دورية أكاديمية

Vitamin D in Type 2 Diabetes and Its Correlation With Heat Shock Protein 70, Ferric Reducing Ability of Plasma, Advanced Oxidation Protein Products and Advanced Glycation End Products.

التفاصيل البيبلوغرافية
العنوان: Vitamin D in Type 2 Diabetes and Its Correlation With Heat Shock Protein 70, Ferric Reducing Ability of Plasma, Advanced Oxidation Protein Products and Advanced Glycation End Products.
المؤلفون: Hashemi N; Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran., Karimpour Reyhan S; Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran., Qahremani R; Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran., Seifouri K; Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran., Tavakoli M; Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran., Seyedi SA; Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran., Ghaemi F; Department of Biology, Kerman Branch, Islamic Azad University, Kerman, Iran., Abbaszadeh M; Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran., Esteghamati A; Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran., Nakhjavani M; Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran., Mirmiranpour H; Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran., Rabizadeh S; Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran.
المصدر: Endocrinology, diabetes & metabolism [Endocrinol Diabetes Metab] 2024 Jul; Vol. 7 (4), pp. e508.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: John Wiley & Sons Ltd Country of Publication: England NLM ID: 101732442 Publication Model: Print Cited Medium: Internet ISSN: 2398-9238 (Electronic) Linking ISSN: 23989238 NLM ISO Abbreviation: Endocrinol Diabetes Metab Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Oxford] : John Wiley & Sons Ltd., [2018]-
مواضيع طبية MeSH: Diabetes Mellitus, Type 2*/blood , Advanced Oxidation Protein Products*/blood , Glycation End Products, Advanced*/metabolism , Oxidative Stress* , Vitamin D*/blood , HSP70 Heat-Shock Proteins*/metabolism , HSP70 Heat-Shock Proteins*/blood, Humans ; Male ; Female ; Middle Aged ; Cross-Sectional Studies ; Aged ; Adult ; Biomarkers/blood ; Oxidation-Reduction
مستخلص: Aim: To investigate the association between vitamin D3 level and oxidative stress biomarkers such as Heat Shock Protein 70 (HSP70), ferric reducing ability of plasma (FRAP), advanced oxidation protein products (AOPP) and advanced glycation end products (AGEs) in patients with Type 2 diabetes.
Method: In this cross-sectional study, 54 patients including 32 females and 22 males with a mean age of 54.92 ± 11.37 years with T2D attending the diabetes clinic from 2021 to 2022 were included. According to the average level of vitamin D in this population (14.91), they were divided into two groups with vitamin D ≤15 ng/mL and vitamin D >15 ng/mL. Multivariate regression analysis was conducted to evaluate the relationship between vitamin D and AOPP, HSP and FRAP parameters. The correlation between vitamin D and other variables was evaluated via the Pearson correlation test.
Result: Vitamin D level had a positive relation with FRAP (β = 0.32, p = 0.017) and HSP (β = 0.39, p = 0.003), but had a negative relation with AOPP (β = -0.30, p = 0.02). The level of 2hPP also had a negative relation with the level of vitamin D (β = -0.33, p = 0.03). There was not any relationship between the level of vitamin D and AGEs or other variables. After adjusting for multiple confounders for the multivariate regression model, HSP remained significant.
Conclusion: This research indicates the relationship between vitamin D levels and oxidative stress biomarkers in patients with Type 2 diabetes.
(© 2024 The Author(s). Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd.)
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فهرسة مساهمة: Keywords: AOPP; FRAP; HSP70; Type 2 diabetes; inflammation; vitamin D
المشرفين على المادة: 0 (Advanced Oxidation Protein Products)
0 (Glycation End Products, Advanced)
1406-16-2 (Vitamin D)
0 (HSP70 Heat-Shock Proteins)
0 (Biomarkers)
تواريخ الأحداث: Date Created: 20240713 Date Completed: 20240713 Latest Revision: 20240809
رمز التحديث: 20240809
مُعرف محوري في PubMed: PMC11245572
DOI: 10.1002/edm2.508
PMID: 39001578
قاعدة البيانات: MEDLINE
الوصف
تدمد:2398-9238
DOI:10.1002/edm2.508