دورية أكاديمية
Interleukin(IL)-1/IL-6-inhibitor-associated drug reaction with eosinophilia and systemic symptoms (DReSS) in systemic inflammatory illnesses.
| العنوان: | Interleukin(IL)-1/IL-6-inhibitor-associated drug reaction with eosinophilia and systemic symptoms (DReSS) in systemic inflammatory illnesses. |
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| المؤلفون: | Saper VE; Dept. of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: vesaper@stanford.edu., Tian L; Dept. of Biomedical Data Science, Stanford University, Stanford, CA, USA., Verstegen RH; Hospital for Sick Children, Division of Clinical Pharmacology and Toxicology, Toronto, Canada., Conrad CK; Dept. of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA., Cidon M; Dept. of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, CA, USA., Hopper RK; Dept. of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA., Kuo CS; Dept. of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA., Osoegawa K; Histocompatibility & Immunogenetics Laboratory, Stanford Blood Center, Palo Alto, CA, USA., Baszis K; Dept. of Pediatrics, Washington University in Saint Louis School of Medicine, Saint Louis, MO, USA., Bingham CA; Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA., Ferguson I; Dept. of Pediatrics, Yale University School of Medicine, New Haven, CT, USA., Hahn T; Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA., Horne A; Dept. of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden., Isupova EA; Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia., Jones JT; Children's Mercy Hospital, Kansas City, MO, USA; University of Kansas School of Medicine, Kansas City, KS, USA., Kasapcopur Ö; Dept. of Pediatrics, Istanbul University-Cerrahpasa, Istanbul, Turkey., Klein-Gitelman MS; Dept. of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA., Kostik MM; Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia., Ozen S; Dept. of Pediatrics, Hacettepe University, Ankara, Turkey., Phadke O; University Hospitals Rainbow Babies & Children's Hospital, Cleveland, OH, USA., Prahalad S; Dept. Of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA; Children's Healthcare of Atlanta, Atlanta, GA, USA., Randell RL; Dept. of Pediatrics, Duke University School of Medicine, Durham, NC, USA., Sener S; Dept. of Pediatrics, Hacettepe University, Ankara, Turkey., Stingl C; Corewell Health, Grand Rapids, MI, USA., Abdul-Aziz R; University at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY, USA., Akoghlanian S; Dept. of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA., Al Julandani D; Bristol Royal Hospital for Children Bristol, University of Bristol, Bristol, United Kingdom., Alvarez MB; Hospital de Niños Dr Ricardo Gutierrez, Buenos Aires, Argentina., Bader-Meunier B; Hopital Universitaire Necker-Enfants Malades, Department of Paediatric Hematology-Immunology and Rheumatology, Reference Center for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Imagine Institute, Inserm U 1163, Paris, FRANCE., Balay-Dustrude EE; Seattle Children's Hospital Research Center, Seattle, WA, USA; Dept. of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA., Balboni I; Dept. of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA., Baxter SK; Seattle Children's Hospital Research Center, Seattle, WA, USA; Dept. of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA., Berard RA; Children's Hospital, London Health Sciences Centre, London, Ontario, Canada., Bhattad S; Pediatric Immunology and Rheumatology, Aster CMI Hospital, Bangalore, Karnataka, India., Bolaria R; Dept. of Pediatrics, University of British Columbia, Victoria, BC, Canada., Boneparth A; Dept. of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA., Cassidy EA; Dept. of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA., Co DO; Dept. of Pediatrics, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI, USA., Collins KP; The University of Tennessee Health Science Center, Memphis, TN, USA; LeBonheur Children's Hospital, Memphis, TN, USA., Dancey P; Janeway Children's Health and Rehabilitation Centre and Memorial University St. John's, Newfoundland and Labrador, Canada., Dickinson AM; Dept. of Pediatrics, University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA, USA., Edelheit BS; University of Connecticut School of Medicine, Farmington, CT, USA; Connecticut Children's Medical Center, Hartford, CT, USA., Espada G; Hospital de Niños Dr Ricardo Gutierrez, Buenos Aires, Argentina., Flanagan ER; Dept. Of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA; Children's Healthcare of Atlanta, Atlanta, GA, USA., Imundo LF; Dept. of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA., Jindal AK; Post Graduate Institute of Medical Education and Research, Pediatrics sector 12, Chandigarh, India., Kim HA; Dept. of Rheumatology, Ajou University School of Medicine, Suwon, Republic of South Korea., Klaus G; Philipps-University of Marburg and KfH Pediatric Kidney Center, Marburg, Germany., Lake C; Translational Genetics and Genomics Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health, Bethesda, Maryland, USA., Lapin WB; University of Connecticut School of Medicine, Farmington, CT, USA; Connecticut Children's Medical Center, Hartford, CT, USA., Lawson EF; University of California San Francisco, San Francisco, CA, USA., Marmor I; Dana-Dwek Children's Hospital Tel Aviv, Tel Aviv, Israel., Mombourquette J; Dept. of Pediatrics, Kaiser Permanente California, Roseville, CA, USA., Ogunjimi B; Centre for Health Economics Research and Modeling of Infectious Diseases (CHERMID), Vaccine and Infectious Disease Institute, University of Antwerp, Belgium., Olveda R; University of California San Francisco, San Francisco, CA, USA., Ombrello MJ; Translational Genetics and Genomics Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health, Bethesda, Maryland, USA., Onel K; Hospital for Special Surgery, New York, NY, USA; Dept. of Pediatrics, Weill Cornell Medicine, New York, NY, USA., Poholek C; Dept. of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA., Ramanan AV; University of Bristol Faculty of Health Sciences, Bristol, UK., Ravelli A; Istituto Giannina Gaslini, UO Pediatria II - Reumatologia, Istituto Giannina Gaslini, Genova, Italy; Università degli Studi di Genova, Genova, Liguria, IT., Reinhardt A; Boys Town National Research Hospital, Omaha, NE, USA., Robinson AD; Dept. of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA., Rouster-Stevens K; Dept. Of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA; Children's Healthcare of Atlanta, Atlanta, GA, USA., Saad N; University of Michigan, Michigan Medicine, Ann Arbor, MI, USA., Schneider R; Hospital for Sick Children, Toronto, Canada; Dept. of Pediatrics, University of Toronto, Toronto, Ontario, Canada., Selmanovic V; Children's Hospital University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina., Pasic IS; Children's Hospital University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina., Shenoi S; Seattle Children's Hospital Research Center, Seattle, WA, USA; Dept. of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA., Shilo NR; Dept. of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA., Soep JB; University of Colorado School of Medicine, Aurora, CO, USA., Sura A; State University of New York (SUNY) Upstate Medical University, Syracuse, NY, USA., Taber SF; Hospital for Special Surgery, New York, NY, USA; Dept. of Pediatrics, Weill Cornell Medicine, New York, NY, USA., Tesher M; University of Chicago Pritzker School of Medicine, Chicago, IL, USA., Tibaldi J; Università degli Studi di Genova, Genova, Liguria, IT., Torok KS; Dept. of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA., Tsin CM; Dept. of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA., Vasquez-Canizares N; The Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA., Villacis Nunez DS; Dept. Of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA; Children's Healthcare of Atlanta, Atlanta, GA, USA., Way EE; Inova L.J. Murphy Children's Hospital, Falls Church, VA, USA., Whitehead B; Queensland Children's Hospital, South Brisbane, QLD, Australia., Zemel LS; University of Connecticut School of Medicine, Farmington, CT, USA; Connecticut Children's Medical Center, Hartford, CT, USA., Sharma S; Dept. of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA., Fernández-Viña MA; Histocompatibility & Immunogenetics Laboratory, Stanford Blood Center, Palo Alto, CA, USA; Dept. of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Mellins ED; Dept. of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA. |
| مؤلفون مشاركون: | CARRA Registry Investigators |
| المصدر: | The journal of allergy and clinical immunology. In practice [J Allergy Clin Immunol Pract] 2024 Jul 11. Date of Electronic Publication: 2024 Jul 11. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101597220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2201 (Electronic) NLM ISO Abbreviation: J Allergy Clin Immunol Pract Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Elsevier Inc., [2013]- |
| مستخلص: | Background: After introducing interleukin(IL)-1/IL-6 inhibitors, some Still and Still-like patients developed unusual often fatal pulmonary disease. This complication was associated with scoring as DReSS (drug reaction with eosinophilia and systemic symptoms) implicating these inhibitors, although DReSS can be difficult to recognize in the setting of systemic inflammatory disease. Objective: We sought to facilitate recognition of IL-1/IL-6 inhibitor-DReSS in systemic inflammatory illnesses (Still/Still-like) by looking at timing and reaction-associated features. We evaluated outcomes of stopping or not-stopping IL-1/IL-6-inhibitors after DReSS reaction began. Methods: In an international study collaborating primarily with pediatric specialists, we characterized features of 89 drug-reaction cases versus 773 drug-exposed controls and compared outcomes of 52 cases stopping IL-1/IL-6-inhibitors to 37 cases not-stopping these drugs. Results: Before reaction began, drug-reaction cases and controls were clinically comparable, except for younger disease onset age for reaction cases with pre-existing cardiothoracic comorbidities. After reaction began, increased rates of pulmonary complications and macrophage activation syndrome (MAS), differentiated drug-reaction cases from drug-tolerant controls (p=4.7x10 -35 ; p=1.1x10 -24 , respectively). Initial DReSS feature was typically reported 2-8 weeks after initiating IL-1/IL-6-inhibition. In drug-reaction cases stopping versus not-stopping IL-1/IL-6-inhibitor treatment, reaction related features were indistinguishable, including pulmonary complication rates [75%(39/52] versus [76%(28/37)]. Those stopping subsequently required fewer medications for treatment of systemic inflammation, had decreased rates of MAS, and improved survival (p=0.005, multivariate regression). Resolution of pulmonary complications occurred in 67%(26/39) of drug-reaction cases who stopped and in none who continued inhibitors. Conclusions: In systemic inflammatory illnesses, recognition of IL-1/IL-6-inhibitor-associated reactions followed by avoidance of IL-1/IL-6-inhibitors significantly improved outcomes. (Copyright © 2024. Published by Elsevier Inc.) |
| فهرسة مساهمة: | Investigator: R Aamir; K Abulaban; A Adams; CA Lapsia; A Akinsete; S Akoghlanian; M Al Manaa; A AlBijadi; E Allenspach; A Almutairi; R Alperin; G Amarilyo; W Ambler; M Amoruso; S Angeles-Han; S Ardoin; S Armendariz; L Asfaw; NA Dagan; C Bacha; I Balboni; S Balevic; S Ballinger; S Baluta; L Barillas-Arias; M Basiaga; K Baszis; S Baxter; M Becker; A Begezda; E Behrens; E Beil; S Benseler; L Bermudez-Santiago; W Bernal; T Bigley; C Bingham; B Binstadt; C Black; B Blackmon; M Blakley; J Bohnsack; A Boneparth; H Bradfield; J Bridges; E Brooks; M Brothers; H Brunner; L Buckley; M Buckley; M Buckley; H Bukulmez; D Bullock; S Canna; L Cannon; S Canny; V Cartwright; E Cassidy; D Castro; E Chalom; J Chang; M Chang; J Chang; A Chang-Hoftman; A Chen; P Chiraseveenuprapund; K Ciaglia; D Co; E Cohen; J Collinge; H Conlon; R Connor; K Cook; A Cooper; J Cooper; K Corbin; C Correll; R Cron; M Curry; A Dalrymple; E Datyner; T Davis; D De Ranieri; J Dean; C DeCoste; F Dedeoglu; M DeGuzman; N Delnay; E DeSantis; R Devine; M Dhalla; A Dhanrajani; D Dissanayake; B Dizon; N Drapeau; J Drew; K Driest; Q Du; E Duncan; K Dunnock; D Durkee; J Dvergsten; A Eberhard; K Ede; B Edelheit; C Edens; T El Tal; M Elder; Y Elzaki; S Fadrhonc; C Failing; D Fair; L Favier; B Feldman; J Fennell; P Ferguson; I Ferguson; C Figueroa; E Flanagan; L Fogel; E Fox; M Fox; L Franklin; R Fuhlbrigge; J Fuller; M Furey; T Futch-West; S Gagne; V Gennaro; D Gerstbacher; M Gilbert; A Gironella; D Glaser; I Goh; D Goldsmith; S Gorry; N Goswami; B Gottlieb; T Graham; S Grevich; T Griffin; A Grim; A Grom; M Guevara; T Hahn; O Halyabar; MH Natur; E Hammelev; T Hammond; L Harel; J Harris; O Harry; J Hausmann; A Hay; K Hays; K Hayward; L Henderson; M Henrickson; A Hersh; K Hickey; L Hiraki; M Hiskey; P Hobday; C Hoffart; M Holland; M Hollander; S Hong; D Horton; M Horwitz; J Hsu; A Huber; A Huberts; J Huggins; L Huie; J Hui-Yuen; M Ibarra; A Imlay; L Imundo; C Inman; A Jackson; K James; G Janow; S Jared; Y Jiang; L Johnson; N Johnson; J Jones; D Kafisheh; P Kahn; K Kaidar; S Kasinathan; R Kaur; E Kessler; B Kienzle; S Kim; Y Kimura; D Kingsbury; M Kitcharoensakkul; T Klausmeier; K Klein; M Klein-Gitelman; A Knight; L Kovalick; S Kramer; C Kremer; O Kudas; T LaFlam; B Lang; S Lapidus; B Lapin; A Lasky; C Lawler; E Lawson; R Laxer; P Lee; P Lee; T Lee; A Lee; E Leisinger; L Lentini; M Lerman; Y Levinsky; D Levy; S Li; S Lieberman; L Lim; E Limenis; C Lin; N Ling; G Lionetti; R Livny; M Lloyd; M Lo; A Long; M Lopez-Peña; D Lovell; N Luca; S Lvovich; A Lytch; M Ma; A Machado; J MacMahon; J Madison; M Mannion; C Manos; L Mansfield; B Marston; T Mason; D Matchett; L McAllister; K McBrearty; J McColl; D McCurdy; K McDaniels; J McDonald; E Meidan; E Mellins; Z Mian; P Miettunen; M Miller; D Milojevic; R Mitacek; R Modica; S Mohan; T Moore; K Moore; L Moorthy; J Moreno; E Morgan; A Moyer; B Murante; A Murphy; E Muscal; O Mwizerwa; A Najafi; K Nanda; N Nasah; L Nassi; S Nativ; M Natter; K Nearanz; J Neely; L Newhall; A Nguyen; P Nigrovic; J Nocton; B Nolan; K Nowicki; R Oakes; E Oberle; S Ogbonnaya-Whittesley; E Ogbu; M Oliver; R Olveda; K Onel; A Orandi; J Padam; A Paller; N Pan; J Pandya; S Panupattanapong; AP Toledano; A Parsons; J Patel; P Patel; A Patrick; S Patrizi; S Paul; J Perfetto; M Perron; M Peskin; L Ponder; R Pooni; S Prahalad; B Puplava; M Quinlan-Waters; C Rabinovich; J Rafko; H Rahimi; K Rampone; S Ramsey; R Randell; L Ray; A Reed; A Reed; H Reid; D Reiff; S Richins; M Riebschleger; E Rife; M Riordan; M Riskalla; A Robinson; L Robinson; L Rodgers; M Rodriquez; D Rogers; T Ronis; A Rosado; M Rosenkranz; N Rosenwasser; H Rothermel; D Rothman; E Rothschild; E Roth-Wojcicki; K Rouster-Stevens; T Rubinstein; J Rupp; N Ruth; S Sabbagh; R Sadun; L Santiago; V Saper; A Sarkissian; L Scalzi; J Schahn; K Schikler; A Schlefman; H Schmeling; E Schmitt; R Schneider; G Schulert; K Schultz; C Schutt; C Seper; R Sheets; A Shehab; S Shenoi; M Sherman; J Shirley; M Shishov; D Siegel; N Singer; V Sivaraman; E Sloan; C Smith; J Smith; E Smitherman; J Soep; MB Son; D Sosna; C Spencer; L Spiegel; J Spitznagle; H Srinivasalu; H Stapp; K Steigerwald; A Stephens; YS Rakovchik; S Stern; B Stevens; R Stevenson; K Stewart; W Stewart; C Stingl; M Stoll; E Stringer; S Sule; J Sullivan; R Sundel; M Sutter; C Swaffar; N Swayne; R Syed; T Symington; G Syverson; A Szymanski; S Taber; R Tal; A Tambralli; A Taneja; T Tanner; S Tarvin; L Tate; A Taxter; J Taylor; M Tesher; T Thakurdeen; A Theisen; B Thomas; L Thomas; N Thomas; T Ting; C Todd; D Toib; D Toib; K Torok; H Tory; M Toth; S Tse; C Tsin; J Twachtman-Bassett; M Twilt; T Valcarcel; R Valdovinos; A Vallee; H Van Mater; S Vandenbergen; L Vannoy; C Varghese; N Vasquez; P Vega-Fernandez; J Velez; J Verbsky; R Verstegen; E von Scheven; S Vora; L Wagner-Weiner; D Wahezi; H Waite; B Walker; H Walters; M Waterfield; A Waters; P Weiser; P Weiss; J Weiss; E Wershba; V Westheuser; A White; K Widrick; C Williams; S Wong; L Woolnough; T Wright; E Wu; A Yalcindag; S Yasin; R Yeung; K Yomogida; A Zeft; Y Zhang; Y Zhao; A Zhu Keywords: Still disease; biologic therapy; drug reaction with eosinophilia and systemic symptoms; drug-induced lung disease; hemophagocytic lymphohistiocytosis; macrophage activation syndrome; pulmonary hypertension; systemic inflammatory illnesses |
| تواريخ الأحداث: | Date Created: 20240713 Latest Revision: 20240713 |
| رمز التحديث: | 20240714 |
| DOI: | 10.1016/j.jaip.2024.07.002 |
| PMID: | 39002722 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 2213-2201 |
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| DOI: | 10.1016/j.jaip.2024.07.002 |