دورية أكاديمية
Osteocalcin, miR-143, and miR-145 Expression in Long-Standing Type 1 Diabetes Mellitus and Their Correlation with HbA1c.
العنوان: | Osteocalcin, miR-143, and miR-145 Expression in Long-Standing Type 1 Diabetes Mellitus and Their Correlation with HbA1c. |
---|---|
المؤلفون: | Hasona NA; Department of Biochemistry, Faculty of Science, Beni-Suef University, Salah Salim St., Beni Suef, 62511 Egypt.; Beni Suef National University, Beni Suef, Egypt., Moneim AA; Molecular Physiology Division, Faculty of Science, Beni-Suef University, Beni Suef, Egypt., Mohammed EA; Zoology Department, Faculty of Science, Beni-Suef University, Beni Suef, Egypt., Twab NAA; Zoology Department, Faculty of Science, Beni-Suef University, Beni Suef, Egypt., Azeem AAA; Zoology Department, Faculty of Science, Beni-Suef University, Beni Suef, Egypt., Teryak GM; Zoology Department, Faculty of Science, Beni-Suef University, Beni Suef, Egypt., Ewiss SS; Zoology Department, Faculty of Science, Beni-Suef University, Beni Suef, Egypt., Khalil RG; Immunology Division, Faculty of Science, Beni-Suef University, Beni Suef, Egypt. |
المصدر: | Indian journal of clinical biochemistry : IJCB [Indian J Clin Biochem] 2024 Jul; Vol. 39 (3), pp. 421-428. Date of Electronic Publication: 2023 Mar 15. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Association of Clinical Biochemists of India Country of Publication: India NLM ID: 8708303 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0970-1915 (Print) Linking ISSN: 09701915 NLM ISO Abbreviation: Indian J Clin Biochem Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Publication: 2008- : New Delhi : Springer India, : Association of Clinical Biochemists of India Original Publication: [Patna] : Association of Clinical Biochemists of India, [1986- |
مستخلص: | Inadequate management and control of hyperglycemia predisposes diabetic patients to a wide range of complications. Thus, this opens new windows for exploring and scrutinizing novel candidate biomarkers. This study was designed to scrutinize the relationship between HbA1c, osteocalcin, calcium, phosphorus, and expression levels of miR-143 and miR-145 in individuals with T1DM and explore their correlations and diagnostic potential for T1DM. 120 unrelated participants were included (i.e., 90 participants with type 1 diabetes mellitus and 30 healthy controls) and were allocated into two groups. Participants with T1DM were allocated into three subgroups (i.e., below 1 year, 1-8 years, and over 8 years) based on diabetic duration. Participants with T1DM experienced noticeable HbA1c elevation. However, osteocalcin, phosphorus, and calcium profiles notably declined in participants with diabetes compared with those in healthy controls. Moreover, the expression levels of miR-143 and miR-145 decreased in participants with diabetes with a significant difference between participants with diabetes and healthy controls. Additionally, significant alterations in HbA1c, osteocalcin, phosphorus, and calcium profiles and expression levels of miR-143 and miR-145 were observed with increasing diabetic duration (T1DM > 8 years compared with those with a diabetes duration of less than 1 year). This study suggests that miR-143 and miR-145 are prospective biomarkers of diabetes mellitus, which may help predict the progression of complications. Competing Interests: Conflict of interestThe authors declare that they have no competing interests. (© The Author(s), under exclusive licence to Association of Clinical Biochemists of India 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.) |
References: | Noncoding RNA Res. 2023 Jan 06;8(2):187-191. (PMID: 36710985) Int J Gen Med. 2020 Mar 10;13:89-97. (PMID: 32210605) Clin J Am Soc Nephrol. 2015 Dec 7;10(12):2232-42. (PMID: 26597304) Front Immunol. 2020 Jul 22;11:1582. (PMID: 32793223) Diabetes Res Clin Pract. 2019 Nov;157:107843. (PMID: 31518657) Indian J Clin Biochem. 2023 Jul;38(3):331-337. (PMID: 37234185) J Diabetes Res. 2018 Sep 03;2018:8121634. (PMID: 30250851) Cancers (Basel). 2020 Mar 17;12(3):. (PMID: 32192092) J Mol Cell Biol. 2020 Feb 20;12(2):152-162. (PMID: 30941422) J Pediatr Endocrinol Metab. 2010 Jul;23(7):697-707. (PMID: 20857842) Nutrients. 2020 Aug 05;12(8):. (PMID: 32764504) Biochem Biophys Res Commun. 2020 Aug 13;529(1):119-125. (PMID: 32560812) Gene. 2020 Oct 20;758:144952. (PMID: 32683074) Front Endocrinol (Lausanne). 2013 Mar 08;4:21. (PMID: 23482417) J Diabetes Res. 2021 Feb 25;2021:6656062. (PMID: 33728350) Indian J Clin Biochem. 2019 Oct;34(4):444-450. (PMID: 31686731) World J Diabetes. 2015 Apr 15;6(3):456-80. (PMID: 25897356) Arch Physiol Biochem. 2022 Oct;128(5):1175-1180. (PMID: 32412315) Cardiovasc Endocrinol. 2017 Feb 15;6(1):8-16. (PMID: 31646113) Front Mol Neurosci. 2021 Mar 04;14:631553. (PMID: 33762908) Biomed Pharmacother. 2003 Mar;57(2):98-104. (PMID: 12842495) J Diabetes Complications. 2020 Jun;34(6):107573. (PMID: 32169332) Nutr Clin Pract. 2007 Oct;22(5):517-44. (PMID: 17906277) Genomics. 2020 Jul;112(4):2688-2694. (PMID: 32135297) Int J Endocrinol. 2013;2013:842598. (PMID: 23533407) J Osteoporos. 2015;2015:174186. (PMID: 25874154) Med Sci (Basel). 2016 Apr 01;4(2):. (PMID: 29083371) J Pediatr Endocrinol Metab. 2010 Jan-Feb;23(1-2):81-6. (PMID: 20432810) Biomark Insights. 2016 Jul 03;11:95-104. (PMID: 27398023) Diabetes Metab. 2012 Feb;38(1):76-81. (PMID: 21996253) Methods. 2001 Dec;25(4):402-8. (PMID: 11846609) Mol Med. 2015 Jul 14;21:616-25. (PMID: 26181633) PLoS One. 2013;8(2):e56488. (PMID: 23437144) Int J Mol Sci. 2019 Dec 04;20(24):. (PMID: 31817135) Biomed Res Int. 2015;2015:531740. (PMID: 26221598) J Endocrinol Invest. 2014 Jul;37(7):661-6. (PMID: 24859912) Bone. 2016 Jan;82:42-9. (PMID: 26055108) Cells. 2020 Jan 23;9(2):. (PMID: 31979244) |
فهرسة مساهمة: | Keywords: HbA1c; Osteocalcin; T1DM; miR-143; miR-145 |
تواريخ الأحداث: | Date Created: 20240715 Latest Revision: 20240716 |
رمز التحديث: | 20240716 |
مُعرف محوري في PubMed: | PMC11239619 |
DOI: | 10.1007/s12291-023-01131-6 |
PMID: | 39005871 |
قاعدة البيانات: | MEDLINE |
تدمد: | 0970-1915 |
---|---|
DOI: | 10.1007/s12291-023-01131-6 |