دورية أكاديمية
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Antihypertensive Potential of Pistacia lentiscus var. Chia : Molecular Insights and Therapeutic Implications.

التفاصيل البيبلوغرافية
العنوان: Antihypertensive Potential of Pistacia lentiscus var. Chia : Molecular Insights and Therapeutic Implications.
المؤلفون: Efentakis P; Laboratory of Pharmacology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis, 15771 Zografou, Greece., Symeonidi L; Laboratory of Pharmacology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis, 15771 Zografou, Greece., Gianniou DD; Department of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, 15784 Athens, Greece., Mikropoulou EV; Division of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, 15771 Athens, Greece., Giardoglou P; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, 17671 Athens, Greece., Valakos D; Center of Basic Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece., Vatsellas G; Greek Genome Centre, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece., Tsota M; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, 17671 Athens, Greece., Kostomitsopoulos N; Center of Basic Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece., Smyrnioudis I; Mastiha Research Center, Seleperos Kallimasia, 82150 Chios, Greece., Trougakos IP; Department of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, 15784 Athens, Greece., Halabalaki M; Division of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, 15771 Athens, Greece., Dedoussis GV; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, 17671 Athens, Greece., Andreadou I; Laboratory of Pharmacology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis, 15771 Zografou, Greece.
المصدر: Nutrients [Nutrients] 2024 Jul 05; Vol. 16 (13). Date of Electronic Publication: 2024 Jul 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI Publishing
مواضيع طبية MeSH: Pistacia*/chemistry , Hypertension*/drug therapy , Antihypertensive Agents*/pharmacology , Blood Pressure*/drug effects, Animals ; Male ; Rats ; Kidney/drug effects ; Kidney/metabolism ; Mastic Resin ; Disease Models, Animal ; Angiotensin II ; Rats, Sprague-Dawley ; Desoxycorticosterone Acetate ; Oxidative Stress/drug effects ; Endothelium, Vascular/drug effects ; Plant Extracts/pharmacology
مستخلص: Background: Hypertension poses a significant global health burden and is associated with cardiovascular morbidity. Chios mastic gum (CMG), derived from Pistacia lentiscus var. Chia , shows potential as a phytotherapeutic agent, due to its multifaceted beneficial effects. However, its anti-hypertensive effects and vascular, circulatory, and renal-related dysfunction, have not been thoroughly investigated. Herein, we aimed to explore the antihypertensive potential of CMG, focusing on vascular and renal endothelium, in vivo. Methods: Two models of hypertension in male rats, induced by Angiotensin II and Deoxycorticosterone acetate (DOCA)-high-salt administration, were utilized. CMG was administered at 220 mg/kg daily for four weeks after hypertension onset and blood pressure was measured non-invasively. Whole blood RNA sequencing, metabolomics, real-time PCR, and Western blot analyses of kidney and aorta tissues were additionally performed. Results: CMG significantly lowered systolic, diastolic, and mean blood pressure in both models. RNA sequencing revealed that CMG modulated immunity in the Angiotensin II model and metabolism in the DOCA-HS model. CMG downregulated genes related to oxidative stress and endothelial dysfunction and upregulated endothelial markers such as Vegfa. Metabolomic analysis indicated improved endothelial homeostasis via lysophosphatidylinositol upregulation. Conclusions: CMG emerges as a potent natural antihypertensive therapy, demonstrating beneficial effects on blood pressure and renal endothelial function.
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معلومات مُعتمدة: T2ΕΔΚ-00547 EPAnEK 2014-2020
فهرسة مساهمة: Keywords: chios mastic gum; hypertension; phytotherapeutic; renal endothelium
المشرفين على المادة: 0 (Antihypertensive Agents)
0 (Mastic Resin)
11128-99-7 (Angiotensin II)
6E0A168OB8 (Desoxycorticosterone Acetate)
0 (Plant Extracts)
تواريخ الأحداث: Date Created: 20240713 Date Completed: 20240713 Latest Revision: 20240715
رمز التحديث: 20240715
مُعرف محوري في PubMed: PMC11243328
DOI: 10.3390/nu16132152
PMID: 38999899
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6643
DOI:10.3390/nu16132152