دورية أكاديمية
Benefits of NGS in Advanced Lung Adenocarcinoma Vary by Populations and Timing of Examination.
العنوان: | Benefits of NGS in Advanced Lung Adenocarcinoma Vary by Populations and Timing of Examination. |
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المؤلفون: | Lee PH; Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.; Doctoral Program in Translational Medicine, National Chung Hsing University, Taichung 402, Taiwan.; Rong Hsing Translational Medicine Research Center, National Chung Hsing University, Taichung 402, Taiwan.; Institute of Biomedical Sciences, National Chung Hsing University, Taichung 402, Taiwan., Ou WF; Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan., Huang YH; Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.; Institute of Biomedical Sciences, National Chung Hsing University, Taichung 402, Taiwan.; Lung Cancer Comprehensive Care and Research Center, Taichung Veterans General Hospital, Taichung 407, Taiwan., Hsu KH; Lung Cancer Comprehensive Care and Research Center, Taichung Veterans General Hospital, Taichung 407, Taiwan.; Division of Critical Care and Respiratory Therapy, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan., Tseng JS; Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.; Institute of Biomedical Sciences, National Chung Hsing University, Taichung 402, Taiwan.; Lung Cancer Comprehensive Care and Research Center, Taichung Veterans General Hospital, Taichung 407, Taiwan.; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 402, Taiwan., Chang GC; Division of Pulmonary Medicine, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan.; School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.; Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan., Yang TY; Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan.; Doctoral Program in Translational Medicine, National Chung Hsing University, Taichung 402, Taiwan.; Rong Hsing Translational Medicine Research Center, National Chung Hsing University, Taichung 402, Taiwan.; Institute of Biomedical Sciences, National Chung Hsing University, Taichung 402, Taiwan.; Department of Life Sciences, National Chung Hsing University, Taichung 402, Taiwan. |
المصدر: | International journal of molecular sciences [Int J Mol Sci] 2024 Jun 25; Vol. 25 (13). Date of Electronic Publication: 2024 Jun 25. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, [2000- |
مواضيع طبية MeSH: | High-Throughput Nucleotide Sequencing*/methods , Adenocarcinoma of Lung*/genetics , Adenocarcinoma of Lung*/pathology , Adenocarcinoma of Lung*/mortality , Lung Neoplasms*/genetics , Lung Neoplasms*/mortality , Lung Neoplasms*/pathology , Lung Neoplasms*/drug therapy , Mutation*, Humans ; Male ; Female ; Middle Aged ; Aged ; Adult ; Aged, 80 and over |
مستخلص: | Despite the widespread application of next-generation sequencing (NGS) in advanced lung adenocarcinoma, its impact on survival and the optimal timing for the examination remain uncertain. This cohort study included advanced lung adenocarcinoma patients who underwent NGS testing. We categorized patients into four groups: Group 1: treatment-naïve, upfront NGS; Group 2: Treatment-naïve, exclusionary EGFR / ALK / ROS1 ; Group 3: post-treatment, no known EGFR / ALK / ROS1 ; Group 4: known driver mutation and post-TKI treatment. A total of 424 patients were included. There were 128, 126, 90, and 80 patients in Groups 1, 2, 3, and 4, respectively. In Groups 1, 2, 3, and 4, targetable mutations were identified in 76.6%, 49.2%, 41.1%, and 33.3% of the patients, respectively ( p < 0.001). Mutation-targeted treatments were applied in 68.0%, 15.1%, 27.8%, and 22.5% of the patients, respectively ( p < 0.001). In the overall population, patients receiving mutation-targeted treatments exhibited significantly longer overall survival (OS) (aHR 0.54 [95% CI 0.37-0.79], p = 0.001). The most profound benefit was seen in the Group 1 patients (not reached vs. 40.4 months, p = 0.028). The median OS of patients with mutation-targeted treatments was also significantly longer among Group 2 patients. The median post-NGS survival of patients receiving mutation-targeted treatments was numerically longer in Group 3 and Group 4 patients. In conclusion, mutation-targeted therapy is associated with a favorable outcome. However, the opportunities of NGS-directed treatment and the survival benefits of mutation-targeted treatment were various among different populations. Competing Interests: The authors declare no conflicts of interest. |
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فهرسة مساهمة: | Keywords: adenocarcinoma; driver mutation; lung cancer; next-generation sequencing (NGS); targeted therapy |
تواريخ الأحداث: | Date Created: 20240713 Date Completed: 20240713 Latest Revision: 20240715 |
رمز التحديث: | 20240715 |
مُعرف محوري في PubMed: | PMC11241057 |
DOI: | 10.3390/ijms25136949 |
PMID: | 39000058 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1422-0067 |
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DOI: | 10.3390/ijms25136949 |