دورية أكاديمية
Maternal vitamin A and D status in second and third trimester of pregnancy and bone mineral content in offspring at nine years of age.
| العنوان: | Maternal vitamin A and D status in second and third trimester of pregnancy and bone mineral content in offspring at nine years of age. |
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| المؤلفون: | Stunes AK; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Center for Oral Health Services and Research, Mid-Norway (TkMidt), Trondheim, Norway., Mosti MP; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Department of Research and Development, Clinic of Substance Use and Addiction Medicine, St. Olavs University Hospital, Trondheim, Norway., Gustafsson MK; Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, Norway., Børsting T; Center for Oral Health Services and Research, Mid-Norway (TkMidt), Trondheim, Norway.; Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, Norway., Thorsby PM; Hormone Laboratory, Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Stafne SN; Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Clinic of Rehabilitation, St. Olavs University Hospital, Trondheim, Norway., Syversen U; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Department of Endocrinology, Clinic of Medicine, St. Olavs University Hospital, Trondheim, Norway. |
| المصدر: | Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2024 Jun 28; Vol. 15, pp. 1417656. Date of Electronic Publication: 2024 Jun 28 (Print Publication: 2024). |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
| مواضيع طبية MeSH: | Bone Density* , Vitamin A*/blood , Vitamin D*/blood , Pregnancy Trimester, Third*/blood , Pregnancy Trimester, Second*/blood, Humans ; Female ; Pregnancy ; Male ; Child ; Adult ; Vitamin D Deficiency/epidemiology ; Vitamin D Deficiency/blood ; Vitamin A Deficiency/blood ; Vitamin A Deficiency/epidemiology ; Norway/epidemiology ; Maternal Nutritional Physiological Phenomena ; Prenatal Exposure Delayed Effects/blood ; Prenatal Exposure Delayed Effects/epidemiology |
| مستخلص: | Introduction: Maternal nutritional and vitamin status during pregnancy may have long-term effects on offspring health and disease. The aim of this study was to examine the associations between maternal vitamin A and D status in pregnancy and offspring bone mineral content (BMC) at nine years of age. Methods: This is a post-hoc study of a randomized control trial including 855 pregnant women from two Norwegian cities; Trondheim and Stavanger. The women were randomized into an exercise intervention or standard antenatal care. Mother and child pairs for the present study were recruited from those still living in Trondheim after 8-10 years. Serum vitamin A (retinol) and vitamin D (25(OH)D) were measured in the 2 nd and 3 rd trimesters of pregnancy, and active vitamin D (1,25(OH) Results: A total of 119 mother and child pairs were included in the analyses. Vitamin A insufficiency (retinol < 1.05 µmol/L) and vitamin D deficiency (25(OH)D < 50 mmol/L) increased from ~7% to ~43% and from ~28% to ~33%, respectively, from the 2 nd to the 3 rd trimester. An increase in serum 1,25(OH) Conclusion: We observed a high prevalence of vitamin A insufficiency and vitamin D deficiency during pregnancy. A negative association between mid-pregnancy vitamin A status and spine BMC was observed in boys, but not girls, while no associations were found between maternal vitamin D status and child BMC. The implications of optimal vitamin A and D status in pregnancy for offspring bone health, remains a subject for further investigations. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Stunes, Mosti, Gustafsson, Børsting, Thorsby, Stafne and Syversen.) |
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| فهرسة مساهمة: | Keywords: 1,25(OH)2D; 25(OH)D; offspring bone mass; pregnancy; retinol; vitamin A; vitamin D |
| المشرفين على المادة: | 11103-57-4 (Vitamin A) 1406-16-2 (Vitamin D) |
| تواريخ الأحداث: | Date Created: 20240715 Date Completed: 20240715 Latest Revision: 20240716 |
| رمز التحديث: | 20240716 |
| مُعرف محوري في PubMed: | PMC11239386 |
| DOI: | 10.3389/fendo.2024.1417656 |
| PMID: | 39006361 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1664-2392 |
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| DOI: | 10.3389/fendo.2024.1417656 |