associations between maternal exposure, neonatal vitD status and placental expression of the vitD receptor ( VDR ), the transporters (Cubilin, CUBN and Megalin, LRP2 ) and the vitD-activating and -degrading enzymes ( CYP24A1 , CYP27B1 ) were investigated. Maternal vitD-binding protein (VDBP) was determined before and after supplementation. Overall, 51% of neonates in the 10 µg vitD group were vitD-deficient in contrast to 11% in the 90 µg group. High-dose vitD supplementation did not significantly affect VDBP or placental gene expression. However, the descriptive analyses indicate that maternal obesity may lead to the differential expression of CUBN , CYP24A1 and CYP27B1 and a changed VDBP response. High-dose vitD improves neonatal vitD status without affecting placental vitD regulation. |
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معلومات مُعتمدة: | na Aarhus University; NA Aase og Ejnar Danielsens Fond; NA Axel Muusfeldts Fond; NA Augustinus Foundation; NA Danish Medical Association; NA The Toyota Foundation; NA Director Emil C.Hertz and Wife Inger Hertz' Foundation; NA Dagmar Marshalls Fond; NA Frimodt-Heineke Fonden |
فهرسة مساهمة: | Keywords: neonates; obesity; placenta; pregnancy; vitamin D; vitamin D metabolism; vitamin D-binding protein |
المشرفين على المادة: | 1406-16-2 (Vitamin D) EC 1.14.15.18 (25-Hydroxyvitamin D3 1-alpha-Hydroxylase) EC 1.14.15.16 (Vitamin D3 24-Hydroxylase) 0 (Vitamin D-Binding Protein) 0 (Receptors, Calcitriol) EC 1.14.15.16 (CYP24A1 protein, human) 0 (Low Density Lipoprotein Receptor-Related Protein-2) EC 1.14.15.18 (CYP27B1 protein, human) 0 (intrinsic factor-cobalamin receptor) 0 (Receptors, Cell Surface) |
تواريخ الأحداث: | Date Created: 20240713 Date Completed: 20240713 Latest Revision: 20240715 |
رمز التحديث: | 20240715 |
مُعرف محوري في PubMed: | PMC11243372 |
DOI: | 10.3390/nu16132145 |
PMID: | 38999892 |
قاعدة البيانات: | MEDLINE |
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