دورية أكاديمية
أعرض في EDS

Long-Term Proton Pump Inhibitor-Acid Suppressive Treatment Can Cause Vitamin B 12 Deficiency in Zollinger-Ellison Syndrome (ZES) Patients.

التفاصيل البيبلوغرافية
العنوان: Long-Term Proton Pump Inhibitor-Acid Suppressive Treatment Can Cause Vitamin B 12 Deficiency in Zollinger-Ellison Syndrome (ZES) Patients.
المؤلفون: Ito T; Neuroendocrine Tumor Centra, Fukuoka Sanno Hospital, International University of Health and Welfare, 3-6-45 Momochihama, Sawara-Ku, Fukuoka 814-0001, Japan., Ramos-Alvarez I; Digestive Diseases Branch, NIDDK, NIH, Bethesda, MD 20892-1804, USA., Jensen RT; Digestive Diseases Branch, NIDDK, NIH, Bethesda, MD 20892-1804, USA.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Jul 02; Vol. 25 (13). Date of Electronic Publication: 2024 Jul 02.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Proton Pump Inhibitors*/adverse effects , Proton Pump Inhibitors*/therapeutic use , Vitamin B 12 Deficiency*/drug therapy , Zollinger-Ellison Syndrome*/drug therapy , Vitamin B 12*/blood, Humans ; Female ; Male ; Middle Aged ; Adult ; Aged ; Methylmalonic Acid/blood ; Homocysteine/blood ; Homocysteine/metabolism
مستخلص: Whether the long-term treatment of patients with proton pump inhibitors (PPIs) with different diseases [GERD, Zollinger-Ellison syndrome (ZES), etc.] can result in vitamin B 12 (VB 12 ) deficiency is controversial. In this study, in 175 patients undergoing long-term ZES treatment with anti-acid therapies, drug-induced control acid secretory rates were correlated with the presence/absence of VB 12 deficiency, determined by assessing serum VB 12 levels, measurements of VB 12 body stores (blood methylmalonic acid (MMA) and total homocysteine[tHYC]), and other features of ZES. After a mean of 10.2 yrs. of any acid treatment (5.6 yrs. with PPIs), 21% had VB 12 deficiency with significantly lower serum and body VB 12 levels ( p < 0.0001). The presence of VB 12 deficiency did not correlate with any feature of ZES but was associated with a 12-fold lower acid control rate, a 2-fold higher acid control pH (6.4 vs. 3.7), and acid control secretory rates below those required for the activation of pepsin (pH > 3.5). Over a 5-yr period, the patients with VB 12 deficiency had a higher rate of achlorhydria (73% vs. 24%) and a lower rate of normal acid secretion (0% vs. 49%). In conclusion, in ZES patients, chronic long-term PPI treatment results in marked acid hyposecretion, resulting in decreased serum VB 12 levels and decreased VB 12 -body stores, which can result in VB 12 deficiency.
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معلومات مُعتمدة: NIDDK #DK053200-26 N IH intramural funds from NIDDK
فهرسة مساهمة: Keywords: PPI; Zollinger–Ellison syndrome; acid hypersecretion; gastrinomas; methylmalonic acid; neuroendocrine tumor; total homocysteine; vitamin B12 deficiency
المشرفين على المادة: 0 (Proton Pump Inhibitors)
P6YC3EG204 (Vitamin B 12)
8LL8S712J7 (Methylmalonic Acid)
0LVT1QZ0BA (Homocysteine)
تواريخ الأحداث: Date Created: 20240713 Date Completed: 20240713 Latest Revision: 20240715
رمز التحديث: 20240715
مُعرف محوري في PubMed: PMC11242121
DOI: 10.3390/ijms25137286
PMID: 39000391
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25137286