دورية أكاديمية
Nepali oral microbiomes reflect a gradient of lifestyles from traditional to industrialized.
| العنوان: | Nepali oral microbiomes reflect a gradient of lifestyles from traditional to industrialized. |
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| المؤلفون: | Ryu EP; Department of Biology, Pennsylvania State University, University Park, PA., Gautam Y; Genetic Heritage Group, Program in Biology, New York University Abu Dhabi, Abu Dhabi, UAE., Proctor DM; Microbial Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD., Bhandari D; Public Health Research Laboratory, Institute of Medicine, Maharajgunj, Kathmandu, Nepal.; School of Public Health, University of Adelaide, South Australia, Australia., Tandukar S; Public Health Research Laboratory, Institute of Medicine, Maharajgunj, Kathmandu, Nepal.; Organization for Public Health and Environment Management, Lalitpur, Bagmati, Nepal., Gupta M; Department of Biology, Pennsylvania State University, University Park, PA., Gautam GP; Department of Geography, Tribhuvan University, Nepalgunj, Nepal., Relman DA; Departments of Medicine, and of Microbiology & Immunology, Stanford University, Stanford, CA.; Section of Infectious Diseases, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA., Shibl AA; Genetic Heritage Group, Program in Biology, New York University Abu Dhabi, Abu Dhabi, UAE.; Center for Genomics and Systems Biology, and Public Health Research Center, New York University Abu Dhabi, Abu Dhabi, UAE., Sherchand JB; Public Health Research Laboratory, Institute of Medicine, Maharajgunj, Kathmandu, Nepal., Jha AR; Genetic Heritage Group, Program in Biology, New York University Abu Dhabi, Abu Dhabi, UAE.; Center for Genomics and Systems Biology, and Public Health Research Center, New York University Abu Dhabi, Abu Dhabi, UAE., Davenport ER; Department of Biology, Pennsylvania State University, University Park, PA.; Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA. |
| المصدر: | BioRxiv : the preprint server for biology [bioRxiv] 2024 Jul 03. Date of Electronic Publication: 2024 Jul 03. |
| نوع المنشور: | Journal Article; Preprint |
| اللغة: | English |
| بيانات الدورية: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| مستخلص: | Background: Lifestyle plays an important role in shaping the gut microbiome. However, its contributions to the oral microbiome remains less clear, due to the confounding effects of geography and methodology in investigations of populations studied to date. Furthermore, while the oral microbiome seems to differ between foraging and industrialized populations, we lack insight into whether transitions to and away from agrarian lifestyles shape the oral microbiota. Given the growing interest in so-called 'vanishing microbiomes' potentially being a risk factor for increased disease prevalence in industrialized populations, it is important that we distinguish lifestyle from geography in the study of microbiomes across populations. Results: Here, we investigate salivary microbiomes of 63 Nepali individuals representing a spectrum of lifestyles: foraging, subsistence farming (individuals that transitioned from foraging to farming within the last 50 years), agriculturalists (individuals that have transitioned to farming for at least 300 years), and industrialists (expatriates that immigrated to the United States within the last 20 years). We characterize the role of lifestyle in microbial diversity, identify microbes that differ between lifestyles, and pinpoint specific lifestyle factors that may be contributing to differences in the microbiomes across populations. Contrary to prevailing views, when geography is controlled for, oral microbiome alpha diversity does not differ significantly across lifestyles. Microbiome composition, however, follows the gradient of lifestyles from foraging through agrarianism to industrialism, supporting the notion that lifestyle indeed plays a role in the oral microbiome. Relative abundances of several individual taxa, including Streptobacillus and an unclassified Porphyromonadaceae genus, also mirror lifestyle. Finally, we identify specific lifestyle factors associated with microbiome composition across the gradient of lifestyles, including smoking and grain source. Conclusion: Our findings demonstrate that by controlling for geography, we can isolate an important role for lifestyle in determining oral microbiome composition. In doing so, we highlight the potential contributions of several lifestyle factors, underlining the importance of carefully examining the oral microbiome across lifestyles to improve our understanding of global microbiomes. Competing Interests: Declarations Competing interests The authors declare that they have no competing interests. |
| معلومات مُعتمدة: | R35 GM146980 United States GM NIGMS NIH HHS; T32 GM102057 United States GM NIGMS NIH HHS |
| فهرسة مساهمة: | Keywords: Nepali populations; Oral microbiome; lifestyle; oral microbiota; salivary microbiome |
| تواريخ الأحداث: | Date Created: 20240715 Latest Revision: 20240722 |
| رمز التحديث: | 20240722 |
| مُعرف محوري في PubMed: | PMC11244963 |
| DOI: | 10.1101/2024.07.01.601557 |
| PMID: | 39005279 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2692-8205 |
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| DOI: | 10.1101/2024.07.01.601557 |