دورية أكاديمية
Digested casein phosphopeptides impact intestinal calcium transport in vitro .
| العنوان: | Digested casein phosphopeptides impact intestinal calcium transport in vitro . |
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| المؤلفون: | Tenenbaum M; UMR Transfronalière BioEcoAgro-INRae 1158, Univ. Lille, INRAE, Univ. Liège, UPJV, JUNIA, Univ. Artois, Univ. Littoral Côte d'Opale, F-59000 Lille, France. benoit.cudennec@univ-lille.fr., Deracinois B; UMR Transfronalière BioEcoAgro-INRae 1158, Univ. Lille, INRAE, Univ. Liège, UPJV, JUNIA, Univ. Artois, Univ. Littoral Côte d'Opale, F-59000 Lille, France. benoit.cudennec@univ-lille.fr., Dugardin C; UMR Transfronalière BioEcoAgro-INRae 1158, Univ. Lille, INRAE, Univ. Liège, UPJV, JUNIA, Univ. Artois, Univ. Littoral Côte d'Opale, F-59000 Lille, France. benoit.cudennec@univ-lille.fr., Auger J; Ingredia S.A., 51 Av. Lobbedez - CS 60946, 62033 Arras Cedex, France., Baniel A; Ingredia S.A., 51 Av. Lobbedez - CS 60946, 62033 Arras Cedex, France., Boulier A; Ingredia S.A., 51 Av. Lobbedez - CS 60946, 62033 Arras Cedex, France., Flahaut C; UMR Transfronalière BioEcoAgro-INRae 1158, Univ. Lille, INRAE, Univ. Liège, UPJV, JUNIA, Univ. Artois, Univ. Littoral Côte d'Opale, F-59000 Lille, France. benoit.cudennec@univ-lille.fr., Ravallec R; UMR Transfronalière BioEcoAgro-INRae 1158, Univ. Lille, INRAE, Univ. Liège, UPJV, JUNIA, Univ. Artois, Univ. Littoral Côte d'Opale, F-59000 Lille, France. benoit.cudennec@univ-lille.fr., Cudennec B; UMR Transfronalière BioEcoAgro-INRae 1158, Univ. Lille, INRAE, Univ. Liège, UPJV, JUNIA, Univ. Artois, Univ. Littoral Côte d'Opale, F-59000 Lille, France. benoit.cudennec@univ-lille.fr. |
| المصدر: | Food & function [Food Funct] 2024 Jul 29; Vol. 15 (15), pp. 8104-8115. Date of Electronic Publication: 2024 Jul 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101549033 Publication Model: Electronic Cited Medium: Internet ISSN: 2042-650X (Electronic) Linking ISSN: 20426496 NLM ISO Abbreviation: Food Funct Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge : Royal Society of Chemistry |
| مواضيع طبية MeSH: | Caseins*/pharmacology , Caseins*/metabolism , Caseins*/chemistry , Phosphopeptides*/pharmacology , Phosphopeptides*/metabolism , Phosphopeptides*/chemistry , Calcium*/metabolism , Intestinal Mucosa*/metabolism , Intestinal Mucosa*/drug effects, Humans ; Caco-2 Cells ; Biological Transport ; Animals ; Digestion ; Intestinal Absorption/drug effects |
| مستخلص: | Calcium is the most abundant mineral in the human body and is involved in critical physiological and cellular processes. It is essential for the development, maintenance, and integrity of bone tissue throughout life. Identifying new natural food-grade chelating agents to improve calcium uptake is of increasing interest. Casein phosphopeptides (CPPs), highly phosphorylated peptides obtained after enzymatic hydrolysis of caseins, represent promising calcium-chelating candidates. The aim of this study was to investigate, using cell culture models, the ability of a digested milk matrix enriched in CPPs to regulate calcium transport through the intestinal barrier and elucidate the involved mechanisms. To this end, a CPP-preparation underwent in vitro static digestion and was subsequently incubated with an intestinal barrier model to monitor calcium uptake and transport. Our results demonstrated that the digested CPP preparation enhanced the trans -epithelial calcium transport via paracellular pathways and that CPPs, identified by peptidomics, crossed the intestinal barrier in the same time. |
| المشرفين على المادة: | 0 (Caseins) 0 (Phosphopeptides) SY7Q814VUP (Calcium) |
| تواريخ الأحداث: | Date Created: 20240715 Date Completed: 20240729 Latest Revision: 20240729 |
| رمز التحديث: | 20240729 |
| DOI: | 10.1039/d4fo01637h |
| PMID: | 39007353 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2042-650X |
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| DOI: | 10.1039/d4fo01637h |