دورية أكاديمية
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Citrullus mucosospermus Extract Reduces Weight Gain in Mice Fed a High-Fat Diet.

التفاصيل البيبلوغرافية
العنوان: Citrullus mucosospermus Extract Reduces Weight Gain in Mice Fed a High-Fat Diet.
المؤلفون: Kang HM; Department of Horticultural Bioscience/Life and Industry Convergence Research Institute, College of Natural Resources and Life Science, Pusan National University, Miryang 50463, Republic of Korea., Park SY; Institute of Nano-Bio Convergence, Pusan National University, Busan 46241, Republic of Korea., Kim JE; Department of Biomaterials Science (BK21 FOUR Program)/Life and Industry Convergence Research Institute, College of Natural Resources and Life Science, Pusan National University, Miryang 50463, Republic of Korea., Lee KW; Natural Products Convergence R&D Division, Kwangdong Pharma. Co., Ltd., Seoul 08381, Republic of Korea., Hwang DY; Department of Biomaterials Science (BK21 FOUR Program)/Life and Industry Convergence Research Institute, College of Natural Resources and Life Science, Pusan National University, Miryang 50463, Republic of Korea., Choi YW; Department of Horticultural Bioscience/Life and Industry Convergence Research Institute, College of Natural Resources and Life Science, Pusan National University, Miryang 50463, Republic of Korea.
المصدر: Nutrients [Nutrients] 2024 Jul 08; Vol. 16 (13). Date of Electronic Publication: 2024 Jul 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI Publishing
مواضيع طبية MeSH: Diet, High-Fat*/adverse effects , Plant Extracts*/pharmacology , Mice, Inbred C57BL* , Weight Gain*/drug effects , 3T3-L1 Cells* , Adipogenesis*/drug effects, Animals ; Mice ; Male ; Adipocytes/drug effects ; Obesity ; Liver/drug effects ; Liver/metabolism ; Adipose Tissue/drug effects ; Adipose Tissue/metabolism
مستخلص: This study aimed to investigate the therapeutic potential of Citrullus mucosospermus extract (CME) in counteracting adipogenesis and its associated metabolic disturbances in murine models. In vitro experiments utilizing 3T3-L1 preadipocytes revealed that CME potently inhibited adipocyte differentiation, as evidenced by a dose-dependent reduction in lipid droplet formation. Remarkably, CME also attenuated glucose uptake and intracellular triglyceride accumulation in fully differentiated adipocytes, suggesting its ability to modulate metabolic pathways in mature adipose cells. Translating these findings to an in vivo setting, we evaluated the effects of CME in C57BL/6N mice fed a high-fat diet (HFD) for 10 weeks. CME administration, concomitantly with the HFD, resulted in a significant attenuation of body weight gain compared to the HFD control group. Furthermore, CME treatment led to substantial reductions in liver weight, total fat mass, and deposits of visceral and retroperitoneal adipose tissue, underscoring its targeted impact on adipose expansion. Histological analyses revealed the remarkable effects of CME on hepatic steatosis. While the HFD group exhibited severe lipid accumulation within liver lobules, CME dose-dependently mitigated this pathology, with the highest dose virtually abolishing hepatic fat deposition. An examination of adipose tissue revealed a progressive reduction in adipocyte hypertrophy upon CME treatment, culminating in a near-normalization of adipocyte morphology at the highest dose. Notably, CME exhibited potent anti-inflammatory properties, significantly attenuating the upregulation of pro-inflammatory cytokines' mRNA levels (TNF-α, IL-1β and IL-6) in the livers of HFD-fed mice. This suggests a potential mechanism through which CME may exert protective effects against inflammation associated with obesity and fatty liver disease.
References: Foods. 2021 Aug 06;10(8):. (PMID: 34441594)
J Diabetes Metab Disord. 2020 Apr 28;19(1):343-352. (PMID: 32550185)
Cancers (Basel). 2020 May 28;12(6):. (PMID: 32481537)
Nat Rev Endocrinol. 2019 Apr;15(4):207-225. (PMID: 30733616)
Foods. 2022 Jun 24;11(13):. (PMID: 35804681)
ACS Omega. 2023 Dec 30;9(2):2272-2285. (PMID: 38250402)
Mol Metab. 2021 Jul;49:101197. (PMID: 33647469)
Food Sci Biotechnol. 2023 Aug 1;33(2):375-388. (PMID: 38222918)
Foods. 2023 Mar 18;12(6):. (PMID: 36981226)
BMC Med. 2022 Aug 18;20(1):255. (PMID: 35978404)
J Agric Food Chem. 2016 Mar 16;64(10):2062-71. (PMID: 26900108)
Plant Foods Hum Nutr. 2019 Jun;74(2):200-203. (PMID: 30756297)
Nutrients. 2023 Jan 03;15(1):. (PMID: 36615905)
Life Sci. 2023 Dec 1;334:122225. (PMID: 38084675)
Biomedicines. 2022 Jun 21;10(7):. (PMID: 35884769)
Nutrition. 2022 Jun;98:111624. (PMID: 35436691)
Sci Rep. 2022 May 16;12(1):8086. (PMID: 35577831)
Int J Mol Sci. 2023 Oct 26;24(21):. (PMID: 37958599)
Int J Mol Sci. 2024 Jan 04;25(1):. (PMID: 38203810)
PeerJ. 2021 Oct 19;9:e12343. (PMID: 34722000)
Food Chem. 2020 Oct 15;327:127059. (PMID: 32447138)
Front Nutr. 2023 Oct 09;10:1221935. (PMID: 37876615)
Cancers (Basel). 2022 Mar 25;14(7):. (PMID: 35406450)
Sci Rep. 2023 Mar 27;13(1):4993. (PMID: 36973331)
Sci Rep. 2023 Nov 16;13(1):20038. (PMID: 37973959)
Heliyon. 2023 Oct 19;9(11):e20872. (PMID: 38027663)
Front Immunol. 2019 Jul 17;10:1587. (PMID: 31379820)
Medicina (Kaunas). 2023 Oct 23;59(10):. (PMID: 37893598)
J Endocrinol. 2021 Nov 24;252(1):R1-R22. (PMID: 34592714)
PLoS One. 2023 Aug 11;18(8):e0290085. (PMID: 37566595)
Mol Nutr Food Res. 2022 Apr;66(7):e2101088. (PMID: 35106921)
فهرسة مساهمة: Keywords: Citrullus mucosospermus; anti-adipogenesis; anti-obesity effects
المشرفين على المادة: 0 (Plant Extracts)
تواريخ الأحداث: Date Created: 20240713 Date Completed: 20240713 Latest Revision: 20240715
رمز التحديث: 20240715
مُعرف محوري في PubMed: PMC11243677
DOI: 10.3390/nu16132171
PMID: 38999918
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6643
DOI:10.3390/nu16132171