دورية أكاديمية
أعرض في EDS

Osteocalcin, miR-143, and miR-145 Expression in Long-Standing Type 1 Diabetes Mellitus and Their Correlation with HbA1c.

التفاصيل البيبلوغرافية
العنوان: Osteocalcin, miR-143, and miR-145 Expression in Long-Standing Type 1 Diabetes Mellitus and Their Correlation with HbA1c.
المؤلفون: Hasona NA; Department of Biochemistry, Faculty of Science, Beni-Suef University, Salah Salim St., Beni Suef, 62511 Egypt.; Beni Suef National University, Beni Suef, Egypt., Moneim AA; Molecular Physiology Division, Faculty of Science, Beni-Suef University, Beni Suef, Egypt., Mohammed EA; Zoology Department, Faculty of Science, Beni-Suef University, Beni Suef, Egypt., Twab NAA; Zoology Department, Faculty of Science, Beni-Suef University, Beni Suef, Egypt., Azeem AAA; Zoology Department, Faculty of Science, Beni-Suef University, Beni Suef, Egypt., Teryak GM; Zoology Department, Faculty of Science, Beni-Suef University, Beni Suef, Egypt., Ewiss SS; Zoology Department, Faculty of Science, Beni-Suef University, Beni Suef, Egypt., Khalil RG; Immunology Division, Faculty of Science, Beni-Suef University, Beni Suef, Egypt.
المصدر: Indian journal of clinical biochemistry : IJCB [Indian J Clin Biochem] 2024 Jul; Vol. 39 (3), pp. 421-428. Date of Electronic Publication: 2023 Mar 15.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Association of Clinical Biochemists of India Country of Publication: India NLM ID: 8708303 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0970-1915 (Print) Linking ISSN: 09701915 NLM ISO Abbreviation: Indian J Clin Biochem Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2008- : New Delhi : Springer India, : Association of Clinical Biochemists of India
Original Publication: [Patna] : Association of Clinical Biochemists of India, [1986-
مستخلص: Inadequate management and control of hyperglycemia predisposes diabetic patients to a wide range of complications. Thus, this opens new windows for exploring and scrutinizing novel candidate biomarkers. This study was designed to scrutinize the relationship between HbA1c, osteocalcin, calcium, phosphorus, and expression levels of miR-143 and miR-145 in individuals with T1DM and explore their correlations and diagnostic potential for T1DM. 120 unrelated participants were included (i.e., 90 participants with type 1 diabetes mellitus and 30 healthy controls) and were allocated into two groups. Participants with T1DM were allocated into three subgroups (i.e., below 1 year, 1-8 years, and over 8 years) based on diabetic duration. Participants with T1DM experienced noticeable HbA1c elevation. However, osteocalcin, phosphorus, and calcium profiles notably declined in participants with diabetes compared with those in healthy controls. Moreover, the expression levels of miR-143 and miR-145 decreased in participants with diabetes with a significant difference between participants with diabetes and healthy controls. Additionally, significant alterations in HbA1c, osteocalcin, phosphorus, and calcium profiles and expression levels of miR-143 and miR-145 were observed with increasing diabetic duration (T1DM > 8 years compared with those with a diabetes duration of less than 1 year). This study suggests that miR-143 and miR-145 are prospective biomarkers of diabetes mellitus, which may help predict the progression of complications.
Competing Interests: Conflict of interestThe authors declare that they have no competing interests.
(© The Author(s), under exclusive licence to Association of Clinical Biochemists of India 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)
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فهرسة مساهمة: Keywords: HbA1c; Osteocalcin; T1DM; miR-143; miR-145
تواريخ الأحداث: Date Created: 20240715 Latest Revision: 20240716
رمز التحديث: 20240716
مُعرف محوري في PubMed: PMC11239619
DOI: 10.1007/s12291-023-01131-6
PMID: 39005871
قاعدة البيانات: MEDLINE
الوصف
تدمد:0970-1915
DOI:10.1007/s12291-023-01131-6