دورية أكاديمية
Novel Techniques for Mapping DNA Damage and Repair in the Brain.
| العنوان: | Novel Techniques for Mapping DNA Damage and Repair in the Brain. |
|---|---|
| المؤلفون: | Hedlich-Dwyer J; Department of Pharmacology and Toxicology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA., Allard JS; Department of Physiology & Biophysics, Howard University College of Medicine, Washington, DC 20059, USA., Mulgrave VE; Department of Physiology & Biophysics, Howard University College of Medicine, Washington, DC 20059, USA., Kisby GE; Department of Biomedical Sciences, College of Osteopathic Medicine, Western University of Health Sciences, Lebanon, OR 97355, USA., Raber J; Department of Behavioral Neuroscience, Neurology, and Radiation Medicine, Division of Neuroscience, ONPRC, Oregon Health & Science University, Portland, OR 97239, USA., Gassman NR; Department of Pharmacology and Toxicology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA. |
| المصدر: | International journal of molecular sciences [Int J Mol Sci] 2024 Jun 27; Vol. 25 (13). Date of Electronic Publication: 2024 Jun 27. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, [2000- |
| مواضيع طبية MeSH: | DNA Damage* , DNA Repair* , Brain*/metabolism, Humans ; Animals |
| مستخلص: | DNA damage in the brain is influenced by endogenous processes and metabolism along with exogenous exposures. Accumulation of DNA damage in the brain can contribute to various neurological disorders, including neurodegenerative diseases and neuropsychiatric disorders. Traditional methods for assessing DNA damage in the brain, such as immunohistochemistry and mass spectrometry, have provided valuable insights but are limited by their inability to map specific DNA adducts and regional distributions within the brain or genome. Recent advancements in DNA damage detection methods offer new opportunities to address these limitations and further our understanding of DNA damage and repair in the brain. Here, we review emerging techniques offering more precise and sensitive ways to detect and quantify DNA lesions in the brain or neural cells. We highlight the advancements and applications of these techniques and discuss their potential for determining the role of DNA damage in neurological disease. |
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| معلومات مُعتمدة: | 1R21ES027943-00S1 United States NH NIH HHS; 1T32AG055378-00X1 United States NH NIH HHS |
| فهرسة مساهمة: | Keywords: DNA adduct; DNA damage; DNA damage response; DNA repair; fluorescent microscopy; immunohistochemistry; mitochondria; neurodegeneration; neurological disease; spatial mapping techniques |
| تواريخ الأحداث: | Date Created: 20240713 Date Completed: 20240713 Latest Revision: 20240715 |
| رمز التحديث: | 20240715 |
| مُعرف محوري في PubMed: | PMC11241736 |
| DOI: | 10.3390/ijms25137021 |
| PMID: | 39000135 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1422-0067 |
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| DOI: | 10.3390/ijms25137021 |