دورية أكاديمية
[Multiple locus variable number tandem repeat analysis genotype polymorphism of Bacillus anthracis in China].
| العنوان: | [Multiple locus variable number tandem repeat analysis genotype polymorphism of Bacillus anthracis in China]. |
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| المؤلفون: | Zhang HJ; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China., Zhang EM; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China., He JR; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China., Li W; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China., Wei JC; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China. |
| المصدر: | Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi [Zhonghua Liu Xing Bing Xue Za Zhi] 2024 Jul 10; Vol. 45 (7), pp. 990-996. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Zhonghua yi xue hui; Zhongguo yi xue ke xue yuan Liu xing bing xue wei sheng wu xue yan jiu suo Country of Publication: China NLM ID: 8208604 Publication Model: Print Cited Medium: Print ISSN: 0254-6450 (Print) Linking ISSN: 02546450 NLM ISO Abbreviation: Zhonghua Liu Xing Bing Xue Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Beijing : Zhonghua yi xue hui; Zhongguo yi xue ke xue yuan Liu xing bing xue wei sheng wu xue yan jiu suo Original Publication: [Beijing] : Zhonghua yi xue hui; Zhongguo yi xue ke xue yuan Liu xing bing xue wei sheng wu xue yan jiu suo, [1981- |
| مواضيع طبية MeSH: | Bacillus anthracis*/genetics , Genotype* , Minisatellite Repeats* , Polymorphism, Genetic*, China/epidemiology ; Phylogeny ; Anthrax/microbiology ; Anthrax/epidemiology ; Multilocus Sequence Typing ; Cluster Analysis |
| مستخلص: | Objective: To analyze the multiple locus variable number tandem repeat analysis (MLVA) genotype polymorphism of Bacillus (B.) anthracis and establish a MLVA genotype database of B. anthracis in China. Methods: B. anthracis strains isolated from different sources in China since 1947 were collected. Genotype identification was carried out using the MLVA15 genotyping protocol based on 15 variable number tandem repeat loci. The genotypes were uniformly numbered and named. The distribution characteristics of the MLVA genotypes of strains were analyzed. Software Bionumerics was used to construct clustering diagrams to analyze the genetic relationships. Results: The MLVA15 clustering analysis subdivided the isolates into 4 major groups and 91 genotypes, 54 of which were unique to China. The genotypes from MLVA15-CHN1 to MLVA15-CHN6 were widely distributed throughout China and in all eras, while other genotypes were restricted to certain regions or eras. Conclusions: This study established a MLVA genotype database of B. anthracis , which provides basis for the understanding of MLVA genetic polymorphisms and the control and molecular source tracing of the anthrax outbreaks in China. |
| معلومات مُعتمدة: | 2022YFC2305304, 2023YFC2605601 National Key Research and Development Program of China |
| فهرسة مساهمة: | Local Abstract: [Publisher, Chinese] 目的： 分析中国炭疽芽胞杆菌多位点可变数目串联重复序列分析（MLVA）基因型多态性，建立中国炭疽芽胞杆菌MLVA基因型数据库。 方法： 收集1947年以来中国不同来源的炭疽芽胞杆菌分离菌株，采用MLVA15分型策略进行基因型鉴定，对基因型进行统一编号和命名，分析不同来源菌株MLVA基因型的分布特征，同时通过Bionumerics软件绘制聚类图，分析不同基因型间的遗传关系。 结果： MLVA15分型可将533株中国炭疽芽胞杆菌分为4群91个基因型，其中54个基因型为中国独有的基因型。新命名的基因型MLVA15-CHN1~MLVA15-CHN6广泛分布于中国不同地区、不同年代和宿主，其余基因型具有地区和年代特征性。 结论： 本研究建立了中国炭疽芽胞杆菌MLVA基因型数据库，掌握了MLVA基因型分布特征及其遗传多态性，为中国炭疽疫情防控及分子溯源技术提供了参考依据。. |
| تواريخ الأحداث: | Date Created: 20240715 Date Completed: 20240715 Latest Revision: 20240715 |
| رمز التحديث: | 20240715 |
| DOI: | 10.3760/cma.j.cn112338-20231212-00350 |
| PMID: | 39004972 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0254-6450 |
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| DOI: | 10.3760/cma.j.cn112338-20231212-00350 |